Ultradian and circadian body temperature and activity rhythms in chronic MPTP treated monkeys

Almirall, Helena; Mora-Bautista, Víctor Manuel; Sánchez-Bahillo, Ángel; Trinidad-Herrero, M

doi:10.1016/s0987-7053(01)00256-8

Cited by 30 publications

(29 citation statements)

References 13 publications

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“…Subcutaneous body temperature data are not identical to 'core' body temperature but are likely closely correlated in the macaque. For this study, mean temperature before challenge was about 11C lower than values reported for intraperitoneal temperature in Japanese (Takasu et al, 2002) and pigtail (MR Weed, personal communication) macaques; this was consistent with prior reports for subcutaneous temperature in cynomolgous (Almirall et al, 2001) and rhesus (Horn et al, 1998) macaques. The circadian patterns of temperature regulation appear highly similar between s.c. and i.p.…”

Section: Discussionsupporting

confidence: 91%

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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The ambient temperature (T A ) under which rodents are exposed to (7)3,4-methylenedioxymethamphetamine (MDMA) affects the direction and magnitude of the body temperature response, and the degree of hypo/hyperthermia generated in subjects can modify the severity of lasting brain changes in 'neurotoxicity' models. The thermoregulatory effects of MDMA have not been well described in nonhuman primates and it is unknown if T A has the potential to affect acute hyperthermia and therefore other lasting consequences of MDMA. The objective of this study was to determine if the temperature alteration produced by MDMA in nonhuman primates depends on T A as it does in rats and mice. Body temperature and spontaneous home cage activity were monitored continuously in six male rhesus monkeys via radiotelemetry. The subjects were challenged intramuscularly with 0.56-2.4 mg/kg (7)MDMA under each of three T A conditions (18, 24, and 301C) in a randomized order. The temperature was significantly elevated following injection with all doses of MDMA under each ambient temperature. The magnitude of mean temperature change was B11C in most conditions suggesting a closely controlled thermoregulatory response in monkeys across a range of doses and ambient temperatures. Activity levels were generally suppressed by MDMA; however, a 50% increase over vehicle was observed after 0.56 MDMA under the 301C condition. It is concluded that MDMA produces a similar degree of hyperthermia in rhesus monkeys across a range of T A conditions that result in hypothermia or exaggerated hyperthermia in rodents. Monkey temperature responses to MDMA appear to be more similar to humans than to rodents and therefore the monkey may offer an improved model of effects related to MDMA-induced hyperthermia.

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Section: Discussionsupporting

confidence: 91%

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Huben

Lay

Crean

et al. 2006

Neuropsychopharmacol

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“…The significant decrease in locomotor activity observed after MPTP administration (Fig. 4) was also in a similar range to that previously reported (Almirall et al, 1999(Almirall et al, , 2001Nakai et al, 1990).…”

Section: Discussionsupporting

confidence: 90%

“…The hours of high activity usually coincided in both groups (Figs. 2 and 3), similar results having been obtained for normal circadian activity in previous studies (Almirall et al, 1999(Almirall et al, , 2001Aureli et al, 1999;Bowers et al, 1998;Mehlman et al, 2000). The significant decrease in locomotor activity observed after MPTP administration (Fig.…”

Section: Discussionsupporting

confidence: 89%

Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity

Barcia

Pablos

Bautista-Hernández

et al. 2004

Journal of Neuroscience Methods

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“…These same two circadian rhythms reappeared after administration of levodopa. In yet another study, MPTP-treated monkeys exhibited decrease in the robustness of the circadian components of both body temperature and locomotor activity, with increasing motor impairment and fragmentation of the body temperature rhythm into 8-h-period components (Almirall et al, 2001). In spite of all these findings, to our knowledge no studies have been conducted so far examining the effects of rotenone on circadian rhythms.…”

Section: Introductionmentioning

confidence: 91%

Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model

Lax

Esquiva

Esteve-Rudd

et al. 2012

Chronobiology International

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Parkinson's disease (PD) is a neurodegenerative disorder that also involves circadian rhythm alterations. Modifications of circadian rhythm parameters have been shown to occur in both PD patients and toxin-induced PD animal models. In the latter case, rotenone, a potent inhibitor of mitochondrial complex I (nicotinamide adenine dinucleotide [NADH]-quinone reductase), has been used to elicit degeneration of dopaminergic neurons and development of parkinsonian syndrome. The present work addresses alterations induced by rotenone on both locomotor and body temperature circadian rhythms in rats. Rotenone-treated rats exhibited abnormalities in equilibrium, postural instability, and involuntary movements. Long-term subcutaneous administration of rotenone significantly reduced mean daily locomotor activity in most animals. During rotenone administration, mean body temperatures (BTs) and BT rhythm amplitudes were significantly lower than those observed in the control group. After long-term rotenone administration, the circadian rhythms of both locomotor activity (LA) and BT displayed decreased amplitudes, lower interdaily phase stability, and higher rhythm fragmentation, as compared to the control rats. The magnitude of the LA and BT circadian rhythm alterations induced by rotenone positively correlated with degree of motor impairment. These results indicate that rotenone induces circadian dysfunction in rats through some of the same mechanisms as those responsible for the development of motor disturbances.

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Ultradian and circadian body temperature and activity rhythms in chronic MPTP treated monkeys

Cited by 30 publications

References 13 publications

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Impact of Ambient Temperature on Hyperthermia Induced by (±)3,4-Methylenedioxymethamphetamine in Rhesus Macaques

Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity

Circadian Dysfunction in a Rotenone-Induced Parkinsonian Rodent Model

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