Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS

Abstract

This work establishes a hyphenated methodology coupling HPLC with ICP-MS for the determination of platinum chloride complexes as synthetic impurities of platinum-based drugs for the first time. Separation of platinum...

Determination of ultra-trace level Cr(vi) in seawater using large-volume direct injection by LC-ICP-MS with in-line matrix elimination

“…Considering that phosphate is difficult to decompose, there may be problems such as blocking the sampler cone and inhibiting the ionisation efficiency of the plasma. 47,48 Ammonium salts, like ammonium nitrate (NH 4 NO 3 ), readily decompose at high temperatures and are less prone to salt deposition at the cone mouth. So, the NH 4 NO 3 was selected as the mobile phase.…”

Atomic spectrometry update: review of advances in elemental speciation

“…The second paper deals with the analysis by HPLC-ICP-MS of the residual Pt-containing raw materials occurring at trace levels in the final drug preparations of cisplatin, carboplatin and oxaliplatin. 103 The main challenge was to overcome the stark difference in concentration between the final Pt-drug product and the much lower concentration of impurity. The aim being to ensure that the detector is not exposed to very high concentrations of Pt, which would affect the blank signal and have the potential for carry-over effects in the sample introduction system.…”

“…Without any further optimisation, almost baseline resolution of the peaks for arsenate, chromate and molybdate was obtained. The spectrometer was operated in collision mode with He as the bath gas and 4 ISs, 72 Ge, 115 In, 103 Rh, 45 Sc, were added to the mobile phase at concentrations of 100 ng mL −1 . Total element concentrations were also measured by ICP-MS, the procedure for which was validated by the analysis of SPS Spectrapure Standards AS (Oslo, Norway) SPS-SW1 (quality control material for surface water analysis).…”

Atomic spectrometry update: review of advances in the analysis of metals, chemicals and materials

“…The determination of drug metabolites and impurities is clearly an important area of research and Yao et al have provided a study in which platinum chloride impurities in Pt-based drugs were quantified using HPLC-ICP-MS . 74 The separation of inorganic Pt–chloride complexes (K 2 PtCl 4 and K 2 PtCl 6 ) was achieved in less than three minutes on a Hamilton PRP X-100 anion exchange column (15 cm × 4.6 mm) using 2 mmol L −1 hydrochloric acid as the eluent. It should be noted that a matrix elimination series of valves was placed between the end of the column and the ICP-MS instrument.…”