Ultra-trace analysis of 12 β2-agonists in pork, beef, mutton and chicken by ultrahigh-performance liquid-chromatography–quadrupole-orbitrap tandem mass spectrometry

Guo, Changchuan; Shi, Feng; Gong, Lei; Tan, Huijie; Hu, Defu; Zhang, Jinling

doi:10.1016/j.jpba.2015.01.048

Cited by 38 publications

(15 citation statements)

References 23 publications

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“…Q-Orbitrap based HRMS offers comparable quantitation performance with sensitivity at sub ng mL À1 levels. HPLC-Q-Orbitrap HRMS has recently been applied to b-agonist analysis (Guo et al, 2015;Leon et al, 2012;Wang et al, 2014). Orbitrap based HRMS can generate full scan mass spectra with mass resolution higher than 100,000 and mass accuracy better than 5 ppm.…”

Section: Compoundsmentioning

confidence: 99%

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search

Cao

et al. 2016

Food Chemistry

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Section: Compoundsmentioning

confidence: 99%

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search

Cao

et al. 2016

Food Chemistry

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“…The stability was represented by a percentage of the initial concentration of the analyte in spiked samples. 28…”

Section: Postpreparation Stabilitymentioning

confidence: 53%

“…Postpreparation stability of the analytes was evaluated by storing the spiked samples at screening concentration in autosampler (15°C) for 24 hours. The stability was represented by a percentage of the initial concentration of the analyte in spiked samples …”

Section: Methodsmentioning

confidence: 99%

Multiclass and multiresidue screening of veterinary drugs and pesticides in infant formula using Quadrupole‐Orbitrap MS with PRM scan mode

Zhang¹,

Zhang²,

Zhang³

et al. 2020

J Mass Spectrom

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A multiclass and multiresidue method for screening veterinary drugs and pesticides in infant formula was developed and validated using ultrahigh‐performance liquid chromatography coupled to Quadrupole‐Orbitrap high‐resolution mass spectrometry (UHPLC‐HRMS). A total of 49 veterinary drugs and pesticides investigated belong to 11 classes including antivirals, anticoccidials, macrolides, pyrethroids, insecticides, sulfonamides, beta‐agonists, sedatives, thyreostats, nonsteroidal anti‐inflammatory drugs, and other pharmacologically active substances. A generic sample preparation and highly selective acquisition mode of parallel reaction monitoring (PRM) were deliberately incorporated to perform efficient screening analysis. As a result, the screening target concentrations of the analytes varied from 1 to 500 μg/kg with ≤5% of false compliant rate as specified in Decision 2002/657/EC for screening analysis. The average recoveries ranged from 40.7 to 124.9% as well as the relative standard deviations from 4.2 to 26.6%, respectively. The matrix effects and interferences were effectively controlled by integrated application of dispersive solid phase extraction, PRM scan mode, and matrix‐matched standard calibration. The proposed method will be helpful to provide applicable strategy for screening residues in infant formula with surveillance purpose.

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“…Several research groups evaluated MS settings during DDA mode in order to examine their significance in the experimental outcome and optimize instrument performance for a successful analysis. In terms of MS parameters, the effect of dynamic exclusion, signal thresholds setting to trigger an MS/MS event, mass resolving power, ion injection time, number of MS/MS, monoisotopic precursor selection, preview mode for FTMS scan, normalized collision energy, automatic gain control (AGC) target for MS and MS/MS scans, and number of microscans have been evaluated and discussed, aiming to examine the significance and effect of instrument settings on identification rates. These reports revealed that MS settings influence identification rates and improved results can be obtained by optimizing instrument performance .…”

Section: Resultsmentioning

confidence: 99%

“…Until now, several studies have been reported application of the hybrid instrument Q-Exactive in the field of food quality and safety. [12][13][14][15][16] However, in literature, there are no data about extraction methods of most used plastic additives and BPA from complex food.…”

mentioning

confidence: 99%

Optimization of mass spectrometry acquisition parameters for determination of polycarbonate additives, degradation products, and colorants migrating from food contact materials to chocolate

et al. 2017

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The interest towards "substances of emerging concerns" referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to high resolution mass spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers. The optimization of mass spectrometric parameter settings for quantitative analysis of additives has been achieved by a chemometric approach, using a full factorial and d-optimal experimental designs, allowing to evaluate possible interactions between the investigated parameters. Results showed that the optimized method was characterized by improved features in terms of sensitivity respect to existing methods and was successfully applied to the analysis of a complex model food system such as chocolate put in contact with 14 polycarbonate tableware samples. A new procedure for sample pre-treatment was carried out and validated, showing high reliability. Results reported, for the first time, the presence of several molecules migrating to chocolate, in particular belonging to plastic additives, such Cyasorb UV5411, Tinuvin 234, Uvitex OB, and oligomers, whose amount was found to be correlated to age and degree of damage of the containers.

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Ultra-trace analysis of 12 β2-agonists in pork, beef, mutton and chicken by ultrahigh-performance liquid-chromatography–quadrupole-orbitrap tandem mass spectrometry

Cited by 38 publications

References 23 publications

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search

Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search

Multiclass and multiresidue screening of veterinary drugs and pesticides in infant formula using Quadrupole‐Orbitrap MS with PRM scan mode

Optimization of mass spectrometry acquisition parameters for determination of polycarbonate additives, degradation products, and colorants migrating from food contact materials to chocolate

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