Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid

Mahnashi, Mater H.; Mahmoud, Ashraf M.; Alhazzani, Khalid; Alanazi, Ahmed Z.; Alaseem, Ali; Algahtani, Mohammad; El-Wekil, Mohamed M.

doi:10.1007/s00604-021-04781-6

Cited by 52 publications

(8 citation statements)

References 46 publications

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“…The molecular imprinting technology presents the fabrication of imprinted sites within a synthesized polymeric film using an appropriate template. 14,15 Molecularly imprinted polymers (MIPs) are considered as highly efficient recognition elements because of their versatility and ability to introduce new binding sites for different kinds of compounds. [16][17][18][19] MIPs are widely used in the field of sensing and solid-phase microextraction.…”

Section: Introductionmentioning

confidence: 99%

A molecularly imprinted electrochemical sensor for specific and ultrasensitive determination of an aminoglycoside drug: the role of copper ions in the determination

El-wekil

Alhazzani

et al. 2023

Analyst

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Section: Introductionmentioning

confidence: 99%

A molecularly imprinted electrochemical sensor for specific and ultrasensitive determination of an aminoglycoside drug: the role of copper ions in the determination

El-wekil

Alhazzani

et al. 2023

Analyst

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“…It was formed by the electro-polymerization of the functional monomer around the template. Specific binding sites are formed after the removal of the template, capable of identifying the analyte under study 17 – 20 . Interestingly, we found only one report in the literature describing the electrochemical sensing of Pseudomonas aeruginosa based on the fabrication of molecular imprinted aptasensor immobilized on gold nanoparticles/polydopamine hybrid 21 .…”

Section: Introductionmentioning

confidence: 99%

An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au/Fe3O4 binary hybrid

El-Wekil

Halby

Darweesh

et al. 2022

Sci Rep

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Pathogenic bacteria cause disease outbreaks and threaten human health, prompting the research on advanced detection assays. Herein, we developed a selective molecular imprinted aptasensor for sensitive and prompt quantitation of Staphylococcus aureus (S. aureus) bacteria. The aptasensor was constructed by immobilization of aptamer on gold nanoparticles modified magnetic nanoparticles (apt-AuNPs@ Fe3O4). A functional monomer (o-phenylenediamine, o-phen) was electro-polymerized on the surface of the as-synthesized nanocomposite in the presence of a template (S. aureus). After removing S. aureus, the formed imprinted sites were available to extract pathogenic bacteria from complicated matrices. The surface morphology of the as-fabricated nanocomposites was characterized using different spectroscopic and electrochemical methods. Moreover, we thoroughly evaluated factors affecting the synthesis and determination procedures. The molecular imprinted aptasensor exhibited a wide linear range of 101–107 CFU mL−1 with a Limit of Detection, LOD (signal to noise = 3) of 1 CFU mL−1. The aptasensor detected S. aureus in milk, conduit water, and apple juice samples with good recoveries % and satisfactory relative standard deviations (RSDs %) values.

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“…[4][5][6] Therefore, COVID-19 was declared a global pandemic by the World Health Organization (WHO) in 2020, with several cases of over 630 million, and deaths of over 6.5 million. 7,8 Patients with COVID-19 disease are being treated with a variety of antiviral drugs that have previously been shown to be effective and safe against other viruses while vaccine studies are underway to combat it. 9 It is for this reason that several approved antiviral drugs for various infections are being tested in various parts of the globe which can positively affect COVID-19 treatment such as Favi and Moln, as well as new alternatives that are still in the testing stage.…”

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confidence: 99%

Simultaneous Electrochemical Quantification of Favipiravir and Molnupiravir as Antiviral Drugs for the Treatment of COVID-19 by Using a Glassy Carbon Electrode Modified by Pd/Co-Mn-MOF-74

Mahdavi Nejad

2024

J. Electrochem. Soc.

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Electrochemical monitoring of Favipiravir (Favi) and Molnupiravir (Moln) as effective drugs for the treatment of COVID-19 was conducted. A modification of the glassy carbon electrode (GCE) with metal-organic frameworks (MOFs) was applied for the determination process by using the square wave voltammetry (SWV) technique.Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD) techniques were applied to check the characterization of synthesized modified-MOFs. In Britton–Robinson buffer solutions (BR) with pH 7, two well-defined peaks appeared on the Pd/Co-Mn-MOF-74/GCE for 10 μM Moln and Favi were 423 and 1143 mV while the oxidation currents were 32.6 and 18.4 µA, respectively. The detection limit for Moln and Favi were calculated based on 3 signal/noise as 0.002 and 0.003 µM, respectively. The ability of the Pd/Co-Mn-MOF-74/GCE was checked by monitoring the Moln and Favi in urine and blood and comparing the obtained data with HPLC data. The obtained data were in good agreement with each other which demonstrates that the presented method was one of the best analytical methods for the monitoring of Moln and Favi in the laboratory.

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Ultrasensitive and selective molecularly imprinted electrochemical oxaliplatin sensor based on a novel nitrogen-doped carbon nanotubes/Ag@cu MOF as a signal enhancer and reporter nanohybrid

Cited by 52 publications

References 46 publications

A molecularly imprinted electrochemical sensor for specific and ultrasensitive determination of an aminoglycoside drug: the role of copper ions in the determination

A molecularly imprinted electrochemical sensor for specific and ultrasensitive determination of an aminoglycoside drug: the role of copper ions in the determination

An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au/Fe3O4 binary hybrid

Simultaneous Electrochemical Quantification of Favipiravir and Molnupiravir as Antiviral Drugs for the Treatment of COVID-19 by Using a Glassy Carbon Electrode Modified by Pd/Co-Mn-MOF-74

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