Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum

Yoshiura, Shigeki; Ohtsuka, Toshiyuki; Takenaka, Yasuhiro; Nagahara, Hiroki; Yoshikawa, Kenichi; Kageyama, Ryoichiro

doi:10.1073/pnas.0701837104

Cited by 125 publications

(146 citation statements)

References 30 publications

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“…Oscillations were also reported in some signaling pathways regulating Hes factors, such as Notch, Jak-Stat, and Fgf signalings (Kageyama, et al, 2010;Niwa et al, 2007;Yoshiura et al, 2007). For example, Notch and Fgf signaling cooperatively regulate Hes7 oscillation and achieve a spatiotemporal regulation during somite segmentation events (Niwa et al, 2011).…”

Section: Discussionmentioning

confidence: 97%

“…4B) (Yoshiura et al, 2007). Jak2 kinase activates Stat3 by phosphorylation, and activated Stat3 induces the expression of downstream genes, including Socs3, an inhibitor of Jak2 kinase.…”

Section: Hes1 Oscillation and Cell Proliferation In Cultured Cellsmentioning

confidence: 99%

“…Sustained Hes1 expression leads to G1 phase retardation of the cell cycle (Yoshiura et al, 2007). Hes1 can directly or indirectly repress the transcription of cell cycle-related genes, including E2f1, p21Cip1, p27Kip1, and p57Kip2 (Castella, et al, 2000;Georgia, et al, 2006;Hartman et al, 2004;Murata et al, 2005).…”

Section: Hes1 Oscillation and Cell Proliferation In Cultured Cellsmentioning

confidence: 99%

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Expression Dynamics and Functions of Hes Factors in Development and Diseases

Kobayashi

Kageyama

2014

Current Topics in Developmental Biology

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Hes genes, encoding basic helix-loop-helix (HLH) transcriptional repressors, are mammalian homologues of Drosophila hairy and Enhancer of split genes, both of which are required for normal neurogenesis in Drosophila. There are seven members in the human Hes family, Hes1 to Hes7, which are expressed in many tissues and play various roles mainly in development. All Hes proteins have three conserved domains: basic HLH (bHLH), Orange, and WRPW domains. The basic region binds to target DNA sequences while the HLH region forms homo-and hetero-dimers with other bHLH proteins, the Orange domain is responsible for the selection of partners during heterodimer formation, and the WRPW domain recruits co-repressors. Hes1, Hes5, and Hes7 are known as downstream effectors of canonical Notch signaling, which regulates cell differentiation via cell-cell interaction. Hes factors regulate many events in development by repressing the expression of target genes, many of which encode transcriptional activators that promote cell differentiation. For example, Hes1, Hes3, and Hes5 are highly expressed by neural stem cells, and inactivation of these genes results in insufficient maintenance of stem cell proliferation and prematurely promotes neuronal differentiation. Recently, it was shown that the expression dynamics of Hes1 plays crucial roles in proper developmental timings and fate determination steps of embryonic stem cells and neural progenitor cells. Here we discuss some key features of Hes factors in development and diseases.

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Section: Discussionmentioning

confidence: 97%

“…4B) (Yoshiura et al, 2007). Jak2 kinase activates Stat3 by phosphorylation, and activated Stat3 induces the expression of downstream genes, including Socs3, an inhibitor of Jak2 kinase.…”

Section: Hes1 Oscillation and Cell Proliferation In Cultured Cellsmentioning

confidence: 99%

Section: Hes1 Oscillation and Cell Proliferation In Cultured Cellsmentioning

confidence: 99%

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Expression Dynamics and Functions of Hes Factors in Development and Diseases

Kobayashi

Kageyama

2014

Current Topics in Developmental Biology

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“…After serum stimulation or Notch activation, Hes1 expression oscillates with a periodicity of about 2 hours in many cell types, suggesting that Hes1 may regulate many biological processes as a biological clock with a 2-hour cycle (Hirata et al 2002). Both sustained Hes1 expression and knock down of Hes1 activity reduce proliferation of fibroblasts, suggesting that oscillatory Hes1 expression is required for efficient proliferation of fibroblasts (Yoshiura et al 2007). Furthermore, persistent Hes1 expression also inhibits proliferation and differentiation of neuroblasts (Baek et al 2006).…”

Section: Hes1 Oscillation In Non-psm Cellsmentioning

confidence: 99%

“…To identify new ultradian oscillators, RNA was prepared from fibroblasts every 30 minutes after serum stimulation and subjected to microarray analyses, which revealed oscillatory responses of Socs3 and Smad6 (Yoshiura et al 2007). Expression of both genes oscillates with a period of about 2 hours, although the peaks appear at different times.…”

Section: Other Ultradian Oscillatorsmentioning

confidence: 99%

Ultradian Oscillators in Somite Segmentation and Other Biological Events

Kageyama¹,

Yoshiura²,

Masamizu³

et al. 2007

Cold Spring Harbor Symposia on Quantitative Biology

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RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells

Sfeir,

Kajdan,

Jalaguier

et al. 2024

Molecular Oncology

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The transcription factor receptor‐interacting protein 140 (RIP140) regulates intestinal homeostasis and tumorigenesis through Wnt signaling. In this study, we investigated its effect on the Notch/HES1 signaling pathway. In colorectal cancer (CRC) cell lines, RIP140 positively regulated HES1 gene expression at the transcriptional level via a recombining binding protein suppressor of hairless (RBPJ)/neurogenic locus notch homolog protein 1 (NICD)‐mediated mechanism. In support of these in vitro data, RIP140 and HES1 expression significantly correlated in mouse intestine and in a cohort of CRC samples, thus supporting the positive regulation of HES1 gene expression by RIP140. Interestingly, when the Notch pathway is fully activated, RIP140 exerted a strong inhibition of HES1 gene transcription controlled by the level of HES1 itself. Moreover, RIP140 directly interacts with HES1 and reversed its mitogenic activity in human CRC cells. In line with this observation, HES1 levels were associated with a better patient survival only when tumors expressed high levels of RIP140. Our data identify RIP140 as a key regulator of the Notch/HES1 signaling pathway, with a dual effect on HES1 gene expression at the transcriptional level and a strong impact on colon cancer cell proliferation.

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Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum

Cited by 125 publications

References 30 publications

Expression Dynamics and Functions of Hes Factors in Development and Diseases

Expression Dynamics and Functions of Hes Factors in Development and Diseases

Ultradian Oscillators in Somite Segmentation and Other Biological Events

RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells

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