Ultrasensitive sensing urinary cystatin C via an interface-engineered graphene extended-gate field-effect transistor for non-invasive diagnosis of chronic kidney disease

Chen, Xiaofen; Liang, Yirou; Tang, Ning; Li, Canye; Zhang, Yongheng; Xu, Feng; Shi, Guoyue; Zhang, Min

doi:10.1016/j.bios.2024.116016

Cited by 9 publications

(1 citation statement)

References 37 publications

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“…Predominantly reabsorbed and metabolized in the proximal tubule, it exhibits minimal excretion in urine [75]. Urinary CysC levels closely correlate with both the early stages and progression of CKD, making it an optimal endogenous marker for assessing renal function impairment [76]. The current results revelated that patients who did not improve their IFC after the 2-year intervention had significantly increased CysC/Cr levels.…”

Section: Discussionmentioning

confidence: 54%

Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial

Quetglas-Llabrés,

Monserrat-Mesquida,

Bouzas

et al. 2024

Antioxidants

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Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease observed in clinical practice worldwide. This disorder has been independently associated with an increased risk of developing chronic kidney disease (CKD). The aim of this study was to evaluate whether a 2-year intervention based on a Mediterranean diet (MedDiet) and physical activity focussed on reducing intrahepatic fat contents (IFC) was associated with a decreased risk of CKD. Forty adults (50% women) residing in Mallorca, aged 48 to 60 years, diagnosed with MAFLD were recruited. Participants were divided into two groups based on whether they improved IFC measured by nuclear magnetic resonance. Anthropometric and clinical parameters improved in responders, including reduced weight, body mass index (BMI), and waist circumference. Only responders showed improvements in lipid profile and liver enzymes. Haematological parameters showed favourable changes in both groups. Oxidative stress and inflammatory biomarkers differed between groups. Responders had lower plasma interleukine-18 (IL-18) levels, but higher erythrocyte malonaldehyde (MDA) levels. Non-responders showed increased erythrocyte catalase and superoxide dismutase activity. After 2 years, non-responders had higher serum creatinine, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) levels, while responders showed reductions in these parameters together with uric acid and urine albumin-to-creatinine ratio (UACR). Positive correlations were found between changes in IFC and kidney injury biomarkers, including MDRD and serum creatinine levels. In conclusion, a healthy diet based on the Mediterranean dietary pattern and lifestyle promotes significant improvements in parameters related to cardiovascular, hepatic, and renal health.

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Section: Discussionmentioning

confidence: 54%

Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial

Quetglas-Llabrés,

Monserrat-Mesquida,

Bouzas

et al. 2024

Antioxidants

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Dual Recognition Strategy‐Based Transistor Sensor Array for Ultrasensitive and Multi‐Target Detection of Antibiotics

Tao,

Wei,

et al. 2024

Adv Funct Materials

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Multi‐target detection is a notable development direction in the field of analytical methods, boasting significant potential for breakthroughs in complex sample detection. Herein, an extended gate field‐effect transistor (EGFET) sensor array for ultrasensitive and multi‐target detection of antibiotics is developed. To enhance the recognition ability for diverse antibiotics, a dual‐recognition strategy based on tailor‐made molecularly imprinted polymer (MIP) and aptamer is adopted to fabricate the extended gate electrode (sensing electrode). The dual‐recognition strategy‐based EGFET exhibits superior sensitivity, selectivity, and stability compared to single recognition probes due to the synergistic effect of the affinities of MIP and specific aptamer. The developed sensor array can detect three types of antibiotics, including ampicillin, amoxicillin, and kanamycin, at the same time with record‐low detection limit (fM level) and a detection range spanning six orders of magnitude. The practical detection of antibiotics in various samples (tap water, river water, milk, honey, and artificial urine) further validates the feasibility of the sensor array in practical applications. The key advantages of flexibility, high sensitivity and selectivity, and multifunctionality demonstrate the high potential of EGFET sensor array for simultaneous detection of multiple target molecules.

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2D Materials‐Based Field‐Effect Transistor Biosensors for Healthcare

Li,

Wijaya,

Jang

et al. 2024

Small

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The need for accurate point‐of‐care (POC) tools, driven by increasing demands for precise medical diagnostics and monitoring, has accelerated the evolution of biosensor technology. Integrable 2D materials‐based field‐effect transistor (2D FET) biosensors offer label‐free, rapid, and ultrasensitive detection, aligning perfectly with current biosensor trends. Given these advancements, this review focuses on the progress, challenges, and future prospects in the field of 2D FET biosensors. The distinctive physical properties of 2D materials and recent achievements in scalable synthesis are highlighted that significantly improve the manufacturing process and performance of FET biosensors. Additionally, the advancements of 2D FET biosensors are investigated in fatal disease diagnosis and screening, chronic disease management, and environmental hazards monitoring, as well as their integration in flexible electronics. Their promising capabilities shown in laboratory trials accelerate the development of prototype products, while the challenges are acknowledged, related to sensitivity, stability, and scalability that continue to impede the widespread adoption and commercialization of 2D FET biosensors. Finally, current strategies are discussed to overcome these challenges and envision future implications of 2D FET biosensors, such as their potential as smart and sustainable POC biosensors, thereby advancing human healthcare.

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Ultrasensitive sensing urinary cystatin C via an interface-engineered graphene extended-gate field-effect transistor for non-invasive diagnosis of chronic kidney disease

Cited by 9 publications

References 37 publications

Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial

Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial

Dual Recognition Strategy‐Based Transistor Sensor Array for Ultrasensitive and Multi‐Target Detection of Antibiotics

2D Materials‐Based Field‐Effect Transistor Biosensors for Healthcare

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