Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy

Li, Bei; Sun, Lan; Li, Tao; Zhang, Yingge; Niu, Xiaoya; You, Zhen

doi:10.1039/d0tb02410d

Cited by 21 publications

(14 citation statements)

References 32 publications

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“…In vivo treatment results fully prove that the nanoprobe has achieved satisfactory therapeutic effects after laser irradiation mediated photothermal/photodynamic combination treatment. The main organs of each treatment group did not show obvious pathological damage, proving that this nanoprobe has excellent in vivo biocompatibility [78].…”

Section: Applications In Cancer Treatmentmentioning

confidence: 83%

“…The nanoparticles functioning as probes, T1 MRI, and in vivo fluorescence imaging modes showed excellent results. These nanoprobes can theoretically escape from the body due to their acid response degradation characteristics [78]. A study about gadolinium-conjugated gold nanoshells in multimodal diagnostic imaging showed their functionality as contrast agents in MRI, X-ray, and three optical imaging methods: OCT, RCM, and TPL.…”

Section: Gadolinium Nanoparticles In Therapymentioning

confidence: 99%

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Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Kouri

Polychronidou

Loukas

et al. 2023

JNT

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The multifactorial nature of cancer still classifies the disease as one of the leading causes of death worldwide. Modern medical sciences are following an interdisciplinary approach that has been fueled by the nanoscale revolution of the past years. The exploitation of high-Z materials, in combination with ionizing or non-ionizing radiation, promises to overcome restrictions in medical imaging and to augment the efficacy of current therapeutic modalities. Gold nanoparticles (AuNPs) have proven their value among the scientific community in various therapeutic and diagnostic techniques. However, the high level of multiparametric demands of AuNP experiments in combination with their biocompatibility and cytotoxicity levels remain crucial issues. Gadolinium NPs (GdNPs), have presented high biocompatibility, low cytotoxicity, and excellent hemocompatibility, and have been utilized in MRI-guided radiotherapy, photodynamic and photothermal therapy, etc. Τhe utilization of gadolinium bound to AuNPs may be a promising alternative that would reduce phenomena, such as toxicity, aggregation, etc., and could create a multimodal in vivo contrast and therapeutic agent. This review highlights multi-functionalization strategies against cancer where gold and gadolinium NPs are implicated. Their experimental applications and limitations of the past 5 years will be analyzed in the hope of enlightening the benefits and drawbacks of their proper combination.

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Section: Applications In Cancer Treatmentmentioning

confidence: 83%

Section: Gadolinium Nanoparticles In Therapymentioning

confidence: 99%

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Kouri

Polychronidou

Loukas

et al. 2023

JNT

View full text Add to dashboard Cite

show abstract

“…In vivo investigations showed that the nanomaterials attainted improved synergistic PDT-PTT therapies under laser treatments and effectively reduced tumor growth. From this study, it concludes that the gold nanostructure-based nanosystem has great efficiency against liver cancer with a dual imaging system [ 196 ]. Synergistic phototherapies have been shown to encourage therapeutic efficiency against various types of cancers.…”

Section: Synergetic Phototherapies Based On Gold Nanostructuresmentioning

confidence: 99%

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Sekar¹,

Basavegowda

Thathapudi

et al. 2023

Pharmaceutics

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Cancer is one of the most dangerous health problems in the millennium and it is the third foremost human cause of death in the universe. Traditional cancer treatments face several disadvantages and cannot often afford adequate outcomes. It has been exhibited that the outcome of several therapies can be improved when associated with nanostructures. In addition, a modern tendency is being developed in cancer therapy to convert single-modal into multi-modal therapies with the help of existing various nanostructures. Among them, gold is the most successful nanostructure for biomedical applications due to its flexibility in preparation, stabilization, surface modifications, less cytotoxicity, and ease of bio-detection. In the past few decades, gold-based nanomaterials rule cancer treatment applications, currently, gold nanostructures were the leading nanomaterials for synergetic cancer therapies. In this review article, the synthesis, stabilization, and optical properties of gold nanostructures have been discussed. Then, the surface modifications and targeting mechanisms of gold nanomaterials will be described. Recent signs of progress in the application of gold nanomaterials for synergetic cancer therapies such as photodynamic and photo-thermal therapies in combination with other common interventions such as radiotherapy, chemotherapy, and will be reviewed. Also, a summary of the pharmacokinetics of gold nanostructures will be delivered. Finally, the challenges and outlooks of the gold nanostructures in the clinics for applications in cancer treatments are debated.

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“…Furthermore, spherical gold nanoparticles can also self-assemble into three-dimensional nanostructures for cancer treatment. In a recent study, You’s group reported nanoprobes formed by self-assembly of ultrasmall AuNPs for dual-mode real-time imaging-guided photothermal/photodynamic combined therapy for liver cancer [ 36 ]. The nanoprobes demonstrated excellent tumor-targeting capabilities in both T1 magnetic-resonance imaging and in vivo fluorescence imaging modes; meanwhile, the nanoprobes are able to dissociate and escape from the body to reduce aggregation in the body to minimize the possible toxicity [ 36 ].…”

Section: Gold Nanostructures For Cancer Treatmentmentioning

confidence: 99%

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters

Wang¹,

Shen

et al. 2022

Nanomaterials

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Cancer is a major global health issue and is a leading cause of mortality. It has been documented that various conventional treatments can be enhanced by incorporation with nanomaterials. Thanks to their rich optical properties, excellent biocompatibility, and tunable chemical reactivities, gold nanostructures have been gaining more and more research attention for cancer treatment in recent decades. In this review, we first summarize the recent progress in employing three typical gold nanostructures, namely spherical Au nanoparticles, Au nanorods, and atomically precise Au nanoclusters, for cancer diagnostics and therapeutics. Following that, the challenges and the future perspectives of this field are discussed. Finally, a brief conclusion is summarized at the end.

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Ultra-small gold nanoparticles self-assembled by gadolinium ions for enhanced photothermal/photodynamic liver cancer therapy

Abstract: Gold nanomaterials are widely used in biomedical research as drug delivery systems, imaging agents and therapeutic materials owing to their unique physicochemical properties and high biocompatibility.

Cited by 21 publications

References 32 publications

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Consolidation of Gold and Gadolinium Nanoparticles: An Extra Step towards Improving Cancer Imaging and Therapy

Recent Progress of Gold-Based Nanostructures towards Future Emblem of Photo-Triggered Cancer Theranostics: A Special Focus on Combinatorial Phototherapies

Engineering Gold Nanostructures for Cancer Treatment: Spherical Nanoparticles, Nanorods, and Atomically Precise Nanoclusters

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