Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring

Agaoglu, Sevda; Diep, Priscilla; Martini, Matthew; Kt, Samudhyatha; Baday, Murat; Araci, Ismail Emre

doi:10.1039/c8lc00758f

Cited by 73 publications

(103 citation statements)

References 45 publications

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“…Some attempts have been tried to deliver the drug into middle ear and onto the round window membrane to intensify therapeutic efficacy, however these delivery methods depend on passively diffusing of drugs, which is slow and unpredictable. Similar situation happens for the treatment of eye diseases, such as dry eye, cataract, and glaucoma . The traditional eyedrop delivery in eye relies on manual dripping, which is imprecise and uncomfortable.…”

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

“…They have demonstrated the high efficiency and ability of long‐term usage of the device in guinea pig experiments. Another work reported by Araci et al is not directly related to drug delivery, but it may contribute to the assessment of proper dosing time for some particular diseases involving pressure change of tissues, such as glaucoma. High intraocular pressure is the primary and the only modifiable risk factor of glaucoma .…”

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

“…Another work reported by Araci et al is not directly related to drug delivery, but it may contribute to the assessment of proper dosing time for some particular diseases involving pressure change of tissues, such as glaucoma. High intraocular pressure is the primary and the only modifiable risk factor of glaucoma . However, the conventional monitoring of intraocular pressure is performed at a doctor's office and is not convenient.…”

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

“…However, the conventional monitoring of intraocular pressure is performed at a doctor's office and is not convenient. Araci's team fabricated an ultra‐sensitive microfluidic wearable strain sensor converting small strain changes into a large fluidic volume expansion (Figure B). The senor is embedded in silicone contact lenses without using electronic components.…”

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

“…In health assessment area, wearable microfluidics can provide early warning or dosing notification of some particular diseases. For example, flow rate or wrist pressure abnormal may be related with hypertension, and intraocular pressure signals may remind glaucoma patient to take medicine.…”

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

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Application of Microfluidics in Wearable Devices

et al. 2019

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Wearable devices integrated with various electronic modules, biological sensors, and chemical sensors have drawn large public attention. Due to their inherent advantages of superior stretchability, elaborate microstructure, high integration of multiple functions, and low cost, microfluidics are an excellent candidate and have already been widely used in wearable devices. Well‐designed microfluidic devices can realize excellent multiple functions in wearable devices, including sample collecting, handling and storage, sample analysis, signal converting and amplification, mechanic sensing, and power supplying. Moreover, the microfluidic wearable devices with further integration of wireless modules have exhibited potential applications in healthcare monitoring, clinical assessment, and human and intelligent device interaction. This review focuses on the latest advances on multifunctional wearable devices based on microfluidics, primarily including general functions and designs of microfluidic wearable devices, and their specific applications in physiological signal monitoring, clinical diagnosis and therapeutics, and healthcare.

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Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

Section: Clinical Diagnosis/therapeutics and Healthcarementioning

confidence: 99%

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Application of Microfluidics in Wearable Devices

et al. 2019

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Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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Recent Advances in Smart Contact Lenses

Kim

Cha

Park

2019

Adv Materials Technologies

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The eyes can provide rich physiological information and offer broad diagnostic potential as a sensing site, making the use of contact lens sensors viable for noninvasive monitoring of many diseases and conditions. Therefore, extensive research efforts recently are devoted to the development of smart contact lenses for healthcare monitoring. Herein, physical biomarkers, which can be obtained from the eyes, and chemical biomarkers, which can be obtained from tears are discussed. Then, the latest advances in smart contact lenses with biosensors that diagnose diseases are reviewed. The subsequent content summarizes and classifies the techniques that can be used for the transmission of data based on the methods to deliver physiological information. In addition, representative examples of other devices for drug delivery energy storage are provided, and the challenges that should be overcome to develop smart contact lenses are discussed.

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Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring

Abstract: A passive wearable microfluidic sensor for the 24 hour monitoring of intraocular pressure using a smartphone.

Cited by 73 publications

References 45 publications

Application of Microfluidics in Wearable Devices

Application of Microfluidics in Wearable Devices

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Recent Advances in Smart Contact Lenses

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