Ultrasensitive Electrochemical Platform for Dopamine Detection Based on CoNi-MOF@ERGO Composite

Abstract

An electrochemical sensor applied for dopamine (DA) detection was constructed. An easy static way was used to synthesize bimetallic CoNi-MOF. Next, it was mixed with graphene oxide (GO) under ultrasound to get a uniform suspension. Subsequently, the solution was coated on the glassy carbon electrode (GCE) to form CoNi-MOF@ERGO/GCE by the electrochemical reduction method. The interaction between CoNi-MOF and electrochemically reduced graphene oxide (ERGO) enhances the electrocatalytic performance for DA detection. CoNi-MOF@ERGO/GCE has a wider linear range (0.1−400 μM) and a lower detection limit (0.086 μM) under optimum conditions. Furthermore, it has been applied to test DA in human serum samples. The results reveal that the DA sensor shows excellent performance, which will provide a novel idea for more sensitive and quicker DA detection.

Bimetallic Coordination Polymers: Synthesis and Applications in Biosensing and Biomedicine

“…The constructed sensor had a linear range of 5 nM–177.8 μM with a detection limit of 1.67 nM (S/N = 3) at a potential of 0.1 V and exhibited promising selectivity for DA. The Shuang group has fabricated CoNi-MOF@ERGO (ERGO = electrochemically reduced graphene oxide) composite combining CoNi-MOF with ERGO on a glassy carbon electrode by electrochemical reduction method [ 111 ]. Co 2+ and Ni 2+ in the composites served as active sites to accelerate electron transfer and 2-methylimidazole as adsorption sites to enhance the enrichment of DA.…”