“…Many detection systems have been developed by making use of enzymes as amplifiers because of the low abundance of targets in natural environments. Amplificatory tools, such as polymerase (Manrao et al, 2012), ligase (Shen et al, 2012;Wee et al, 2012) and exonuclease (Ju et al, 2012;Xuan et al, 2012), in DNA detection offer exquisite sensitivity and are commonly used to follow target-probe hybridization. However, these enzyme-based assays are labor-intensive, require complex operation, and have a relatively high cost.…”