Ultrasensitive Detection of Antiseptic Antibiotics in Aqueous Media and Human Urine Using Deep UV Resonance Raman Spectroscopy

Domes, Christian; Domes, Robert; Popp, Jürgen; Pletz, Mathias W.; Frosch, Torsten

doi:10.1021/acs.analchem.7b02422

Cited by 49 publications

(42 citation statements)

References 61 publications

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“…Mass spectrometry (MS) is a highly selective and sensitive technique, thereby enabling colistin quantification in different matrices, especially human plasma [102]. This drug’s molecule has little ultraviolet (UV) absorption and no fluorescence, which is why techniques such as UV spectroscopy are not frequently used for its quantification [103]. Table 8 shows the analytical method used for determining colistin in plasma.…”

Section: Colistin Plasma Level Measurementsmentioning

confidence: 99%

An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection

et al. 2019

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Antimicrobial resistance to antibiotic treatment has significantly increased during recent years, causing this to become a worldwide public health problem. More than 70% of pathogenic bacteria are resistant to at least one of the currently used antibiotics. Polymyxin E (colistin) has recently been used as a “last line” therapy when treating Gram-negative multi-resistant bacteria. However, little is known about these molecules’ pharmacological use as they have been discontinued because of their high toxicity. Recent research has been focused on determining colistimethate sodium’s pharmacokinetic parameters to find the optimal dose for maintaining a suitable benefit–risk balance. This review has thus been aimed at describing the use of colistin on patients infected by multi-drug resistant bacteria and the importance of measuring this drug’s plasma levels in such patients.

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Section: Colistin Plasma Level Measurementsmentioning

confidence: 99%

An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection

et al. 2019

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“…They discussed the potential of DUV resonant Raman microscopy for assessing pharmaceutical products. Domes et al detected antiseptic antibiotics at the low concentration in human urine . They discussed application of DUV resonant Raman spectroscopy for treating sepsis, where rapid online monitoring of clinically relevant antibiotics is important.…”

Section: Resonant Raman Scattering For Imaging and Analysismentioning

confidence: 99%

Deep‐Ultraviolet Biomolecular Imaging and Analysis

Kumamoto

Taguchi

Kawata

2018

Advanced Optical Materials

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Deep‐ultraviolet light, 200–300 nm in wavelength, interacts with nucleic acids and proteins strongly compared to visible and infrared light. In this article, the interaction between deep‐ultraviolet photons and biomolecules is discussed. Especially, the absorption and autofluorescence of biomolecules by the deep‐ultraviolet excitation are examined. Applications of deep‐ultraviolet absorption and autofluorescence to label‐free biomolecular imaging and analysis of cells and tissues are shown. Resonant Raman scattering at nucleotide bases and aromatic amino acids as another important topic of deep‐ultraviolet photonics is reviewed in biomolecular imaging and analysis. The discussion extends to the recent progress in the development of deep‐ultraviolet microscopes as well as a variety of deep‐ultraviolet optical devices such as light sources, detectors, and objectives. The issue of photodamage due to deep‐ultraviolet irradiation on cells and tissues is also discussed. It has been recently suppressed with use of lanthanide ions. The experimental results of the photodamage suppression are shown. For surface‐enhanced resonant Raman scattering, autofluorescence enhancement, and tip‐enhanced resonant Raman scattering microscopy, plasmonic materials applicable in the deep‐ultraviolet range are discussed.

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“…Raman spectroscopic methods are based on intrinsic molecular vibrations [8,9,10,11,12,13,14] and provide an extremely high chemical selectivity [15,16,17,18,19,20,21,22]. The technique is direct and non-invasive [23,24,25], can be miniaturized, and is also available for on-site applications [26,27,28].…”

Section: Introductionmentioning

confidence: 99%

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis

et al. 2019

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The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet® and self-made model tablets, which were used as examples of counterfeits and substandard. Partial least-squares regression modeling and density functional theory calculations were carried out for quantification of lumefantrine and artemether and for spectral band assignment. The most prominent differentiating vibrational signatures of the APIs were presented.

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Ultrasensitive Detection of Antiseptic Antibiotics in Aqueous Media and Human Urine Using Deep UV Resonance Raman Spectroscopy

Cited by 49 publications

References 61 publications

An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection

An Approach to Measuring Colistin Plasma Levels Regarding the Treatment of Multidrug-Resistant Bacterial Infection

Deep‐Ultraviolet Biomolecular Imaging and Analysis

Counterfeit and Substandard Test of the Antimalarial Tablet Riamet® by Means of Raman Hyperspectral Multicomponent Analysis

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