Ultrasensitive Biosensors Detecting m6A in Blood: Achieving Early Screening and Typing of Tumors
Haiping Li,
Xixiang Xie,
Xiyu Liu
et al.
Abstract:N 6 -methyladenosine (m 6 A) modification is one of the most widespread RNA modifications in eukaryotes and is involved in cancer development and progression by regulating oncogene expression. Herein, a reticulated rolling circle amplification (RCA) cascade reaction was used to construct a novel electrochemical biosensor for ultrasensitive detection of m 6 A, employing ferrocene-tyramine (Fc-Tyr) molecules as electroactive probes. In this strategy, the RCA cascade reaction not only amplifies specific circular … Show more
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