Ultrabroad Bandwidth and Highly Sensitive Optical Ultrasonic Detector for Photoacoustic Imaging

Zhang, Cheng; Ling, Tao; Chen, Sung Liang; Guo, L. Jay

doi:10.1021/ph500159g

Cited by 111 publications

(93 citation statements)

References 37 publications

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“…Micro-ring resonator has been demonstrated as a high-performance ultrasound detector with both broad bandwidth and great detection sensitivity. Our previous studies have shown that the micro-ring detector has an intrinsic acoustic response from nearly DC up to 350MHz at −3dB [22], and a noise equivalent detectable pressure over this bandwidth as low as 105 Pa. This sensitivity is comparable to or even better than those of conventional piezoelectric transducers.…”

Section: Introductionmentioning

confidence: 94%

“…Micro-ring has been utilized in highresolution PA imaging [27,28], as well as real-time THz pulse detection [29]. The device has demonstrated an ultra-broadband intrinsic frequency response from nearly DC to 350 MHz at −3dB [22]. However, the whole system response bandwidth is not only limited by the bandwidth of the photodetector but also by the duration of the laser pulses.…”

Section: Principlesmentioning

confidence: 99%

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Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector

Tian

Zhang

et al. 2016

Opt. Express

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Photoacoustic spectrum analysis (PASA) has been demonstrated as a new method for quantitative tissue imaging and characterization. The ability of PASA in evaluating microsize tissue features was limited by the bandwidth of detectors for photoacoustic (PA) signal acquisition. We improve upon such a limit, and report on developments of PASA facilitated by an optical ultrasonic detector based on micro-ring resonator. The detector's broad and flat frequency response significantly improves the performance of PASA and extents its characterization capability from the tissue level to cellular level. The performance of the system in characterizing cellular level (a few microns) stochastic objects was first shown via a study on size-controlled optically absorbing phantoms. As a further demonstration of PASA's potential clinical application, it was employed to characterize the morphological changes of red blood cells (RBCs) from a biconcave shape to a spherical shape as a result of aging. This work demonstrates that PASA equipped with the micro-ring ultrasonic detectors is an effective technique in characterizing cellular-level micro-features of biological samples.

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Section: Introductionmentioning

confidence: 94%

Section: Principlesmentioning

confidence: 99%

Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector

Tian

Zhang

et al. 2016

Opt. Express

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“…38 Chen et al used polymer micro-ring resonator as a PA signal detection system, the detection bandwidth up to 90 MHz, to achieve highresolution imaging of biological tissue. [39][40][41] In order to achieve the noncontact detection of ultrasonic signals, Wang Yi et al employed the low coherence Michelson interferometer (the detection bandwidth up to 17 MHz) achieving noncontact PA signal detection. 28 In 2012, Cedric Blatter adopted phasesensitive optical coherence tomography system to realize the noncontact measurements of PA signals (the bandwidth of 13 MHz), and acquired PA and OCT images of simulated samples.…”

Section: All-optical Pa Detectionmentioning

confidence: 99%

All-optically integrated photoacoustic and optical coherence tomography: A review

Qiao

Chen

2017

J. Innov. Opt. Health Sci.

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All-optically integrated photoacoustic (PA) and optical coherence tomography (OCT) dualmode imaging technology that could o®er comprehensive pathological information for accurate diagnosis in clinic has gradually become a promising imaging technology in the aspect of biomedical imaging during the recent years. This review refers to the technology aspects of alloptical PA detection and system evolution of optically integrated PA and OCT, including Michelson interferometer dual-mode imaging system, Fabry-Perot (FP) interferometer dualmode imaging system and Mach-Zehnder interferometer dual-mode imaging system. It is believed that the optically integrated PA and OCT has great potential applications in biomedical imaging.

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“…While broad-band detection can be achieved with polyvinylidene-fluorid-based (PVDF) hydrophones, for the most sensitive PZT transducers, the BW is typically on the same order of magnitude as the center frequency, resulting in narrow bandwidths, especially if highly sensitive detection of frequencies below 10 MHz is required. In photoacoustic imaging, artifacts are created by the simultaneous detection of small and large structures, where both high-and low-frequency spectral components are integrated for image reconstruction [8,9]. Therefore, a sensor with a high sensitivity to low-and high-frequency spectral components would be best suited for PAI.…”

Section: Introductionmentioning

confidence: 99%

All-optical highly sensitive akinetic sensor for ultrasound detection and photoacoustic imaging

Preißer¹,

Rohringer²,

et al. 2016

Biomed. Opt. Express

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A novel all-optical akinetic ultrasound sensor, consisting of a rigid, fiber-coupled Fabry-Pérot etalon with a transparent central opening is presented. The sensing principle relies exclusively on the detection of pressure-induced changes of the refractive index in the fluid filling the Fabry-Pérot cavity. This enables resonance-free, inherently linear signal detection over a broad bandwidth. We demonstrate that the sensor achieves a exceptionally low peak noise equivalent pressure (NEP) values of 2 Pa over a 20 MHz measurement bandwidth (without signal averaging), while maintaining a flat frequency response, and a detection bandwidth up to 22.5 MHz (-6 dB). The measured large full field of view of the sensor is 2.7 mm × 1.3 mm and the dynamic range is 137 dB/ √ Hz or 63 dB at 20 MHz bandwidth. For different required amplitude ranges the upper amplitude detection limit can be customized from at least 2 kPa to 2 MPa by using cavity mirrors with a lower optical reflectivity. Imaging tests on a resolution target and on biological tissue show the excellent suitability of the akinetic sensor for optical resolution photoacoustic microscopy (OR-PAM) applications. functional photoacoustic microscopy of mouse brain in action," Nat. Methods 12, 407-410 (2015). 7. L. Xi, C. Song, and H. Jiang, "Confocal photoacoustic microscopy using a single multifunctional lens," Opt. Lett. 39, 3328-3331 (2014). 8. J. Gateau, A. Chekkoury, and V. Ntziachristos, "Ultra-wideband three-dimensional optoacoustic tomography," Opt.Lett. 38, 4671-4674 (2013). 9. C. Zhang, T. Ling, S.-L. Chen, and L. J. Guo, "Ultrabroad bandwidth and highly sensitive optical ultrasonic detector for photoacoustic imaging," ACS Photonics 1, 1093-1098 (2014). 10. E. Zhang, J. Laufer, and P. Beard, "Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Pérot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues," Appl. Opt. photoacoustic microscopy using a digital micromirror device," Opt. Lett. 38, 1683-2686 (2013).

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Ultrabroad Bandwidth and Highly Sensitive Optical Ultrasonic Detector for Photoacoustic Imaging

Cited by 111 publications

References 37 publications

Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector

Characterizing cellular morphology by photoacoustic spectrum analysis with an ultra-broadband optical ultrasonic detector

All-optically integrated photoacoustic and optical coherence tomography: A review

All-optical highly sensitive akinetic sensor for ultrasound detection and photoacoustic imaging

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