Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source

Ko, Tony H.; Adler, Desmond C.; Fujimoto, James G.; Mamedov, D S; Prokhorov, Viatcheslav V.; Shidlovski, Vladimir R.; Yakubovich, S D

doi:10.1364/opex.12.002112

Cited by 128 publications

(60 citation statements)

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“…Broad-bandwidth superluminescent diode light sources, similar to the one used in this study, recently have been shown to enable UHR OCT image resolution performance approaching that of femtosecond lasers. [27][28][29][30][31][32][33][34][35][36][37][38] Our research prototype high-speed UHR OCT system has been described in detail in previous publications. [29][30][31][32][33] This system can acquire up to 25 000 axial scans per second, corresponding to ~49 images (512 axial scans per image) per second.…”

Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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Objective-To assess high-speed ultrahigh-resolution optical coherence tomography (OCT) image resolution, acquisition speed, image quality, and retinal coverage for the visualization of macular pathologies. Design-Retrospective cross-sectional study.Participants-Five hundred eighty-eight eyes of 327 patients with various macular pathologies.Methods-High-speed ultrahigh-resolution OCT images were obtained in 588 eyes of 327 patients with selected macular diseases. Ultrahigh-resolution OCT using Fourier/spectral domain detection achieves ~3-μm axial image resolutions, acquisition speeds of ~25 000 axial scans per second, and >3 times finer resolution and >50 times higher speed than standard OCT. Three scan protocols were investigated. The first acquires a small number of high-definition images through the fovea. The second acquires a raster series of high-transverse pixel density images. The third acquires 3-dimensional OCT data using a dense raster pattern. Three-dimensional OCT can generate OCT fundus images that enable precise registration of OCT images with the fundus. Using the OCT fundus images, OCT results were correlated with standard ophthalmoscopic examination techniques. Main Outcome Measures-High-definition macular pathologies.Results-Macular holes, age-related macular degeneration, epiretinal membranes, diabetic retinopathy, retinal dystrophies, central serous chorioretinopathy, and other pathologies were imaged and correlated with ophthalmic examination, standard OCT, fundus photography, and fluorescein angiography, where applicable. High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT. The speed preserves retinal topography, thus enabling the visualization of subtle changes associated with disease. High-definition high-transverse pixel density Conclusions-High-definition 3-dimensional imaging using high-speed ultrahigh-resolution OCT improves image quality, retinal coverage, and registration. This new technology has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.Optical coherence tomography (OCT) is a medical imaging technology that can perform highresolution cross-sectional imaging of tissue morphology in situ and in real time. Optical coherence tomography imaging is analogous to ultrasound, except that it uses light rather than sound and measures the echo time delay and magnitude of reflected or backscattered light using low-coherence interferometry. Cross-sectional images are generated by directing an optical beam onto tissue and scanning it in the transverse direction, thus yielding a data set that can be displayed as false-color or grayscale images. Despite the successful clinical application of OCT technology, there are several limitations. Without using techniques such as eye tracking, the total permissible image acquisition time is limited by subject eye motion, which can cause imag...

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Section: Methodsmentioning

confidence: 99%

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

et al. 2006

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“…Though this resolution is sufficient to image retinal layers, identification of individual cells or sub-cellular structures is not possible. Pushing towards cellular imaging, advanced SLDs have been developed with wide spectral bandwidths ≥ 80 nm by multiplexing 2 or more SLDs, providing OCT axial resolutions of < 10 m Cense et al, 2009a;Hong et al, 2007;Ko et al, 2004;Potsaid et al, 2008;Zawadzki et al, 2005). A prototype of this ultrawideband SLD for OCT imaging was first demonstrated by Ko et al in 2004.…”

Section: Sld Sourcesmentioning

confidence: 99%

“…Pushing towards cellular imaging, advanced SLDs have been developed with wide spectral bandwidths ≥ 80 nm by multiplexing 2 or more SLDs, providing OCT axial resolutions of < 10 m Cense et al, 2009a;Hong et al, 2007;Ko et al, 2004;Potsaid et al, 2008;Zawadzki et al, 2005). A prototype of this ultrawideband SLD for OCT imaging was first demonstrated by Ko et al in 2004. Two independent SLD sources at center wavelengths 840 and 920 nm were combined with a custom designed fiber coupler based on fiber GRIN microlenses and miniature dielectric coated mirrors Ko et al, 2004).…”

Section: Sld Sourcesmentioning

confidence: 99%

“…A prototype of this ultrawideband SLD for OCT imaging was first demonstrated by Ko et al in 2004. Two independent SLD sources at center wavelengths 840 and 920 nm were combined with a custom designed fiber coupler based on fiber GRIN microlenses and miniature dielectric coated mirrors Ko et al, 2004). OCT imaging in the retina with this SLD, which had a 155 nm bandwidth, resulted in axial resolutions of ~ 3.2 µm.…”

Section: Sld Sourcesmentioning

confidence: 99%

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Cellular Level Imaging of the Retina Using Optical Coherence Tomography

Greiner¹,

Choi²

2012

Selected Topics in Optical Coherence Tomography

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“…A broadband light source is often desirable for ultrahigh axial resolution in OCT because this resolution ISSN: 1226-4776(Print) / ISSN: 2093-6885(Online) DOI: http://dx.doi.org/10.3807/JOSK.2015. 19.1.055 is inversely proportional to the FWHM of the light source [6][7][8][9][10][11]. Drexler et al first introduced UHR-OCT using an ultrashort-pulse (< 10 fs) Ti:sapphire laser with a FHWM of 260 nm at 800 nm, and obtained an OCT image of an African frog tadpole with 1-μm axial resolution [6].…”

Section: Introductionmentioning

confidence: 99%

Ultrahigh-Resolution Spectral Domain Optical Coherence Tomography Based on a Linear-Wavenumber Spectrometer

Lee

Kang

Park

et al. 2015

Journal of the Optical Society of Korea

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In this study we demonstrate ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) with a linear-wavenumber (k) spectrometer, to accelerate signal processing and to display two-dimensional (2-D) images in real time. First, we performed a numerical simulation to find the optimal parameters for the linear-k spectrometer to achieve ultrahigh axial resolution, such as the number of grooves in a grating, the material for a dispersive prism, and the rotational angle between the grating and the dispersive prism. We found that a grating with 1200 grooves and an F2 equilateral prism at a rotational angle of 26.07°, in combination with a lens of focal length 85.1 mm, are suitable for UHR SD-OCT with the imaging depth range (limited by spectrometer resolution) set at 2.0 mm. As guided by the simulation results, we constructed the linear-k spectrometer needed to implement a UHR SD-OCT. The actual imaging depth range was measured to be approximately 2.1 mm, and axial resolution of 3.8 μm in air was achieved, corresponding to 2.8 μm in tissue (n = 1.35). The sensitivity was -91 dB with -10 dB roll-off at 1.5 mm depth. We demonstrated a 128.2 fps acquisition rate for OCT images with 800 lines/frame, by taking advantage of NVIDIA's compute unified device architecture (CUDA) technology, which allowed for real-time signal processing compatible with the speed of the spectrometer's data acquisition.

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Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source

Cited by 128 publications

References 20 publications

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography

Cellular Level Imaging of the Retina Using Optical Coherence Tomography

Ultrahigh-Resolution Spectral Domain Optical Coherence Tomography Based on a Linear-Wavenumber Spectrometer

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