Ultrafine Nanoparticles of Ibuprofen-Poly(methyl methacrylate) by a Polymerization-Loading Method

Saade, Hened; Barrera, Cynthia; Espinoza, Alejandro; Lopez‐Quintanilla, M. L.; Fernández, Salvador; López, Raúl G.

doi:10.2174/2210304x11303010008

Cited by 7 publications

(5 citation statements)

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“…In turn, this slows down particle growth, leading to a large number of smaller particles in accordance with 2 International Journal of Polymer Science the emulsion polymerization theory [15,16]. A more detailed explanation of this effect has already been reported elsewhere by our group [17,18].…”

Section: Introductionsupporting

confidence: 79%

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Balleño

Mendizabal-Ruiz

Saade³

et al. 2018

International Journal of Polymer Science

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Ibuprofen-loaded poly(ethyl cyanoacrylate) nanoparticles were prepared by semicontinuous heterophase polymerization of ethyl cyanoacrylate in the presence of ibuprofen; different surfactant concentration, pH, and temperature were used. Particle size was measured by quasi-light scattering and transmission electron microscopy, while the amount of drug released was determined by UV spectroscopy. Nanoparticles with diameters between 10 and 58 nm, loaded with ibuprofen, were obtained. The smallest particles and the higher drug loading were obtained at the highest pH tested. The analysis of the release data showed that the drug release profiles correspond to the Weibull model. Moreover, it was found that most of the ibuprofen is released within the first 80-120 min; initially the release rate is slow, but then it increases to finally decrease. This behavior contrasts with the reported burst of drug concentration in the plasma after oral administration of IB.

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Section: Introductionsupporting

confidence: 79%

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Balleño

Mendizabal-Ruiz

Saade³

et al. 2018

International Journal of Polymer Science

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“…Using SHP can help to prepare PNs that contain CNTs to be chemically attached to an acrylate monomer [ 36 ]. Moreover, it has been shown that suitable polymers can be prepared to deliver drugs by SHP [ 37 ]. It is notable to mention that due to alkyl methacrylate type polymers, prepared by SHP under monomer-starved condition can develop tacticity [ 38 ], it could be possible that this technique would induce favorable conditions to synthesize more ordered polymer chains, which favors a homogeneous CNTs dispersion into a methacrylic polymer used as a polymer matrix of a PN.…”

Section: Introductionmentioning

confidence: 99%

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

et al. 2022

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The design of nanocomposites with the potential for drug delivery is a topic of great interest. In this work, the synthesis of nanocomposites of poly(methacrylic acid) (PMAA) grafted onto carbon nanotubes (CNTs) functionalized with poly(amidoamine) (PAMAM) dendrimer by semicontinuous heterophase polymerization SHP, at three different methacrylic acid (MAA) dosing rates, is reported. SHP is a polymerization technique poorly used to prepare nanocomposites containing CNTs and has the potential to produce more ordered alkyl methacrylic polymer chains, which could favor the obtaining of a homogenous nanocomposite. For the nanocomposites synthesized, a lowest addition rate monomer-starved condition was reached. Analysis by X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA) demonstrate that functionalized CNTs are grafted onto the PMAA matrix. The ability of prepared nanocomposites to deliver hydrocortisone was evaluated by ultraviolet-visible spectroscopy (UV-Vis). The hydrocortisone release profiles of pure PMAA and of their nanocomposites prepared at the lowest monomer fed rate were fitted with Higuchi and Korsmeyer–Peppas models, successfully. Functionalized CNTs have a crucial role to induce an effective release of hydrocortisone from the prepared nanocomposites.

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“…Moreover, chitosan, pectin, alginate, poly( ε -caprolactone), poly(methyl methacrylate), poly(lactic acid) can be used as matrices for DDSs due to biocompatibility and easy handle. 24–29…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, chitosan, pectin, alginate, poly(εcaprolactone), poly(methyl methacrylate), poly(lactic acid) can be used as matrices for DDSs due to biocompatibility and easy handle. [24][25][26][27][28][29] Nowadays, natural rubber latex (NRL) membranes have been used as matrix due to their angiogenic activity and debridement potential, besides being biocompatible and effective for wound healing. This biopolymer is extracted from the rubber tree Hevea brasiliensis and contains 45% weight of dry rubber (cis-1,4-polyisoprene), 50% of water and 5% of proteins, carbohydrates, lipids and other non-rubber materials.…”

Section: Introductionmentioning

confidence: 99%

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Lima

Pegorin

Miranda

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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The incorporation of drugs and bioactive compounds in the natural rubber latex (NRL) matrix has been an alternative for the development of transdermal release membranes. Ibuprofen (IBF) is known to be used to treat inflammatory diseases, but when administered orally, high concentrations can cause some adverse problems. In this work, the incorporation of IBF in the NRL membranes was evaluated by physical-chemical, in vitro permeation, hemocompatibility and molecular modeling assays. In addition, the in vitro release profile of IBF in acid and basic media was analyzed during 96 h. The IBF-NRL membrane exhibited the absence of intermolecular bonding that could hinder drug release and presented compatible mechanical properties for applications as a cutaneous adhesive (0.58 and 1.12 MPa to Young’s modulus and rupture tension, respectively). The IBF-NRL system did not present a significant hemolysis degree (1.67%) within 24 h. The release test indicated that in the first hours of the study, 48.5% IBF was released at basic pH and 22.5% at acidic pH, which is characteristic of a burst effect. Then, a stable release profile was observed until the end of the assay, with total IBF release of 60% in alkaline medium and 50% in acidic medium. The drug permeation results indicated that the IBF-NRL membranes can be used for the local skin treatment with permeation of 3.11% of IBF. Dynamic Molecular simulations indicated a pronounced electric dipole in the ionized form of IBF, which suggests a more effective interaction with water, explaining the efficient drug release in alkaline solutions. In general, the results demonstrate that the IBF-NRL membrane has great potential for a new adhesive that can be used for the treatment of inflammatory processes and injuries.

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Ultrafine Nanoparticles of Ibuprofen-Poly(methyl methacrylate) by a Polymerization-Loading Method

Cited by 7 publications

References 0 publications

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Ibuprofen Release from Poly(ethyl cyanoacrylate) Nanoparticles Prepared by Semicontinuous Heterophase Polymerization

Semi-Continuous Heterophase Polymerization to Synthesize Poly(methacrylic acid)-Based Nanocomposites for Drug Delivery

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

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