Ultrahigh-sensitivity multi-parameter tacrolimus solution detection based on an anchor planar millifluidic microwave biosensor

Yang, Xiaojun; Chen, Guo; Zhang, Mengqi; Li, Yuanyue; Ren, Mengna; Sui, Mao; Dhakal, Rajendra; Kim, Nam‐Young; Dong, Zhen; Sun, Bin; Yao, Zhao

doi:10.1039/d3ay00100h

Cited by 3 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Technique Matrix LOD (ng/mL) Dynamic range (ng/mL) Ref. Coupling of solid-phase microextraction to mass spectrometry Whole blood 0.3 1–50 [ 47 ] UHPLC Pharmaceutical Formulation – 1.0 × 10 5 –3.0 × 10 5 [ 15 ] LC/MS Plasma 0.01 0.01–2 [ 11 ] LC-MS/MS Whole blood – 1–40 [ 12 ] LC-MS/MS Whole blood – 0.5–60 [ 13 ] UPLC-MS/MS Whole blood – 50–5000 [ 16 ] HPLC-MS/MS Whole blood – 2.25–42.9 [ 50 ] Millifluidic microwave Whole blood 0.00012 10–500 [ 51 ] Microwave Blood 0.032 – [ 52 ] Immunoassay Blood ...…”

Section: Resultsmentioning

confidence: 99%

In-situ preparation of norepinephrine-functionalized silver nanoparticles and application for colorimetric detection of tacrolimus in plasma samples

Golsanamlu

Soleymani

Gharekhani

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

In-situ preparation of norepinephrine-functionalized silver nanoparticles and application for colorimetric detection of tacrolimus in plasma samples

Golsanamlu

Soleymani

Gharekhani

et al. 2023

Heliyon

View full text Add to dashboard Cite

Detection of carcinoembryonic antigen specificity using microwave biosensor with machine learning

Lei,

Zhang,

Wang

et al. 2025

Biosensors and Bioelectronics

View full text Add to dashboard Cite

Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods, Cytochrome P450 Enzymes after Heart Transplantation

Tolou-Ghamari

2024

CHAMC

View full text Add to dashboard Cite

Background: Advances in organ transplantation were made after the discovery of the pure form of cyclosporine by Dr Jean Borel in the 1970s. In fact, in clinical practice achieving a delicate balance in circulating immunosuppressive necessitate focus on the difficult task of post-transplant therapeutic drug monitoring. Objective: The purpose of this study was to determine the pharmacologic properties of cyclosporine-tacrolimus, detection methods, and the effects on the activity of cytochrome P450 enzymes when prescribing the most efficient treatments in forms of polypharmacy for the recipients of heart transplantation. Methods: Scientific literature on the interactions of tacrolimus and cyclosporine with human cytochrome P450 enzymes was searched using PUBMED.Gov (https://pubmed.ncbi.nlm.nih.gov/), Web of Science, and Scopus. Results: Prescription immunosuppressive drugs based on polypharmacy accompanied by induction agents could result in hidden neurotoxicity and nephrotoxicity. A literature search shows that cyclosporine prescription with antihypertensives drugs needs close monitoring. Co-administration of tacrolimus and diltiazem or verapamil needs a decrease in the tacrolimus dose by 20-50%. Vigilant attention to the lowest possible statin dose is needed when coadministered with fluvastatin or pravastatin. Polypharmacy based on ticlopidine, clopidogrel, and cyclosporine or tacrolimus needs monitoring of immunosuppressive drug levels for several months. A prescription with clotrimazole or fluconazole needs close monitoring, and itraconazole or ketoconazole needs to reduce the initial dose by 50%. Combination with nefazodone needs to be avoided, and alternative drugs such as sertraline or citalopram could be prescribed in addition to further monitoring consideration. In prescription with phenytoin, the bound and free phenytoin levels need close monitoring. Conclusion: Polypharmacy based on tacrolimus or cyclosporine needs vigilant therapeutic drug monitoring due to the cytochrome P450 enzymes associated with biochemical variables in metabolic pathways. Further attention to polypharmacy should be given to circulate drugs that could hide pharmacokinetics interactions associated with infections, malignancies, chronic kidney disease, and rejection after organ transplantation.

show abstract

Ultrahigh-sensitivity multi-parameter tacrolimus solution detection based on an anchor planar millifluidic microwave biosensor

Abstract: To detect drug concentration in tacrolimus solution, an anchor planar millifluidic microwave (APMM) biosensor is proposed. The millifluidic system integrated with the sensor enables accurate and efficient detection while eliminating...

Cited by 3 publications

References 45 publications

In-situ preparation of norepinephrine-functionalized silver nanoparticles and application for colorimetric detection of tacrolimus in plasma samples

In-situ preparation of norepinephrine-functionalized silver nanoparticles and application for colorimetric detection of tacrolimus in plasma samples

Detection of carcinoembryonic antigen specificity using microwave biosensor with machine learning

Tacrolimus and Cyclosporin Pharmacotherapy, Detection Methods, Cytochrome P450 Enzymes after Heart Transplantation

Contact Info

Product

Resources

About