Ultralong administration of gonadotropin-releasing hormone agonists before in vitro fertilization improves fertilization rate but not clinical pregnancy rate in women with mild endometriosis: a prospective, randomized, controlled trial

Effectiveness of ultra‐long protocol on in vitro fertilization/intracytoplasmic sperm injection‐embryo transfer outcome in infertile women with endometriosis: A systematic review and meta‐analysis of randomized controlled trials

“…Compared with the previous meta‐analysis published in 2020, [ 13 ] our meta‐analysis included two more RCT studies. [ 20,24 ] Our study showed that the efficacy of ultra‐long protocol is not different between early and advanced stage of endometriosis. There was an improvement in clinical pregnancy rate in the meta‐analysis reported in 2020 between ultra‐long protocol and long protocol in patients with stages III–IV endometriosis ( P < 0.05), while no statistically significant difference was found in our meta‐analysis ( P = 0.17).…”

“…The full texts of 64 remaining articles were reviewed for inclusion, and finally 9 RCTs were considered eligible for systematic review and meta‐analysis. [ 11,17–24 ] Details of the study selection process are shown in Figure 1.…”

“…Some studies do not meet the subgroup analysis conditions or do not clearly declare the staging of the disease, only few studies are included in the subgroup analysis of different stages. In early stage subgroup, two included studies [ 11,24 ] showed no significantly difference. But in advanced stage group, one study [ 19 ] showed significantly difference while another study [ 20 ] showed no significantly difference.…”

Effects of artificial cycles with and without gonadotropin-releasing hormone agonist pretreatment on frozen embryo transfer outcomes in patients with adenomyosis

“…Although many studies thought that administrating GnRH agonists was very bene cial for patients of adenomyosis in improving reproductive outcomes of IVF-ET, our study did not demonstrate advantages of adding GnRH agonists based on hormone replacement therapy cycle. Similiar negative conclusions were also shown in endometriosis [10][11][12]. In addition, Movahedi S et al did a study that Endometrial preparation for FET using GnRH agonists appeared to be as effective as FET without administrating these agonists [26].…”

“…In assisted reproductive technology(ART), GnRH-a had been widely used in patients with endometriosis for frozen or fresh embryo transfer in order to improve the pregnancy outcomes [6][7][8][9]. Another study found only fertilization rates but not clinical pregnancy rates involving fresh and frozen embryo transfer(FET) bene ted from GnRH-a for women with endometriosis [10]. There were also two studies which suggested GnRH-a down-regulation did not work well in patients of endometriosis undergoing IVF [11][12].…”