Ultra-trace level determination of neonicotinoids in honey as a tool for assessing environmental contamination

Kammoun, Souad; Mulhauser, Blaise; Aebi, Alexandre; Mitchell, Edward A. D.; Glauser, Gaëtan

doi:10.1016/j.envpol.2019.02.004

Cited by 35 publications

(14 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The gradient program started at 0% phase B and increased linearly to 37.5% in 7.5 min, followed by a rapid increase to 100% B in 0.5 min, wash at 100% B for 2 min and reequilibration at 0% B for 4 min. The MS source conditions were identical to those presented in Kammoun and colleagues [ 33 ] except that the MS was operated in both electrospray positive and negative ionization using a 20 ms polarity switching time. Neonicotinoids were monitored based on the multiple reaction monitoring (MRM) mode.…”

Section: Methodsmentioning

confidence: 99%

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background Neonicotinoids (NN) are selective neurotoxic pesticides that bind to insect but also mammal nicotinic acetycholine receptors (nAChRs). As the most widely used class of insecticides worldwide, they are ubiquitously found in the environment, wildlife, and foods, and thus of special concern for their impacts on the environment and human health. nAChRs are vital to proper brain organization during the prenatal period and play important roles in various motor, emotional, and cognitive functions. Little is known on children’s contamination by NN. In a pilot study we tested the hypothesis that children’s cerebro-spinal fluid (CSF) can be contaminated by NN. Methods NN were analysed in leftover CSF, blood, and urine samples from children treated for leukaemias and lymphomas and undergoing therapeutic lumbar punctions. We monitored all neonicotinoids approved on the global market and some of their most common metabolites by ultra-high performance liquid chromatography-tandem mass spectrometry. Results From August to December 2020, 14 children were consecutively included in the study. Median age was 8 years (range 3–18). All CSF and plasma samples were positive for at least one NN. Nine (64%) CSF samples and 13 (93%) plasma samples contained more than one NN. Thirteen (93%) CSF samples had N-desmethyl-acetamiprid (median concentration 0.0123, range 0.0024–0.1068 ng/mL), the major metabolite of acetamiprid. All but one urine samples were positive for ≥ one NN. A statistically significant linear relationship was found between plasma/urine and CSF N-desmethyl-acetamiprid concentrations. Conclusions We have developed a reliable analytical method that revealed multiple NN and/or their metabolites in children’s CSF, plasma, and urine. Our data suggest that contamination by multiple NN is not only an environmental hazard for non-target insects such as bees but also potentially for children.

show abstract

Section: Methodsmentioning

confidence: 99%

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In honeybees and wild bees (including bumblebees), the detrimental effects of pesticides and insecticides have been studied as non-target effects on these important pollinators, and thus, in the light of conservation. In addition, the accumulation of pesticides (and to a lesser extent, heavy metals) in beeswax and honey has received much attention [31,37,38,40,70,[99][100][101][102][103][104][105][106][107]. Since pollutants may reach the human consumer via these bee products, they may be used for biomonitoring of the environment, and most importantly, may mediate detrimental effects upon offspring, resulting in colony-level detrimental effects.…”

Section: Major Classes Of Pollutants Threatening Social Insectsmentioning

confidence: 99%

Pollutants and Their Interaction with Diseases of Social Hymenoptera

Feldhaar

Otti

2020

Insects

View full text Add to dashboard Cite

Many insect species, including social insects, are currently declining in abundance and diversity. Pollutants such as pesticides, heavy metals, or airborne fine particulate matter from agricultural and industrial sources are among the factors driving this decline. While these pollutants can have direct detrimental effects, they can also result in negative interactive effects when social insects are simultaneously exposed to multiple stressors. For example, sublethal effects of pollutants can increase the disease susceptibility of social insects, and thereby jeopardize their survival. Here we review how pesticides, heavy metals, or airborne fine particulate matter interact with social insect physiology and especially the insects’ immune system. We then give an overview of the current knowledge of the interactive effects of these pollutants with pathogens or parasites. While the effects of pesticide exposure on social insects and their interactions with pathogens have been relatively well studied, the effects of other pollutants, such as heavy metals in soil or fine particulate matter from combustion, vehicular transport, agriculture, and coal mining are still largely unknown. We therefore provide an overview of urgently needed knowledge in order to mitigate the decline of social insects.

show abstract

“…For sample preparation, various pretreatment methods were used for pesticide analysis, such as liquid-liquid extraction (LLE), 22,24 solid-phase extraction (SPE), 25 magnetic solid-phase extraction (MSPE), 26,27 dispersive liquid-liquid microextraction (DLLME) 28 and solidphase microextraction (SPME), 29 and so on. Compared with other pretreatment technique, quick, easy, cheap, rugged, effective, and safe (QuEChERS) 21,[30][31][32] method has the advantages of simple and fast operation, requirement of less solvent in the extraction process, and less environmental pollution. This is followed by a salting-out step, causing the partitioning of two liquid phases.…”

Section: Introductionmentioning

confidence: 99%