Ultrasensitive SERS Nanoprobes for Hazardous Metal Ions Based on Trimercaptotriazine-Modified Gold Nanoparticles

Zamarion, Vitor M.; Timm, Ronaldo Adriano; Araki, Koji; Toma, Henrique E.

doi:10.1021/ic800122v

Cited by 126 publications

(102 citation statements)

References 20 publications

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“…(C) Formation of coordination compounds between L-cysteine (absorbed on Ag NPs) and metal ions (F. Li et al, 2013). (D) Proposed binding mode on Au NPs for (a) Trimercaptotriazine (TMT), (b) Hg 2+ , and (c) Cd 2+ (Zamarion et al, 2008). (E) Multiple heavy metal ions can be identified and quantified using SERS spectra of 2-mercap-toisonicotinic acid (2MNA, Tan et al, 2012).…”

Section: Hairpin Structural-based Methodsmentioning

confidence: 99%

“…For example, Zamarion et al (2008) modified Au NPs with trimercaptotriazine to detect Hg 2+ and Cd 2+ (Fig. 4D).…”

Section: Reporter Attachmentmentioning

confidence: 99%

“…However, direct SERS detection of monoatomic metal ions, such as Hg 2+ , is challenging due to their small scattering cross section Alvarez-Puebla and Liz-Marzan, 2012). This is why the SERS sensing of Hg 2+ was first reported in 2008, about 35 years since the discovery of the SERS effect (Zamarion et al, 2008). Recently, the number of publications and citations of SERS in Hg 2+ detection has increased significantly (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Recent progress in detection of mercury using surface enhanced Raman spectroscopy — A review

Sun

Jing

2016

Journal of Environmental Sciences

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Concerns over exposure to mercury have motivated the exploration of cost-effective, rapid, and reliable method for monitoring Hg 2+ in the environment. Recently, surface-enhanced Raman scattering (SERS) has become a promising alternative method for Hg 2+ analysis. SERS is a spectroscopic technique which combines modern laser spectroscopy with the optical properties of nano-sized noble metal structures, resulting in substantially increased Raman signals. When Hg 2+ is in a close contact with metallic nanostructures, the SERS effect provides unique structural information together with ultrasensitive detection limits.This review introduces the principles and contemporary approaches of SERS-based Hg 2+ detection. In addition, the perspective and challenges are briefly discussed.

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Section: Hairpin Structural-based Methodsmentioning

confidence: 99%

“…For example, Zamarion et al (2008) modified Au NPs with trimercaptotriazine to detect Hg 2+ and Cd 2+ (Fig. 4D).…”

Section: Reporter Attachmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent progress in detection of mercury using surface enhanced Raman spectroscopy — A review

Sun

Jing

2016

Journal of Environmental Sciences

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“…Considering that many factors could affect the SERS intensity in SERS detection, the SERS methods for Hg 2+ detection employing SERS intensity ratios of related bands were developed. A trimercaptotriazine (TMT)-modified Au NPs based SERS sensor for Hg 2+ and Cd 2+ in aqueous solution was developed by Zamarion et al [122]. This sensor allowed the quantitative detection of Hg 2+ and Cd 2+ by using relative SERS intensity ratios of the selected bands.…”

Section: Reviewsmentioning

confidence: 99%

Recent developments on nanomaterials-based optical sensors for Hg2+ detection

Duan

Zhan

2015

Sci. China Mater.

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Mercuric ion (Hg 2+ ), released from both natural and industrial sources, has severe adverse effects on human health and the environment even at very low concentrations. It is very important to develop a rapid and economical method for the detection of Hg 2+ with high sensitivity and selectivity. Nanomaterials with unique size and shape-dependent optical properties are attractive sensing materials. The application of nanomaterials to design optical sensors for Hg 2+ provides a powerful method for the trace detection of Hg 2+ in the environment, because these optical sensors are simple, rapidly responsive, cost-effective and highly sensitive. This review summarizes the recent advances on the development of optical assays for Hg 2+ in aqueous solution by using functionalized nanomaterials (including noble metal nanoparticles, fluorescent metal nanoclusters, semiconductor quantum dots and carbon nanodots). Detection strategies based on the Hg 2+ -induced changes in spectral absorbance, fluorescence intensity and surface-enhanced Raman scattering signals were described. And the design principles for each optical assay were presented. In addition, the future challenge and the prospect of the development of nanomaterial optical sensors for Hg 2+ detection were also discussed.

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“…For example, Zamarion's group reported ultrasensitive SERS nanoprobes for hazardous metal ions based on trimercaptotriazine-modified gold nanoparticles (Au NPs). 27 Wang's group developed a direct SERS technique for Hg 2+ detection based on the investigation of the interaction between silver nanoparticles (Ag NPs) and Hg 2+ . 28 Our group has also developed an SERS approach to detect As 3+ by using glutathione-functionalized Ag NPs and 4-MPY as the Raman reporter.…”

Section: ■ Introductionmentioning

confidence: 99%

Highly Sensitive Surface-Enhanced Raman Scattering Sensing of Heparin Based on Antiaggregation of Functionalized Silver Nanoparticles

Wang

Chen

et al. 2013

ACS Appl. Mater. Interfaces

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We report a simple and sensitive surface-enhanced Raman scattering (SERS) platform for the detection of heparin, based on antiaggregation of 4-mercaptopyridine (4-MPY) functionalized silver nanoparticles (Ag NPs). Here, protamine was employed as a medium for inducing the aggregation of negatively charged 4-MPY functionalized Ag NPs through surface electrostatic interaction, which resulted in significantly enhanced Raman signal of the Raman reporter. However, in the presence of heparin, the interaction between heparin and protamine decreased the concentration of free protamine, which dissipated the aggregated 4-MPY functionalized Ag NPs and thus decreased Raman enhancement effect. The degree of aggregation and Raman enhancement effect was proportional to the concentration of added heparin. Under optimized assay conditions, good linear relationship was obtained over the range of 0.5−150 ng/mL (R 2 = 0.998) with a minimum detectable concentration of 0.5 ng/mL in standard aqueous solution. Furthermore, the developed method was also successfully applied for detecting heparin in fetal bovine serum samples with a linear range of 1−400 ng/mL.

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Ultrasensitive SERS Nanoprobes for Hazardous Metal Ions Based on Trimercaptotriazine-Modified Gold Nanoparticles

Cited by 126 publications

References 20 publications

Recent progress in detection of mercury using surface enhanced Raman spectroscopy — A review

Recent progress in detection of mercury using surface enhanced Raman spectroscopy — A review

Recent developments on nanomaterials-based optical sensors for Hg2+ detection

Highly Sensitive Surface-Enhanced Raman Scattering Sensing of Heparin Based on Antiaggregation of Functionalized Silver Nanoparticles

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