Ultra-selection of metastatic colorectal cancer patients using next generation sequencing platform to improve clinical efficacy of anti-EGFR therapy

Vidal, Joana; Dalmeses, A.; Vivas, C. Santos; García‐Carbonero, Rocío; García‐Alfonso, Pilar; Carrato, Alfredo; Elez, E.; Ortiz, Marta; Losa, Ferrán; Massutí, B.; Valladares‐Ayerbes, Manuel; Manzano, Juan Ruíz; Prado, J. Vieitez de; Gállego, José Antonio Gutiérrez; Grávalos, Cristina; Varela, Mar; Azuara, Daniel; Tabernero, Josep; Salazar, Ramón; Aranda, Evelyn; Bellosillo, B.; Montagut, Clara

doi:10.1093/annonc/mdy149.005

Annals of Oncology

2018

DOI: 10.1093/annonc/mdy149.005

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Ultra-selection of metastatic colorectal cancer patients using next generation sequencing platform to improve clinical efficacy of anti-EGFR therapy

Joana Vidal

A. Dalmeses

C. Santos Vivas

et al.

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MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway

Zhang

et al. 2020

World J Surg Onc

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Background: MiR-125 has been shown to be involved in a variety of cancers, including cervical cancer (CC). Here, our goal was to explore miR-125 functional role and molecular mechanism in cervical cancer development and progression. Methods: qRT-PCR was employ to detect miR-125 and VEGF mRNA expression. Western blot was applied for testing protein levels (VEGF, E-cadherin, N-cadherin, vimentin, AKT, p-AKT, PI3K, and p-PI3K). MTT and transwell assays were used for detecting cervical cancer cell progression, including cell viability, migration, and invasion. Results: We observed that miR-125 was downregulated, whereas VEGF was upregulated in cervical cancer tissues and cell lines (CaSki and SiHa). MiR-125 inhibited the proliferation, invasion, and migration by targeting VEGF in cervical cancer. Moreover, miR-125 negatively regulated VEGF expression in cervical cancer tissues. Finally, we demonstrated that miR-520d-5p inhibited the activation of PI3K/AKT signaling pathway. Conclusion: In conclusion, the findings demonstrated that miR-125 inhibited cervical cancer progression and development by suppression VEGF and PI3K/AKT signaling pathway.

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MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway

Zhang

et al. 2020

World J Surg Onc

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Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma

Rachiglio

Sacco

Forgione

et al. 2020

Exploration of Targeted Anti-Tumor Therapy

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Colorectal carcinoma (CRC) is an heterogeneous disease in which different genetic alterations play a role in its pathogenesis and progression and offer potential for therapeutic intervention. The research on predictive biomarkers in metastatic CRC (mCRC) mainly focused on the identification of biomarkers of response or resistance to anti-epidermal growth factor receptor monoclonal antibodies. In this respect, international guidelines suggest testing mCRC patients only for KRAS, NRAS and BRAF mutations and for microsatellite instability. However, the use of novel testing methods is raising relevant issue related to these biomarkers, such as the presence of sub-clonal RAS mutations or the clinical interpretation of rare no-V600 BRAF variants. In addition, a number of novel biomarkers is emerging from recent studies including amplification of ERBB2, mutations in ERBB2, MAP2K1 and NF1 and rearrangements of ALK, ROS1, NTRK and RET. Mutations in POLE and the levels of tumor mutation burden also appear as possible biomarkers of response to immunotherapy in CRC. Finally, the consensus molecular subtypes classification of CRC based on gene expression profiling has prognostic and predictive implications. Integration of all these information will be likely necessary in the next future in order to improve precision/personalized medicine in mCRC patients.

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Ultra-selection of metastatic colorectal cancer patients using next generation sequencing platform to improve clinical efficacy of anti-EGFR therapy

Cited by 2 publications

References 0 publications

MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway

MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway

Colorectal cancer genomic biomarkers in the clinical management of patients with metastatic colorectal carcinoma

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