Ultrafine Particles in Airways: A Novel Marker of Inflammation and Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Risk

Klein, Einat Fireman; Adir, Yochai; Krencel, Amir; Fireman, Elizabeth; Peri, Regina; Kessel, Aharon

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4050

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EBC examination is a non-invasive and safe method of collecting airway lining fluid to observe the pulmonary environment (Seifi et al 2021 ; Pirozzi et al 2015 ), and is used to evaluate pulmonary inflammation. It is a promising method to reflect the levels of inflammatory biomarkers (such as IL-1β, IL-6, and IL-8) and identify respiratory or pulmonary diseases (Kharitonov et al 2001; Montuschi et al 2002; Fireman et al 2019 ). In the current study, EBC was collected to analyze the levels of inflammatory cytokines, including IL-1β, IL-6, IL-8, IL-17A, and MCP-1.…”

Section: Methodsmentioning

confidence: 99%

“…EBC, a non-invasive method of collecting airway lining fluid, is a simple way to observe the pulmonary environment (Pirozzi et al 2015 ). It is a promising method to reflect the levels of inflammatory biomarkers and monocyte chemoattractant protein (MCP)-1 and to identify respiratory or pulmonary-related diseases (Kharitonov and Barnes 2001 ; Montuschi and Barnes 2002 ; Fireman et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exposure to incense burning, biomarkers, and the physical health of temple workers in Taiwan

Guo,

Ratner,

Tseng

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Incense burning releases heavy particulate matter (PM) and nitrogen dioxide (NO2), known to have adverse effects on human health. Long-term exposure to PM and NO2 increases inflammatory cytokine levels and can induce respiratory diseases. This study examined the association between incense burning exposure and the health status, especially inflammatory biomarkers, of temple workers and volunteers in Taiwan. The longitudinal observational study compared adult temple workers and volunteers, with long-term incense burning exposure, to residents from outpatient clinics in the Chiayi area. Forced expiratory volume in 1 s (FEV1) and serum and exhaled breath condensate (EBC) cytokines were assessed. Nonparametric Mann-Whitney U tests were used to compare cytokine levels of the exposure and control groups during the cold and hot weather seasons. FEV1 was significantly more diminished in the exposed group than in the control group during the cold season. Exposure status was associated with greater hot-cold seasonal differences in serum interleukins (IL)-1β (regression coefficient (B) = 6.6, 95% confidence interval (CI) = 5.0 to 8.3, p < .001), IL17-A (B = 2.4, 95% CI = 0.3 to 4.5, p = .03), and plasminogen activator inhibitor [PAI]-1 (B = 5.4, 95% CI = 1.5 to 9.3, p = .009). After adjusting for confounders, the groups’ serum levels of IL-1β, IL-17A, and PAI-1 significantly differed. EBC cytokines did not show significant differences. Elevated levels of IL-1β, IL17-A, and PAI-1 have been associated with various autoinflammatory syndromes and diseases. Given the cultural significance of incense burning, culturally sensitive interventions, including education, policy development, and program implementation, are crucial to protect individuals’ health, especially temple workers, from the adverse effects of exposure, addressing the manufacture, importation, and sale of incense.

show abstract

Section: Methodsmentioning

confidence: 99%