Ultra performance liquid chromatography – tandem mass spectrometer method applied to the analysis of both thyroid and steroid hormones in human hair

Grova, Nathalie; Wang, X.; Hardy, Emilie; Palazzi, Paul; Chata, Caroline; Appenzeller, Brice

doi:10.1016/j.chroma.2019.460648

Cited by 18 publications

(7 citation statements)

References 35 publications

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“…The protocol of using whole hair is time-saving and gets lower sample loss and lower risk of contamination. But some studies suggested that prior sample pretreatment can open up the hair matrix, thereby improving extraction efficiency, sensitivity, accuracy, and precision to a considerable extent ( 32 , 34 , 35 ).…”

Section: Discussionmentioning

confidence: 99%

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Luo

Zhang

et al. 2022

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Luo

Zhang

et al. 2022

Journal of Lipid Research

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“…MS/MS parameters for the specific detection by MRM are detailed in Table 1 . The peaks were identified as previously described ( Grova et al, 2020 ). Samples have been analyzed in a random manner and without prior identification of the different treatment groups.…”

Section: Methodsmentioning

confidence: 99%

N6-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity

et al. 2021

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DNA methylation is one of the most important epigenetic modifications and is closely related with several biological processes such as regulation of gene transcription and the development of non-malignant diseases. The prevailing dogma states that DNA methylation in eukaryotes occurs essentially through 5-methylcytosine (5mC) but recently adenine methylation was also found to be present in eukaryotes. In mouse embryonic stem cells, 6-methyladenine (6mA) was associated with the repression and silencing of genes, particularly in the X-chromosome, known to play an important role in cell fate determination. Here, we have demonstrated that 6mA is a ubiquitous eukaryotic epigenetic modification that is put in place during epigenetically sensitive periods such as embryogenesis and fetal development. In somatic cells there are clear tissue specificity in 6mA levels, with the highest 6mA levels being observed in the brain. In zebrafish, during the first 120 h of embryo development, from a single pluripotent cell to an almost fully formed individual, 6mA levels steadily increase. An identical pattern was observed over embryonic days 7–21 in the mouse. Furthermore, exposure to a neurotoxic environmental pollutant during the same early life period may led to a decrease in the levels of this modification in female rats. The identification of the periods during which 6mA epigenetic marks are put in place increases our understanding of this mammalian epigenetic modification, and raises the possibility that it may be associated with developmental processes.

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“…Yet, clinical studies using LC-MS/MS struggle with a substantial number of non-detected concentrations, particularly in samples from women (probably due to insufficient detection limits), or only include male participants in the studies [26,71,[80][81][82][83]. Other, more recent LC-MS/MS methods are yet to be tested in future studies with hair samples from both men and women [72,[84][85][86].…”

Section: Implications For Study Participantsmentioning

confidence: 99%

Testosterone Analysis in Hair

Preinbergs

2022

Linköping University Medical Dissertations

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Ultra performance liquid chromatography – tandem mass spectrometer method applied to the analysis of both thyroid and steroid hormones in human hair

Cited by 18 publications

References 35 publications

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

Measurement of 7-dehydrocholesterol and cholesterol in hair can be used in the diagnosis of Smith-Lemli-Opitz syndrome

N6-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity

Testosterone Analysis in Hair

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