2024
DOI: 10.1038/s41598-024-59567-6
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Ultrafast and efficient continuous flow organic synthesis with a modified extruder-grinder system

Omid Hosseinchi Qareaghaj,
Mohammad Ghaffarzadeh,
Najmedin Azizi

Abstract: The study introduces a groundbreaking continuous system that combines an extruder and grinder to enable catalyst-free and solvent-free reactions under mild conditions. This temperature-controlled system facilitates the synthesis of highly functionalized chromenes, which have valuable applications in generating combinatorial libraries and complex target molecules. The newly developed mill extruder machine offers several advantages for industrial production on a large scale. It effectively reduces waste, saves e… Show more

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