Ultrasensitive electrochemiluminescence aptasensor for kanamycin detection based on silver nanoparticle-catalyzed chemiluminescent reaction between luminol and hydrogen peroxide

Cheng, Songbai; Liu, Huimin; Zhang, Hui; Chu, Guanglei; Guo, Yemin

doi:10.1016/j.snb.2019.127367

Cited by 102 publications

(30 citation statements)

References 39 publications

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“…The recognition of kanamycin by the aptamer caused an obvious decrease in the ECL signal. The label-free ECL sensing platform displayed a wide linear range from 0.8-170 nM, with a limit of detection of 0.1 nM [73]. Higher sensitivity (0.16 pM) was obtained based on ECL-resonance energy transfer between CDs and Au-GO composite [74].…”

Section: Electrochemiluminescencementioning

confidence: 99%

Recent Advances in Optical Detection of Aminoglycosides

Zhou

Cao

2020

Applied Sciences

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Aminoglycosides (AGs) are broad-spectrum antibiotics used in both human infection and animal medicine. The overuse of AGs causes undesirable residues in food, leading to serious health problems due to food chain accumulation. In recent years, various methods have been developed to determine AGs in food. Among these methods, fluorescent (FL), colorimetric and chemiluminescent (CL) optical methods possess advantages such as their simple instrumentation, low cost, simple operation, feasibility of realizing visualization, and smartphone imaging. This mini-review summarizes optical assays for the detection of AGs in food developed in recent years. The detection principles for different categories are discussed. Then, the amplification techniques for the ultrasensitive detection of AGs are introduced. We also discuss multiplex methods for the simultaneous detection of AGs. Finally, the challenges and future prospects are discussed in the Conclusions and Perspectives section.

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Section: Electrochemiluminescencementioning

confidence: 99%

Recent Advances in Optical Detection of Aminoglycosides

Zhou

Cao

2020

Applied Sciences

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“…As it is the case with fluorescence and colorimetric aptasensors, the use of nanomaterials in CL aptasensors allows for improvement in their sensitivity and selectivity. Nanomaterials can be used to accelerate the decomposition of luminol in the presence of hydrogen peroxide (e.g., AgNPs [151]) to increase the signal and, hence, to improve the sensitivity of the aptasensor. In addition to catalyzing the reaction (i.e., facilitation of the electron transfer), nanoparticles are good carriers for immobilizing aptamers.…”

Section: Chemiluminescent (Cl) Aptasensorsmentioning

confidence: 99%

The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products

Gaudin¹

2020

Biosensors

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The presence of antimicrobial residues in food-producing animals can lead to harmful effects on the consumer (e.g., allergies, antimicrobial resistance, toxicological effects) and cause issues in food transformation (i.e., cheese, yogurts production). Therefore, to control antimicrobial residues in food products of animal origin, screening methods are of utmost importance. Microbiological and immunological methods (e.g., ELISA, dipsticks) are conventional screening methods. Biosensors are an innovative solution for the development of more performant screening methods. Among the different kinds of biosensing elements (e.g., antibodies, aptamers, molecularly imprinted polymers (MIP), enzymes), aptamers for targeting antimicrobial residues are in continuous development since 2000. Therefore, this review has highlighted recent advances in the development of aptasensors, which present multiple advantages over immunosensors. Most of the aptasensors described in the literature for the detection of antimicrobial residues in animal-derived food products are either optical or electrochemical sensors. In this review, I have focused on optical aptasensors and showed how nanotechnologies (nanomaterials, micro/nanofluidics, and signal amplification techniques) largely contribute to the improvement of their performance (sensitivity, specificity, miniaturization, portability). Finally, I have explored different techniques to develop multiplex screening methods. Multiplex screening methods are necessary for the wide spectrum detection of antimicrobials authorized for animal treatment (i.e., having maximum residue limits).

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“…In comparison to antibodies, aptamers offer the following advantages: rather simple manufacture, easy modification, higher chemical and thermal stability in storage, and operation in the assembly of aptasensors [ 19 ]. Regarding KANA, several aptasensors have been described [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. In them, specific aptamers have mostly been immobilized via terminal amino- or thiol-groups on appropriate carriers (carbon nanotubes, metal nanoparticles, Au electrode surface).…”

Section: Introductionmentioning

confidence: 99%

“…The sensitivity can be additionally enhanced by labeling the aptamer with horseradish peroxidase [ 22 ], ferrocene [ 23 , 25 ], and Methylene blue [ 26 , 27 ]. Combination of the aptamer-analyte binding with electrochemiluminescent luminol oxidation [ 24 ] and the strand displacement protocol [ 25 , 26 , 27 , 28 ] were also described. In them, the aptamer was hybridized with auxiliary DNA sequence, which was released after the KANA binding.…”

Section: Introductionmentioning

confidence: 99%

Impedimetric Determination of Kanamycin in Milk with Aptasensor Based on Carbon Black-Oligolactide Composite

Kulikova

Gorbatchuk

Стойков

et al. 2020

Sensors

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The determination of antibiotics in food is important due to their negative effect on human health related to antimicrobial resistance problem, renal toxicity, and allergic effects. We propose an impedimetric aptasensor for the determination of kanamycin A (KANA), which was assembled on the glassy carbon electrode by the deposition of carbon black in a chitosan matrix followed by carbodiimide binding of aminated aptamer mixed with oligolactide derivative of thiacalix[4]arene in a cone configuration. The assembling was monitored by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy. In the presence of the KANA, the charge transfer resistance of the inner interface surprisingly decreased with the analyte concentration within 0.7 and 50 nM (limit of detection 0.3 nM). This was attributed to the partial shielding of the negative charge of the aptamer and of its support, a highly porous 3D structure of the surface layer caused by a macrocyclic core of the carrier. The use of electrostatic assembling in the presence of cationic polyelectrolyte decreased tenfold the detectable concentration of KANA. The aptasensor was successfully tested in the determination of KANA in spiked milk and yogurt with recoveries within 95% and 115%.

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Ultrasensitive electrochemiluminescence aptasensor for kanamycin detection based on silver nanoparticle-catalyzed chemiluminescent reaction between luminol and hydrogen peroxide

Cited by 102 publications

References 39 publications

Recent Advances in Optical Detection of Aminoglycosides

Recent Advances in Optical Detection of Aminoglycosides

The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products

Impedimetric Determination of Kanamycin in Milk with Aptasensor Based on Carbon Black-Oligolactide Composite

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