Ultramassive transfusion: give blood, save a life

Frank, Steven M.; Johnson, Daniel J.; Resar, Linda M.S.

doi:10.1111/trf.13403

Cited by 3 publications

(3 citation statements)

References 25 publications

(26 reference statements)

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“…Moreover, we need to know what threshold of each marker (or integrated/composite marker group) should be used to drive RBC transfusion in PICU patients, and what Hb concentration — possibly, in combination with marker response(s) — should be targeted after the RBC transfusion. Studies on transfusion-related complications in PICU patients are also required in order that practitioners can estimate the risk/benefit of giving or deferring a RBC transfusion in each patient; then, it will be possible to prescribe “the right dose of the right product, to the right patient for the right reason at the right time”, which would be the best possible “patient blood management” (111, 112).…”

Section: Discussionmentioning

confidence: 99%

Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

Doctor

Cholette

Remy

et al. 2018

Pediatric Critical Care Medicine

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Transfusion and Anemia Expertise Initiative developed pediatric-specific good practice statements and recommendations regarding RBC transfusion management in the general PICU population, as well as recommendations to guide future research priorities. Clinical recommendations emphasized relevant hemoglobin thresholds, and research recommendations emphasized a need for further understanding of physiologic thresholds, alternatives to RBC transfusion, and hemoglobin thresholds in populations with limited pediatric literature.

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Section: Discussionmentioning

confidence: 99%

Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

Doctor

Cholette

Remy

et al. 2018

Pediatric Critical Care Medicine

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show abstract

“…Recently, omics technologies have been applied to study RBCs under cold storage for use in transfusion medicine [ 8 ]. The transfusion of RBCs has long been an integral part of healthcare [ 9 – 11 ], with approximately 85 million RBC units transfused worldwide annually [ 12 ]. RBCs are stored in tightly-regulated, non-physiological conditions (i.e., packed in plastic blood bags in a static environment at 4°C), leading to many changes in the biochemical and physiological properties of RBCs.…”

Section: Introductionmentioning

confidence: 99%

Systems biology as an emerging paradigm in transfusion medicine

2018

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Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the “omic” data revolution and corresponding systems biology analytics. The red blood cell is the simplest human cell, making it an accessible starting point for the application of systems biology approaches.In this review, we discuss how the use of systems biology has led to significant contributions in transfusion medicine, including the identification of three distinct metabolic states that define the baseline decay process of red blood cells during storage. We then describe how a series of perturbations to the standard storage conditions characterized the underlying metabolic phenotypes. Finally, we show how the analysis of high-dimensional data led to the identification of predictive biomarkers.The transfusion medicine community is in the early stages of a paradigm shift, moving away from the measurement of a handful of chosen variables to embracing systems biology and a cell-scale point of view.

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“…With the Food and Drug Administration's requirement for use of 510 (k) cleared Blood Establishment Computer Systems, 3 large amounts of donor data are now available. 4 The second development was the advent of big data, in which extremely large data sets may be analyzed computationally to reveal patterns, trends, and associations, especially relating to human behavior and interactions. 5 Management of the blood supply is inherently challenging, with a complexity that is likely to increase in the years ahead, as donation rates wane yet populations age and may require more transfusions.…”

mentioning

confidence: 99%

Personalized medicine comes to a blood center near you

Gammon

2023

Transfusion

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Ultramassive transfusion: give blood, save a life

Cited by 3 publications

References 25 publications

Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

Systems biology as an emerging paradigm in transfusion medicine

Personalized medicine comes to a blood center near you

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