Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

Liu, Teng; Chao, Yu; Gao, Min; Liang, Chao; Chen, Qian; Song, Guosheng; Cheng, Liang; Liu, Zhuang

doi:10.1007/s12274-016-1183-x

Cited by 146 publications

(126 citation statements)

References 53 publications

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“…27,28 On the other hand, integration of multiple imaging and therapy functions within such ultrasmall nanoscale structures often would require relatively complicated design and fabrication processes. 29,30 Hence, it would be of great interests to develop simple methods for the fabrication of multifunctional nanoparticles with ultrasmall hydrodynamic sizes in physiological conditions such as the plasma environment, so as to enable rapid renal clearance of those nanoparticles from the body, after their missions in cancer imaging and enhanced therapy are accomplished.…”

mentioning

confidence: 99%

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

et al. 2017

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Developing tumor-homing nanoparticles with integrated diagnostic and therapeutic functions, and in the meanwhile could be rapidly excreted from the body, would be of great interests to realize imaging-guided precision treatment of cancer. In this study, a kind of ultrasmall coordination polymer nanodots (CPNs) based on the coordination between tungsten ions (WVI) and gallic acid (W-GA) was developed via a simple method. After polyethylene glycol (PEG) modification, PEGylated W-GA (W-GA-PEG) CPNs with an ultrasmall hydrodynamic diameter of 5 nm were rather stable in various physiological solutions. Without the need of chelator molecules, W-GA-PEG CPNs could be efficiently labeled with radioisotope 64Cu2+, enabling positron emission tomography (PET) imaging, which reveals efficient tumor accumulation and rapid renal clearance of W-GA-PEG CPNs upon intravenous injection. Utilizing the radio-sensitizing function of tungsten with strong X-ray absorption, such W-GA-PEG CPNs were able to greatly enhance the efficacy of cancer radiotherapy in inhibiting the tumor growth. With fast clearance and little long-term body retention, those W-GA-PEG CPNs exhibited no appreciable in vivo toxicity. This study presents a type of CPNs with excellent imaging and therapeutic abilities as well as rapid renal clearance behavior, promising for further clinic translation.

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confidence: 99%

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

et al. 2017

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“…46 With nanocarriers of suitable size (20-100 nm), it is possible to utilize fully the enhanced permeability and retention (EPR) effect 47 while avoiding extravasation from normal blood vessels (for particles below 10 nm) 48 and removal from body through renal clearance (for particles below 5 nm) or elimination by the reticuloendothelial system (RES, for particles larger than 100 nm). 49 The EPR effect is caused by 1) tumor angiogenesis, where the newly formed blood vessels are underdeveloped and contain large pores, making them leaky, thus increasing accumulation of nanoparticles in tumor tissue; and 2) lack of lymphatic vessels in tumors, thus increasing retention of nanoparticles in the tissue. 50 Moreover, there are various modes of entry to cells with which nanoparticles can engage, ie, clathrin-or caveolaemediated endocytosis, phagocytosis, or macropinocytosis.…”

Section: Structural Changes In Apodoxmentioning

confidence: 99%

“…However, this storage temperature is not suitable for use in patients, since ApoDox stored at -20°C creates very large aggregates that would be removed rapidly from the body by the RES. 49 All cells had died after 68 hours of treatment with ApoDox stored at 4°C and in dark ( Figure 8 [cyan]), which was slightly better than in the case of freshly prepared ApoDox. Moreover, storage at this temperature showed the highest stability with regard to size, shape, and surface charge.…”

