Ultraporous, Compressible, Wettable Polylactide/Polycaprolactone Sponges for Tissue Engineering

Mäder, Michael; Jérôme, Valérie; Freitag, Ruth; Agarwal, Seema; Greiner, Andreas

doi:10.1021/acs.biomac.8b00434

Cited by 49 publications

(54 citation statements)

References 48 publications

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“…Wettability (hydrophilicity/hydrophobicity) is governed by surface characteristics of the membrane including charge, chemistry, and roughness of the membrane . Membrane permeability governed by porosity and pore interconnectivity is also in important aspect of membrane design as it is essential for various processes facilitating cell growth such as nutrient absorption, and metabolic waste removal, but also for cell–cell signaling processes.…”

Section: Alveolar‐capillary Basement Membrane For Ali Cell Culturesmentioning

confidence: 99%

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Doryab

Taş

Taskin

et al. 2019

Adv Funct Materials

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Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator-induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role in lung growth, regeneration and disease development. In order to evaluate the impact of mechanical forces on the cellular level, in vitro models using lung cells on stretchable membranes have been developed. Only recently have some of these cell-stretching devices become suitable for air-liquid interface cell cultures, which is required to adequately model physiological conditions for the alveolar epithelium. To reach this goal, a multi-functional membrane for cell growth balancing biophysical and mechanical properties is critical to mimic (patho)physiological conditions. In this review, i) the relevance of cyclic mechanical forces in lung biology is elucidated, ii) the physiological range for the key parameters of tissue stretch in the lung is described, and iii) the currently available in vitro cell-stretching devices are discussed. After assessing various polymers, it is concluded that natural-synthetic copolymers are promising candidates for suitable stretchable membranes used in cell-stretching models. This work provides guidance on future developments in biomimetic in vitro models of the lung with the potential to function as a template for other organ models (e.g., skin, vessels).

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Section: Alveolar‐capillary Basement Membrane For Ali Cell Culturesmentioning

confidence: 99%

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Doryab

Taş

Taskin

et al. 2019

Adv Funct Materials

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“…e high customisation and easy functionalisation of the nanofibres offer numerous opportunities to control and to evaluate the morphology and/or chemical changes on the surface of blends, composites, and hybrids. SEM, transmission electron microscopy (TEM), and AFM may be valid tools for characterising surface topography and understanding the specific mechanical, chemical, and physical [63,69,70]. e parameters influencing the morphology and properties of electrospun fibres can be divided into solution parameters, process parameters, and ambient conditions.…”

Section: Electrospun Eco-friendly Polymer-based Blends Composites Amentioning

confidence: 99%

Scanning Electron Microscopy and Atomic Force Microscopy: Topographic and Dynamical Surface Studies of Blends, Composites, and Hybrid Functional Materials for Sustainable Future

Rydz

Šišková

Eckstein

2019

Advances in Materials Science and Engineering

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Microscopic techniques are often used in material science, enabling the assessment of the morphology, composition, physical properties, and dynamic behaviour of materials. The review focuses on the topographic and dynamical surface studies of (bio)degradable polymers, in particular aliphatic polyesters, the most promising ones. The (bio)degradation process promotes physical and chemical changes in material properties that can be characterised by microscopic techniques. These changes occurring both under controlled conditions as well as in the processing stage or during use indicate morphological and structural transformations resulting from the deterioration of the material and have a significant impact on the characteristic of materials used in many applications, for example, for use as packaging.

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“…Recently, the potential of electrospun fibers was reported for the fabrication of novel electrospun fibrous sponges by the use of short electrospun fibers . Owing to flexible fabrication conditions and diversified electrospun fibers, the sponges displayed tunable densities, multifunctionality, and applicability for various applications, for instance, reversible manual compression, hydrophilic or super hydrophobic, electrics, respirable open cells, or scaffolds for tissue engineering . Thus, these sponges could perfectly overcome the mechanical brittleness of traditional inorganic aerogel and high cost of carbon aerogel problems, making them a perfect candidate for broad applications due to their high potential for functionalization.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Fiber Length Distribution on Porous Sponges Originating from Short Electrospun Fibers Made from Polymer Yarn

Liao

Agarwal

et al. 2020

Macro Materials & Eng

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Recently, the potential of electrospun fibers was reported for the fabrication of novel electrospun fibrous sponges by the use of short electrospun fibers. [4,6,14,16] Owing to flexible fabrication conditions and diversified electrospun fibers, the sponges displayed tunable densities, multifunctionality, and applicability for various applications, for instance, reversible manual compression, [16] hydrophilic or super hydrophobic, [17,18] electrics, [19,20] respirable open cells, [21] or scaffolds for tissue engineering. [22,23] Thus, these sponges could perfectly overcome the mechanical brittleness of traditional inorganic aerogel and high cost of carbon aerogel problems, making them a perfect candidate for broad applications due to their high potential for functionalization.So far, almost all the concepts to obtain ultralight sponges consist of fabrication of short electrospun fiber suspensions by mechanical cutting and processing by self-assembly, followed by freeze-drying. [10] Normally, the short fibers obtained by using mechanical cutting devices, such as homogenizer, mixer, blender, grinder, exhibit uncontrollable length and broad length distribution represented by the high coefficient of variation (CV), [3,[24][25][26] which is defined as the ratio of the standard deviation to the mean length. Simultaneously, beyond several different reported methods, such as chemical treatment, [27] ultrasonication, [28] electric spark, [29] concentrated polymer brush, [30] and direct electrospinning, [31][32][33] the patterned UV-crosslinking [34] and microcutting method [35,36] based on highly aligned fibers enable the production of quasi-monodisperse short fibers. Short fiber dispersions with low CV have not been used to the best of our knowledge for the preparation of sponges. Consequently, the role of CV and fiber length in the morphology and mechanical properties of the sponges is unknown, which is, however, very important for basic understanding and numerous applications.Herein, we present a new method for the preparation of short electrospun fiber dispersions with controlled CV and use them for the preparation of the sponges in order to evaluate the microstructure and mechanical properties. We show the cryo-microcutting of multifibrillar highly oriented electrospun poly(acrylonitrile) (PAN) yarns which resulted finally in short individual PAN fibers of well-controlled length. Fiber dispersions of different CVs were obtained by mixing of short fibers of different lengths, which were used for the preparation of sponges following the established method. We could clearly Ultralight highly porous sponges made of short electrospun polymer fibers have gained significant attention for a variety of applications. According to the established procedures, short electrospun fibers are obtained by cutting or homogenization of electrospun fibers in suspension, which yield fibers with inhomogeneous fiber length. The role of the fiber length distribution and the fiber length in the mechanical compressibility of the sponges is unkn...

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Ultraporous, Compressible, Wettable Polylactide/Polycaprolactone Sponges for Tissue Engineering

Cited by 49 publications

References 48 publications

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Scanning Electron Microscopy and Atomic Force Microscopy: Topographic and Dynamical Surface Studies of Blends, Composites, and Hybrid Functional Materials for Sustainable Future

Impact of the Fiber Length Distribution on Porous Sponges Originating from Short Electrospun Fibers Made from Polymer Yarn

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