Ultra-trace determination of sodium fluoroacetate (1080) as monofluoroacetate in milk and milk powder by GC-MS/MS and LC-MS/MS

Wong, Yiu‐Tung; Law, Wing-Ki; Lai, Shirley Sau-Ling; Wong, Siu-Pan; Lau, Kong-Chi; Ho, Clare

doi:10.1039/c8ay00767e

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Moreover, preventing high back pressure is difficult due to the tight packing of the SPE filler. Thus, SPE is combined with other extraction or clean-up procedures, such as LLE and ASE, to obtain more accurate results [33][34][35][36][37][38][39][40].…”

Section: Spementioning

confidence: 99%

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Gao

Wang³

et al. 2021

Foods

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Food safety and quality have been gaining increasing attention in recent years. Gas chromatography coupled to tandem mass spectrometry (GC–MS/MS), a highly sensitive technique, is gradually being preferred to GC–MS in food safety laboratories since it provides a greater degree of separation on contaminants. In the analysis of food contaminants, sample preparation steps are crucial. The extraction of multiple target analytes simultaneously has become a new trend. Thus, multi-residue analytical methods, such as QuEChERs and adsorption extraction, are fast, simple, cheap, effective, robust, and safe. The number of microorganic contaminants has been increasing worldwide in recent years and are considered contaminants of emerging concern. High separation in MS/MS might be, in certain cases, favored to sample preparation selectivity. The ideal sample extraction procedure and purification method should take into account the contaminants of interest. Moreover, these methods should cooperate with high-resolution MS, and other sensitive full scan MSs that can produce a more comprehensive detection of contaminants in foods. In this review, we discuss the most recent trends in preparation methods for highly effective detection and analysis of food contaminants, which can be considered tools in the control of food quality and safety.

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Section: Spementioning

confidence: 99%

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Gao

Wang³

et al. 2021

Foods

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“…Current methodologies employed to detect and quantitate MFA include both liquid and gas chromatography (GC) with and without derivatization. Liquid chromatography methods have relied on fluorescence detection or tandem mass spectrometry (MS/MS) with derivatization 6–8 or without derivatization 9‐12 . GC methods based on flame ionization detection and single quadrupole MS with various types of derivatization such as alkylation with pentafluorobenzyl bromide (PFBBr), 13,14 esterification with acidic ethanol 15 and acidic n ‐propanol, 16 and coupling with 2,4‐dichloroaniline in the presence of dicyclohexylcarbodiimide 17,18 have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Liquid chromatography methods have relied on fluorescence detection or tandem mass spectrometry (MS/MS) with derivatization [6][7][8] or without derivatization. [9][10][11][12] GC methods based on flame ionization detection and single quadrupole MS with various types of derivatization such as alkylation with pentafluorobenzyl bromide (PFBBr), 13,14 esterification with acidic ethanol 15 and acidic n-propanol, 16 and coupling with 2,4-dichloroaniline in the presence of dicyclohexylcarbodiimide 17,18 have been reported. 12 Here, we describe a simple modification of the aforementioned analytical techniques for the development of an easy, two-step extraction and derivatization method with well-defined, highly specific multiple reaction monitoring (MRM) transitions specific for the detection of a pentafluorobenzyl (PFB) derivative of MFA using GC/MS/MS.…”

Section: Introductionmentioning

confidence: 99%

Pentafluorobenzylation and detection of sodium monofluoroacetate (compound 1080) in veterinary samples using gas chromatography/tandem quadrupole mass spectrometry with multiple reaction monitoring

Buchweitz

Johnson

Lehner

2021

Rapid Comm Mass Spectrometry

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The analytical detection of chemical residues from sodium monofluoroacetate (MFA) ingestion in targeted predatory wildlife and in pesticide misuse incidents perpetrated against nuisance companion animals remains a concern in veterinary forensic toxicology. There is a current need for chemically stable sample extracts with reliable and specific diagnostic methods for trace quantities in diverse diagnostic matrices. Methods: Biphasic pentafluorobenzylation provided a simple combined extraction and derivatization procedure for removing MFA in a chemically stable form from a complex matrix such as stomach contents. Analysis of the derivatized extract using gas chromatography/tandem quadrupole mass spectrometry (GC/MS/MS) with multiple reaction monitoring (MRM) approaches specific to MFA provided greater specificity than simple scan or selected ion monitoring approaches. Results: Collision-induced dissociation in GC/MS/MS showed that pentafluorobenzyl (PFB)-derivatized MFA (M + m/z 258) generated m/z 258à130, 149, 161, 177, 178, 180.1, and 181.1 transitions. Of these, the transition m/z 258à181 provided a peak for quantitation, whereas m/z 258à161 and 258à178 provided specificity for qualifying MFA. Similarly, PFB-derivatized 2-chloropropionic acid (M + m/z 288) was used as an internal standard, which generated m/z 288à181 and 161. Of these, the transition m/z 288à181 provided a peak for quantitation, whereas m/z 288à161 and 181à161 served to qualify the internal standard. Conclusions: The method was validated with a calculated limit of detection of 0.35 ppm and limit of quantitation of 1.09 ppm MFA. The method should have adequate sensitivity and reliability for veterinary toxicology labs analyzing specimens from animals poisoned by this predacide.

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“…[15][16][17][18] These studies have been complemented by novel strategies to identify 1080 contamination in food and water sources. 19,20 However, despite ongoing research, there is still no reliable treatment for intoxication.…”

Section: Introductionmentioning

confidence: 99%

“…In the past 10 years, the identification of 1080 intoxication in livestock and domesticated animals has continued to be a focus 15–18 . These studies have been complemented by novel strategies to identify 1080 contamination in food and water sources 19,20 . However, despite ongoing research, there is still no reliable treatment for intoxication.…”

Section: Introductionmentioning

confidence: 99%

Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning

Cox

Hartog

Pueblo

et al. 2020

Annals of the New York Academy of Sciences

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Fluoroacetate (FA) is a tasteless, odorless, water-soluble metabolic poison with severe toxicological effects. Characterized in the mid-1900s, it has been used as a rodenticide but is comparably lethal to all mammals. Many countries have restricted its use, and modern-day accidental human exposures are rare, but recently, concerns have been raised about its application as a chemical weapon with no known antidote. A combined treatment of methylene blue (MB), an antioxidant, and monosodium glutamate (MSG), a precursor of the citric acid cycle substrate alphaketoglutarate, has been recommended as an effective countermeasure; however, no peer-reviewed articles documenting the efficacy of this therapy have been published. Using a rodent model, we assessed the effects of MB and MSG on the neurologic, cardiac, and pulmonary systems. Transcriptomic analysis was used to elucidate inflammatory pathway activation and guide bioassays, which revealed the advantages and disadvantages of these candidate countermeasures. Results show that MB and MSG can reduce neurologic signs observed in rats exposed to sodium FA and improve some effects of intoxication. However, while this strategy resolved some signs of intoxication, ultimately it was unable to significantly reduce lethality.

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Ultra-trace determination of sodium fluoroacetate (1080) as monofluoroacetate in milk and milk powder by GC-MS/MS and LC-MS/MS

Abstract: A sensitive analytical method based on derivatization with 3-nitroaniline is established for the trace determination of sodium fluoroacetate (1080) in milk and milk powder.

Cited by 6 publications

References 33 publications

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Comprehensive Strategy for Sample Preparation for the Analysis of Food Contaminants and Residues by GC–MS/MS: A Review of Recent Research Trends

Pentafluorobenzylation and detection of sodium monofluoroacetate (compound 1080) in veterinary samples using gas chromatography/tandem quadrupole mass spectrometry with multiple reaction monitoring

Methylene blue and monosodium glutamate improve neurologic signs after fluoroacetate poisoning

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