Ultrasensitive immunoassay of glycoprotein 125 (CA 125) in untreated human plasma samples using poly (CTAB‑chitosan) doped with silver nanoparticles

Hasanzadeh, Mohammad; Mohammadzadeh, Arezoo; Jafari, Mohsen; Habibi, Biuck

doi:10.1016/j.ijbiomac.2018.09.208

Cited by 39 publications

(8 citation statements)

References 57 publications

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“…In ovarian cancer, chitosan oligosaccharide has been demonstrated to have an antiproliferative effect on SKOV‐3 cells and induce apoptosis in a dose‐dependent manner . Hasanzadeh et al used a nanocomposite consisting of poly cetyl trimethyl ammonium bromide and chitosan in combination with silver NPs. This nanocomposite film was used as a sensitive immunosensor in order to detect the CA 125 protein, a mucin glycoprotein that is associated with the risk of developing ovarian cancer .…”

Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

“…Hasanzadeh et al used a nanocomposite consisting of poly cetyl trimethyl ammonium bromide and chitosan in combination with silver NPs. This nanocomposite film was used as a sensitive immunosensor in order to detect the CA 125 protein, a mucin glycoprotein that is associated with the risk of developing ovarian cancer . In another investigation, researchers used a nanoplatform composed of Rose bengal molecules, chitosan, poly(vinyl alcohol), branched polyethylenimine, and iron oxide NPs for the on‐demand release of drugs for photodynamic therapy .…”

Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

“…This nanocomposite film was used as a sensitive immunosensor in order to detect the CA 125 protein, a mucin glycoprotein that is associated with the risk of developing ovarian cancer. 38 In another investigation, researchers used a nanoplatform composed of Rose bengal molecules, chitosan, poly(vinyl alcohol), branched polyethylenimine, and iron oxide NPs for the on-demand release of drugs for photodynamic therapy. 39 Rose Bengal molecules resulted in the photo-oxidation process, which caused the simultaneous release of guest molecules such as PTX.…”

Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

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Chitosan is a potential inhibitor of ovarian cancer: Molecular aspects

et al. 2019

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Although ovarian cancer has a lower prevalence than breast cancer, its mortality rate is three times higher, which is reported to increase in the coming years. As the early stages of ovarian cancer do not have any obvious symptoms, in most of the cases, this cancer is diagnosed at advanced stages with a poor prognosis. Moreover, in many patients who are diagnosed with advanced stage, relapse of the disease and drug resistance are observed. Over the past years, these women have been treated with chemotherapy and cytoreductive surgeries. However, the chemotherapy could affect the healthy tissues in addition to the malignancies. Therefore, discovering new diagnostic and therapeutic options seems to be a crucial need. Unlike the common invasive and/or nonspecific treatments, nanomedicine is trying to find a new way for cancer imaging, diagnosis, and drug delivery method. Nanoparticles (NPs), which has recently drawn attention, can be used in order to reduce the toxicity and frequent dosing of drugs, tumor‐specific delivery, and early diagnosis for malignancies. Chitosan as an NP and product of chitin deacetylation has multiple characteristics, including biocompatibility, biodegradability, and safety. In this review, we cover the studies concerned with the role of chitosan in finding solutions to overcome the problems faced in ovarian cancer treatments. Furthermore, we highlight how chitosan is being used in delivering chemotherapy drugs, gene therapy, and imaging methods for both detection and image‐guided therapies.

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Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

Section: Chitosan Roles In Diagnosis and Treatment Of Cancersmentioning

confidence: 99%

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Chitosan is a potential inhibitor of ovarian cancer: Molecular aspects

et al. 2019

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“…Ayrıca, yüzey aktif maddeler (surfaktant), elektron transferini hızlandırmak ve elektrot yüzey alanını arttırmak için, elektrokimyasal algılama platformlarında kullanılan başka bir tür malzemedir. Bu bağlamda, nanomateryallerle birleştirilmiş yüksek hassasiyet ve seçicilik gibi üstün özelliklere sahip katyonik bir yüzey aktif madde olan setiltrimetil amonyum bromür (CTAB), mükemmel katalitik aktivite, farklı analitlerin tespitine yönelik biyosensörleri geliştirmek için son zamanlarda yaygın olarak kullanılmaya başlanmıştır [28,29].…”

Section: Introductionunclassified

“…Elde edilen yanıtın artan Fe(III)/Fe(II) redoks prosesinin yanısıra yapıda bulunan bromür iyonlarının redox davranışına neden olduğu şeklinde yorumlandı. Literatürde, benzer voltametrik davranış, farklı malzemelerle birleştirilmiş CTAB modifiye elektrotlarda da elde edilmiştir[28]. Bu film üzerine iletken olmayan HSA NP kaplanması ise, bu elektroda ait CV'B.…”

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İnsan Serum Albümin Nanopartikül/surfaktant Polimer Temelli Sensör ile Metil Paratiyonun Enzimsiz Elektroanalizi

Bolat

2021

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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Bu çalışmada, insan serum albümin nanopartiküller (HSA NP) ve elektrobiriktirilmiş yüzey aktif polisetiltrimetil amonyum bromür p(CTAB) film kaplı grafit elektrotlar (PGE) tehlikeli bir çevresel kirletici olan metil paratiyonun (MP) hassas ve seçici tespiti için elektrokimyasal sensör olarak kullanıldı. Elde edilen HSA NP/p(CTAB)/PGE mikroskopik ve elektrokimyasal olarak karakterize edildi. Diferansiyel puls voltametri (DPV) tekniği ile MP için elde edilen doğrusal çalışma aralığı 0,01-0,1 µM ve gözlenebilme sınırı ise 6 nM olarak tespit edildi. MP tespiti için geliştirilen enzim kullanımı gerektirmeyen ve basit hazırlama stratejisine sahip HSA NP/p(CTAB) tabanlı elektrokimyasal sensör, çevre koruma ve gıda güvenliği açısından izleme sürecini de basitleştirme potansiyeline sahiptir.

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