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confidence: 99%

Apoferritin as an ubiquitous nanocarrier with excellent shelf life

Dostálová¹,

Vašíčková²,

Hynek³

et al. 2017

IJN

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Due to many adverse effects of conventional chemotherapy, novel methods of targeting drugs to cancer cells are being investigated. Nanosize carriers are a suitable platform for this specific delivery. Herein, we evaluated the long-term stability of the naturally found protein nanocarrier apoferritin (Apo) with encapsulated doxorubicin (Dox). The encapsulation was performed using Apo’s ability to disassemble reversibly into its subunits at low pH (2.7) and reassemble in neutral pH (7.2), physically entrapping drug molecules in its cavity (creating ApoDox). In this study, ApoDox was prepared in water and phosphate-buffered saline and stored for 12 weeks in various conditions (−20°C, 4°C, 20°C, and 37°C in dark, and 4°C and 20°C under ambient light). During storage, a very low amount of prematurely released drug molecules were detected (maximum of 7.5% for ApoDox prepared in PBS and 4.4% for ApoDox prepared in water). Fourier-transform infrared spectra revealed no significant differences in any of the samples after storage. Most of the ApoDox prepared in phosphate-buffered saline and ApoDox prepared in water and stored at −20°C formed very large aggregates (up to 487% of original size). Only ApoDox prepared in water and stored at 4°C showed no significant increase in size or shape. Although this storage caused slower internalization to LNCaP prostate cancer cells, ApoDox (2.5 μM of Dox) still retained its ability to inhibit completely the growth of 1.5×10 4 LNCaP cells after 72 hours. ApoDox stored at 20°C and 37°C in water was not able to deliver Dox inside the nucleus, and thus did not inhibit the growth of the LNCaP cells. Overall, our study demonstrates that ApoDox has very good stability over the course of 12 weeks when stored properly (at 4°C), and is thus suitable for use as a nanocarrier in the specific delivery of anticancer drugs to patients.

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“…But glycine-Cys coated AuNPs showed much higher physiological stability and renalclearance efficiency, indicated the importance of the ligand length in the physiological stability and renal clearance of NPs. 55 dispersity in water with HDs of 21.0 nm, 11.7 nm and 7.5 nm, respectively 21 . It was demonstrated that Cys-MoS 2 was not stable in physiological solutions, transforming to a turbid solution after the incubation in PBS.…”

Section: Surface Chemistry and Serum Protein Absorptionmentioning

confidence: 99%

“…15,16,19 The reasonable engineering of NPs by tuning physicochemical properties can promote their evasion from RES absorption, leading to the change of biodistribution and the reduction of biological toxicity. 1,20 Recent studies have demonstrated the great potential applications of renal-clearable luminescent metal NPs in various disease theranostics such as cancer [21][22][23] and kidney dysfunction 24 . In this review, we will summarize the influences on the synthetic strategies and optical properties of renalclearable luminescent metal NPs, the pharmacokinetics and biodistribution features, and their recent bioapplications.…”

Section: Introductionmentioning

confidence: 99%

Bioapplications of renal-clearable luminescent metal nanoparticles

Gong

Wang

2017

Biomater. Sci.

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Renal-clearable inorganic nanoparticles (NPs) that hold great potential in the future clinic translations are considered as the next generation of nanomedicine. In the past decade, enormous efforts have been dedicated to the development of renal-clearable NPs with fascinating optical properties, selective disease-targeting capabilities and low nanotoxicities. A further understanding of the design of renal-clearable luminescent metal NPs and their metabolic behavior in the body is important to achieve their clinical transition and extend their bioapplications in disease theranostics. In this review, we discuss the recent synthetic strategies of renal-clearable metal NPs in terms of the considerations of size and composition, surface chemistry and emission wavelength. We also summarize the current disease-related applications of these renal-clearable luminescent metal NPs in tumor targeting, kidney disease and antimicrobial investigations after a discussion of their biological behavior including the pharmacokinetics and biodistribution. Finally, we provide perspectives on the current challenges and upcoming chances for renal-clearable luminescent metal NPs.

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Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

Cited by 146 publications

References 53 publications

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

Apoferritin as an ubiquitous nanocarrier with excellent shelf life

Bioapplications of renal-clearable luminescent metal nanoparticles

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Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy

Cited by 146 publications

References 53 publications

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

Apoferritin as an ubiquitous nanocarrier with excellent shelf life

Bioapplications of renal-clearable luminescent metal nanoparticles

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Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer

Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free ⁶⁴Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer