2014
DOI: 10.1021/am506403f
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Ultrasensitive and Selective Detection of Dopamine Using Cobalt-Phthalocyanine Nanopillar-Based Surface Acoustic Wave Sensor

Abstract: A highly selective and sensitive surface acoustic wave (SAW) sensor of dopamine (DA) was developed by depositing cobalt phthalocyanine (CoPc) nanopillars on gold-coated sensing platform of SAW sensor. The developed biosensor presents a sensitivity of 1.6°/nM, has a low limit of detection (LOD) on the order of 0.1 nM, and imparts more selectivity toward DA, since the detection limit of the interfering ascorbic acid (AA) is as high as 1 mM. To understand the selectivity mechanisms of this sensor toward DA, densi… Show more

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Cited by 33 publications
(18 citation statements)
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“…Therefore, determining the leakage of ammonia in ambient environment becomes critical. To achieve this goal, various types of ammonia sensors, such as metal oxide semiconductor sensors, electrochemical sensors and surface acoustic wave (SAW) sensors were developed, [13][14][15][16][17]. Benefiting from the significant development of RF and crystal technologies, surface acoustic wave techniques (SAWTs) are playing important roles in our daily life [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, determining the leakage of ammonia in ambient environment becomes critical. To achieve this goal, various types of ammonia sensors, such as metal oxide semiconductor sensors, electrochemical sensors and surface acoustic wave (SAW) sensors were developed, [13][14][15][16][17]. Benefiting from the significant development of RF and crystal technologies, surface acoustic wave techniques (SAWTs) are playing important roles in our daily life [18][19][20][21].…”
Section: Introductionmentioning
confidence: 99%
“…The level of receptor activation strongly depends on the dose administrated. The need for its accurate detection at physiological levels is largely the reason for the development of various techniques, ranging from electrochemistry [ 14 ], chromatography [ 15 ], and gravimetry [ 16 , 17 ], to optical spectroscopy [ 5 , 6 , 7 , 8 ]. From a chemical perspective, its ionizable functional groups—an ethyl ammonium, which acts as a proton acceptor, and two phenolic hydroxyls, which act as donors—can participate in DA molecular bonding.…”
Section: Introductionmentioning
confidence: 99%
“…From a chemical perspective, its ionizable functional groups—an ethyl ammonium, which acts as a proton acceptor, and two phenolic hydroxyls, which act as donors—can participate in DA molecular bonding. At physiological levels, the dominant presence of ionized DA has been reported from both experimental [ 14 , 15 , 18 ] and theoretical [ 16 , 17 , 19 ] results.…”
Section: Introductionmentioning
confidence: 99%
“…The developed gravimetric sensor consists of dual delay lines fabricated on 36° rot lithium tantalate piezoelectric substrates. The sensitive area and interdigital transducers (IDTs) were realized by evaporation of (20/80) nm Cr/Au layers [3]. The IDTs were patterned with a periodicity of λ = 40 µm which corresponds to an operating frequency of about 104 MHz.…”
Section: Instrumentationmentioning
confidence: 99%