We show that density-dependent synthetic gauge fields may be engineered by combining periodically modulated interactions and Raman-assisted hopping in spin-dependent optical lattices. These fields lead to a density-dependent shift of the momentum distribution, may induce superfluid-to-Mott insulator transitions, and strongly modify correlations in the superfluid regime. We show that the interplay between the created gauge field and the broken sublattice symmetry results, as well, in an intriguing behavior at vanishing interactions, characterized by the appearance of a fractional Mott insulator. DOI: 10.1103/PhysRevLett.113.215303 PACS numbers: 67.85.-d, 03.65.Vf, 03.75.Lm, 37.10.Jk The emulation of synthetic electromagnetism in cold neutral gases has attracted major interest [1,2]. Artificial electric and magnetic fields have been induced using lasers [3][4][5]. Moreover, these setups may be extended to generate non-Abelian fields, and in particular, spin-orbit coupling [6][7][8][9][10][11][12][13]. Synthetic fields may be generated as well in optical lattices, and recent experiments have created artificial staggered [14][15][16] and uniform [17,18] magnetic fields. These fields are, however, static, as they are not influenced by the atoms.The dynamical feedback between matter and gauge fields plays an important role in various areas of physics, ranging from condensed matter [19] to quantum chromodynamics [20], and its realization in cold lattice gases is attracting growing attention [21]. Schemes have been recently proposed for multicomponent lattice gases, such that the low-energy description of these systems is that of relevant quantum field theories [22][23][24][25][26][27][28][29][30][31]. The backaction of the atoms on the value of a synthetic gauge field is expected to lead to interesting physics, including statistically induced phase transitions and anyons in 1D lattices [32], and chiral solitons in Bose-Einstein condensates [33].Periodically modulated optical lattices open interesting possibilities for the engineering of lattice gases [16][17][18][34][35][36][37][38][39][40]. In particular, periodic lattice shaking results in a modified hopping rate [34][35][36], which has been employed to drive the superfluid (SF) to Mott insulator (MI) transition [37], to simulate frustrated classical magnetism [38], and to create tunable gauge potentials [16]. Interestingly, a periodically modulated magnetic field may be employed in the vicinity of a Feshbach resonance to induce periodically modulated interactions, which result in a nonlinear hopping rate that depends on the occupation differences at neighboring sites [41][42][43].In this Letter, we show that combining periodic interactions and Raman-assisted hopping may induce a densitydependent gauge field in 1D lattices. The created field results in a density-dependent shift of the momentum distribution that may be probed in time-of-flight (TOF) experiments. Moreover, contrary to the Peierls phase induced in shaken lattices [16], the created field cannot be ga...