Ultrahigh‐frequency ultrasound of fascicles in the median nerve at the wrist

Cartwright, Michael S.; Baute, Vanessa; Caress, James B.; Walker, Francis O.

doi:10.1002/mus.25617

Cited by 57 publications

(57 citation statements)

References 8 publications

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“…In agreement with their findings, the present study has demonstrated the feasibility of UHF ultrasound for visualizing single nerve fascicles in young children with SMA. The counted fascicle numbers of controls in our study were similar to previous descriptions in adults using UHF, histology, or magnetic resonance imaging protocols . Although the mean area of the nerves was about half of that reported in adults, our findings are in line with previous reports of cross‐sectional areas assessed by high‐resolution ultrasonography in children …”

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounsupporting

confidence: 92%

“…Previously, Cartwright et al showed the general feasibility and good interreader reliability of counting fascicles of the median nerve using UHF ultrasound, suggesting the potential of UHF ultrasound as a diagnostic tool or imaging biomarker in several neurological disorders in adults . In agreement with their findings, the present study has demonstrated the feasibility of UHF ultrasound for visualizing single nerve fascicles in young children with SMA.…”

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounsupporting

confidence: 90%

“…Using the contralateral median nerve as an internal control, we found no side differences for fascicle numbers within each participant. Notably, fascicle numbers in the SMA type II patient were similar on both sides, being unaffected by a median artery that was reported to potentially influence both the fascicle count and nerve size/area . The nerve area, however, was smaller on the side where the artery was present (4.420 mm 2 vs 5.976 mm 2 ).…”

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 79%

“…Ultrasound imaging is well recognized in neuromuscular disorders (NMDs) and holds promise as a diagnostic modality for personalized medicine in rare diseases . Ultra–high‐frequency (UHF) ultrasound enables high‐resolution visualization of peripheral nerves, permitting detection of single nerve fascicles in the median nerves of healthy adults . To investigate the feasibility of UHF ultrasound to display nerve structures in children with NMD, we conducted a retrospective analysis of pediatric patients who presented to our neuropediatric department between May 13 and May 21, 2019.…”

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 99%

“…The latter were used for further blinded analysis with an open‐source DICOM viewer (Horos version 3.3.5; Nimble Co LLC d/b/a Purview, Annapolis, Maryland). According to Cartwright et al, a cross‐sectional area was drawn within the hyperechoic epineurium and outside of the nerve fascicles. The number of fascicles was counted within the median nerve and fascicle density (number of fascicles/mm 2 ) was calculated.…”

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 99%

See 4 more Smart Citations

Ultra–high‐frequency ultrasound in patients with spinal muscular atrophy: A retrospective feasibility study

et al. 2020

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Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounsupporting

confidence: 92%

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounsupporting

confidence: 90%

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 79%

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 99%

Section: Patients' Characteristics and Ultra–high‐frequency Ultrasounmentioning

confidence: 99%

See 3 more Smart Citations

Ultra–high‐frequency ultrasound in patients with spinal muscular atrophy: A retrospective feasibility study

et al. 2020

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Bifid median nerve as an anatomical risk factor for carpal tunnel syndrome: A meta‐analysis

et al. 2022

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As the median nerve enters the carpal tunnel, it is a single nerve that soon bifurcates into lateral and medial branches into the hand. If the bifurcation is proximal to the carpel tunnel, a bifid median nerve (BMN) results. Carpal tunnel syndrome is often associated with a BMN with or without a persistent median artery. Individual keywords and MeSH phrases were searched in the Google Scholar, SCOPUS, and PubMed databases. Full texts were then collected and assessed for suitability. The prevalence of BMN at the wrist joint in normal and carpal tunnel syndrome wrists (precanal part) and the mean difference between groups were recorded. Only human data were used to test the findings. The pooled odds ratio (with minimal heterogeneity) was 1.50 [1.17–1.93, 95% CI]. The BMN cross‐sectional area (CSA) was significantly greater than that of a solitary median nerve in normal wrists. The mean difference in CSA between the two was 1.50 mm2 [0.56–2.45 mm2, 95% CI] without heterogeneity (i2 = 0). Sex and laterality distributions scarcely differed between the two types of wrists. Owing to the insufficiency of data, the relationships with mean height and weight were not examined. There was a 50% greater incidence of bifid median nerves in carpal tunnel syndrome patients than in normal subjects. A bifid median nerve increases the mean CSA at the wrist joint by 1.5 mm2. These findings indicate that the bifid median nerve is an anatomical risk factor for carpal tunnel syndrome.

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The Role of 70‐MHz Ultrahigh‐Frequency Ultrasound in the Peripheral Nerve Injury

Marco,

Nicola,

Claudio

et al. 2024

J of Clinical Ultrasound

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AimHigh‐frequency ultrasound with an 18‐MHz probe (18 MHz‐HFUS) plays a relevant role in the evaluation of peripheral nerve injury (PNI). Ultrahigh‐frequency ultrasound with a 70‐MHz probe (70 MHz‐UHFUS) offers higher spatial resolution and could allow a better detection of PNI. This study aimed to compare the diagnostic performance of HFUS and UHFUS in PNI detection.Materials and MethodsIn this retrospective study, were selected, between July 2022 and April 2024, 61 patients underwent HFUS, UHFUS, and nerve conduction study (NCS) for clinical suspicion of traumatic forearm PNI. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of HFUS and UHFUS in PNI detection were calculated and compared. NCS was used as the reference standard. Nonparametric statistical tests were used. A p value of < 0.05 was considered statistically significant.ResultsComparing the diagnostic performance in PNI detection, the 70 MHz‐UHFUS showed a sensitivity and diagnostic accuracy significantly higher than 18 MHz‐HFUS, respectively, 98.0% versus 82.4% (p = 0.0205) and 95.1% versus 82.0% (p = 0.0468). Otherwise, not significantly difference were in specificity, PPV, and NPV.ConclusionsUHFUS compared to HFUS demonstrated a higher sensitivity and diagnostic accuracy in PNI detection.

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Ultrahigh‐frequency ultrasound of fascicles in the median nerve at the wrist

Abstract: Fascicles within the median nerve at the wrist can be readily imaged. Ultrahigh-frequency ultrasound technology may be informative in a variety of disorders affecting the peripheral nervous system. Muscle Nerve 56: 819-822, 2017.

Cited by 57 publications

References 8 publications

Ultra–high‐frequency ultrasound in patients with spinal muscular atrophy: A retrospective feasibility study

Ultra–high‐frequency ultrasound in patients with spinal muscular atrophy: A retrospective feasibility study

Bifid median nerve as an anatomical risk factor for carpal tunnel syndrome: A meta‐analysis

The Role of 70‐MHz Ultrahigh‐Frequency Ultrasound in the Peripheral Nerve Injury

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