Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance

Leo, Edwin E. Martínez; Peñafiel, Abigail Meza; Escalante, Víctor M. Hernández; Araujo, Zulema M. Cabrera

doi:10.1016/j.nut.2021.111419

Cited by 31 publications

(30 citation statements)

References 116 publications

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“…It is not known how UPFs could determine this effect. Recents reviews ( 31 , 32 ) introduced the mechanisms through which UPFs (and their constituents) may influence oxidative stress and the inflammatory response. Both these conditions could play an important role in modulating processes of the immune system ( 33 ), that is known to be involved in MS. UPFs are generally rich in saturated fats, free sugars, and sodium, while the intake of fiber, protein, potassium, and antioxidants are low.…”

Section: Discussionmentioning

confidence: 99%

Ultra-processed foods consumption is associated with multiple sclerosis severity

et al. 2023

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BackgroundMS is a chronic inflammatory neurological and immune-mediated disease of multifactorial etiology. Ultra-processed foods (UPFs) have been generally considered unhealthy due to their poor nutritional value. Emerging evidence suggests that factors other than their nutritional content may play an additional role toward chronic inflammation.AimTo investigate the potential association of UPF consumption and MS severity in a group of MS Italian consecutive patients.MethodsDemographic (age, sex, marital status, educational level), neurological (EDSS, MSSS), and nutritional (anthropometric measures, dietary habits) information were collected. Physical activity and smoking habits were also investigated. Food items were grouped according to the NOVA classification. Patients were classified in two groups based on MS severity (“mild” and “moderate to high”).ResultsHigher UPF consumption was associated with moderate-to-high MS severity compared to lower consumption in both the unadjusted model (OR = 2.28, 95% CI: 1.04–5.01) and after adjustment for potential background (OR = 2.46, 95% CI: 1.04–5.83) and clinical confounding factors (OR = 2.97, 95% CI: 1.13–7.77).ConclusionsAlthough these results are only preliminary and hypothesis generating, it is important to explore how various aspects of the diet may relate to MS severity in order to identify the best strategy to support MS patients over the disease course.

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Section: Discussionmentioning

confidence: 99%

Ultra-processed foods consumption is associated with multiple sclerosis severity

et al. 2023

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“…This promotes leukocyte infiltration and the activation of proinflammatory mechanisms, increasing damage to surrounding cells, leading to a vicious cycle of OS inflammation. The systemic dissemination of pro-oxidants and pro-inflammatory agents through the blood favors their interaction with other tissues, conditioning a microenvironment conducive to a chronic state of oxidation and inflammation [ 46 ]. On the other hand, pregnancy promotes a scenario of increased OS [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

et al. 2022

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Ultra-processed food (UPF) consumption during gestation may lead to increased oxidative stress (OS) and could affect pregnancy outcomes. This study aims to evaluate the association of UPF consumption during pregnancy with circulating levels of OS markers. Diet was assessed (average of three assessments) in 119 pregnant women enrolled in the OBESO perinatal cohort (Mexico), obtaining quantitative data and the percentage of energy that UPFs (NOVA) contributed to the total diet. Sociodemographic, clinical (pregestational body-mass index and gestational weight gain) and lifestyle data were collected. Maternal circulating levels of OS markers (malondialdehyde (MDA), protein carbonylation (PC), and total antioxidant capacity (TAC)) were determined at the third trimester of pregnancy. Adjusted linear regression models were performed to analyze the association between UPFs and OS markers. UPFs represented 27.99% of the total energy intake. Women with a lower UPF consumption (<75 percentile°) presented a higher intake of fiber, ω-3, ω-6, and a lower ω-6/3 ratio. Linear regression models showed that UPFs were inversely associated with TAC and MDA. Fiber intake was associated with PC. UPF intake during pregnancy may result in an increase in oxidative stress. When providing nutrition care, limiting or avoiding UPFs may be an intervention strategy that could promote a better antioxidant capacity in the body.

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“…Prolonged high insulin levels can contribute to the development of insulin resistance in tissues, which is one key factor in the pathogenesis of inflammation. According to studies, consuming high GI foods frequently is positively correlated with having higher serum levels of inflammatory markers such as CRP, TNF-α, and IL-1β, IL-6 [ 18 , 19 ]. Whereas a large intake of dietary fiber has the opposite effect [ 27 ].…”

Section: Mechanism Of Action Associated With Diets and Neurological D...mentioning

confidence: 99%

“…However, a diet excessive in simple carbohydrates is proven to have a negative impact on patients’ brain vessels [ 17 ]. Recent studies reveal that an ultra-processed diet’s high intake of simple carbohydrates and saturated fats alter the redox state, the gut microbiota, and the inflammatory response [ 18 , 19 ]. The brain integrates the received information and coordinates and influences the activity of all parts of the body [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

et al. 2023

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Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress of diseases such as Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, and Multiple Sclerosis (MD), scientists are mobilized to look for new and more effective methods of interventions. A growing body of evidence suggests that inflammatory processes and an imbalance in the composition and function of the gut microbiome, which play a critical role in the pathogenesis of various neurological diseases and dietary interventions, such as the Mediterranean diet the DASH diet, or the ketogenic diet can have beneficial effects on their course. The aim of this review was to take a closer look at the role of diet and its ingredients in modulating inflammation associated with the development and/or progression of central nervous system diseases. Presented data shows that consuming a diet abundant in fruits, vegetables, nuts, herbs, spices, and legumes that are sources of anti-inflammatory elements such as omega-3 fatty acids, polyphenols, vitamins, essential minerals, and probiotics while avoiding foods that promote inflammation, create a positive brain environment and is associated with a reduced risk of neurological diseases. Personalized nutritional interventions may constitute a non-invasive and effective strategy in combating neurological disorders.

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Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance

Cited by 31 publications

References 116 publications

Ultra-processed foods consumption is associated with multiple sclerosis severity

Ultra-processed foods consumption is associated with multiple sclerosis severity

Ultra-Processed Food Consumption during Pregnancy and Its Association with Maternal Oxidative Stress Markers

The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

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