Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study

Jafari, Fatemeh; Yarmand, Sazin; Nouri, Mehran; Nejad, Elham Tavassoli; Ramezani, Atena; Sohrabi, Zahra; Rashidkhani, Bahram

doi:10.1080/01635581.2022.2125990

Cited by 15 publications

(15 citation statements)

References 63 publications

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“…In total, seven articles with 462,292 participants and 18,673 CRC cases were included in this meta-analysis. Out of seven included studies, four of them were case-control studies ( 28 , 29 , 31 , 32 ), and three were cohort studies ( 18 , 30 , 33 ). All included studies were published in English between 2018 and 2022.…”

Section: Resultsmentioning

confidence: 99%

“…All included studies were published in English between 2018 and 2022. Two of the included studies were performed in United States ( 30 , 33 ), one in Spain ( 28 ), one in Israel ( 29 ), one in France ( 18 ), one in Morocco ( 31 ), and one in Iran ( 32 ). All participants were 18 years and older.…”

Section: Resultsmentioning

confidence: 99%

“…The quality of the included studies using NOS standards is presented in Table 3 . When included studies received a NOS score of seven or higher, they would be considered of high quality ( 18 , 28 , 30 , 32 , 33 ). Besides, the remaining two articles were identified as medium-quality ( 29 , 31 ).…”

Section: Resultsmentioning

confidence: 99%

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Association between ultra-processed food intake and risk of colorectal cancer: a systematic review and meta-analysis

Shu

Huang

et al. 2023

Front. Nutr.

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BackgroundAlthough some epidemiological studies have shown a positive relationship between high intake of ultra-processed food (UPF) and risk of colorectal cancer (CRC), the results remain inconsistent. Therefore, we conducted this systematic review and meta-analysis to clarify the association between UPF intake and CRC risk.MethodsPubMed/MEDLINE, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI) and Wan fang databases were used to search the relevant studies published up to February 2023. The summary relative risks (RRs) with the corresponding 95% confidence intervals (CIs) were estimated by comparing the highest category vs. the lowest category of UPF intake, using the random-effects models (DerSimonian-Laird method). Heterogeneity between studies was explored using the Cochran’s Q test and I-square (I2). Publication bias was assessed by examining the funnel plots, and quantified by Begg’s or Egger’s tests.ResultsA total of seven articles (three cohort and four case-control studies), involving 18,673 CRC cases and 462,292 participants, were included in our study. Combining nine effect sizes from seven articles, an increased risk of CRC was shown in the highest compared with the lowest category of UPF intake (RR = 1.26; 95%CI:1.14–1.38, p < 0.0001). Subgroup analyses showed a positive association between UPF intake and CRC risk in case–control studies (RR = 1.41; 95%CI: 1.22–1.63, p < 0.0001). When we conducted analyses separately by study area, there was a significant association between UPF intake and CRC risk in developed countries (RR = 1.20; 95%CI: 1.11–1.30, p < 0.0001).ConclusionOur results show that high UPF intake is significantly associated with a higher risk of CRC, in the absence, however, of a dose–response association. Further studies in particular of large prospective cohort studies are necessary to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Association between ultra-processed food intake and risk of colorectal cancer: a systematic review and meta-analysis

Shu

Huang

et al. 2023

Front. Nutr.

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“…Exploring the nutritional elements, including the intake of fast food, influence on the development of colorectal cancer is a crucial step toward formulating preventive measures and potential interventions 68 . Colorectal cancer is a serious health concern and public health initiatives should not only focus on dietary choices but should also address broader lifestyle factors that contribute to the risk of colorectal cancer 69 .…”

Section: Fast Foodmentioning

confidence: 99%

Cancer and Food-Related Risks: A Review

Ahmed,

Dash,

Ghosh

et al. 2024

Int J Tre Onc Sci

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This review presents the most current scientific evidence related with the interaction between diet and cancer risk. For the purpose of ensuring the food's microbiological and chemical safety, as well as improving its palatability, numerous food processing techniques have been utilized. Innovations and advancements in food processing are being driven by the growing demand for food that are not only nutritious but also convenient and healthy. When new processes and compounds are discovered as a result of improvements in analytical capabilities, it is necessary to conduct a thorough analysis of the potential effects on human health. In this review, the most recent scientific findings concerning the influence of the foods we eat and the risk of developing cancer are presented. Therefore, there is a pressing need for ongoing research as well as the development of comprehensive strategies to address these preventable causes of cancer and to encourage healthier lifestyle choices. This review presents an analysis of the most recent scientific data concerning the correlation between dietary habits and the likelihood of developing cancer. In addition to an increase in the consumption of refined sugars and foods that are high in carbohydrates, these patterns also demonstrates a decrease in the consumption of macronutrients and micronutrients. In addition to this, this review investigates the impact of certain dietary regimens, such as the Mediterranean diets, as well as the intake of meat and dairy items, on the likelihood of developing cancer. Epidemiological studies, molecular mechanisms, and emerging perspectives in the field of personalized nutrition were also been reviewed. It is the objective of this review to present a comprehensive analysis of relevant studies, offering the latest scientific insights regarding the correlation between diet and the likelihood of cancer development.

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“…Recent data from large prospective population-based cohorts identified a significant association between high consumption of ultra-processed foods (UPF) and an increased risk of CRC [ 154 ] and PC [ 155 ]. In addition, in a case-control study, the association between UPF intake and the risk of CRC increased but remained constant after adjustment for BMI, physical activity, educational level, type of job, and income [ 156 ]. In another large cohort study, the long-term follow-up of individuals consuming highly proinflammatory diets was associated with an increased risk of developing CRC, which was compensated by fiber ingestion [ 157 ].…”

Section: Common Cellular and Molecular Mechanismsmentioning

confidence: 99%

The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?

Jardim

Souza

2023

IJERPH

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The overall burden of cancer is rapidly increasing worldwide, reflecting not only population growth and aging, but also the prevalence and spread of risk factors. Gastrointestinal (GI) cancers, including stomach, liver, esophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. While smoking and alcohol use are the risk factors most commonly associated with cancer development, a growing consensus also includes dietary habits as relevant risk factors for GI cancers. Current evidence suggests that socioeconomic development results in several lifestyle modifications, including shifts in dietary habits from local traditional diets to less-healthy Western diets. Moreover, recent data indicate that increased production and consumption of processed foods underlies the current pandemics of obesity and related metabolic disorders, which are directly or indirectly associated with the emergence of various chronic noncommunicable conditions and GI cancers. However, environmental changes are not restricted to dietary patterns, and unhealthy behavioral features should be analyzed with a holistic view of lifestyle. In this review, we discussed the epidemiological aspects, gut dysbiosis, and cellular and molecular characteristics of GI cancers and explored the impact of unhealthy behaviors, diet, and physical activity on developing GI cancers in the context of progressive societal changes.

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Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study

Cited by 15 publications

References 63 publications

Association between ultra-processed food intake and risk of colorectal cancer: a systematic review and meta-analysis

Association between ultra-processed food intake and risk of colorectal cancer: a systematic review and meta-analysis

Cancer and Food-Related Risks: A Review

The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?

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