Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets

Piestrzyńska, Monika; Dominik, Magdalena; Kosiel, Kamil; Janczuk-Richter, Marta; Szot-Karpińska, Katarzyna; Brzozowska, Ewa; Shao, Liyang; Niedziółka‐Jönsson, Joanna; Bock, Wojtek J.; Śmietana, Mateusz

doi:10.1016/j.bios.2019.03.006

Cited by 59 publications

(23 citation statements)

References 39 publications

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“…S4 in supplementary document. The add layer sensitivity (S t h ) can be as high as ∼25 pm/nm attachment of analyte by an experimentally demonstrated overlay RI of ∼2 with tantalum oxide overlays [37]. With a standard interrogation technique 1 pm resolution change in resonance wavelength could be observed, so (1/25) = ∼ 0.04 nm or 40 pm attachment of target analyte could be detected with highly sensitive cladding mode of FBG.…”

Section: Numerical Resultsmentioning

confidence: 99%

Employing Higher Order Cladding Modes of Fiber Bragg Grating for Analysis of Refractive Index Change in Volume and at the Surface

et al. 2020

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In this work, a detailed study on volume and surface refractive index (RI) sensitivity of cladding modes for a fiber Bragg grating (FBG) based sensor is presented. Surface RI sensitivity of the cladding mode of FBGs has been illustrated and quantified with the concept of add-layer sensitivity for the first time to the best of our knowledge. A detailed investigation of mode transition of higher-order cladding modes has been revisited and important characteristics of the cladding modes are observed which could open a new designing path of fabrication and innovative way of the use of this family of optical fiber grating-based sensors. The effect of "mode transition" of higher-order cladding modes, higher operating wavelength for respective cladding mode and "mode stretching" effects are combined together to achieve higher volume and surface RI sensitivity of cladding mode of FBG. It has been shown numerically that with proper designing, sub-nanometer (∼0.04 nm) attachment of target analyte could be recognized by cladding mode of FBG which is quite promising for application in optical fiber grating bio-sensors. This critical designing method of FBG based surface refractometer would be very helpful in case of the fabrication of highly sensitive sensors for distinct biochemical applications.

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Section: Numerical Resultsmentioning

confidence: 99%

Employing Higher Order Cladding Modes of Fiber Bragg Grating for Analysis of Refractive Index Change in Volume and at the Surface

et al. 2020

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“…Future work should focus on the measurements of norovirus samples to confirm the applicability of our sensor design for norovirus infection diagnostics. Additionally, the repeatability and sensitivity of the LPFG sensor may be improved by tuning the dispersion turning point and applying a high-refractive-index coating such as TiO x [34] or TaO x [35].…”

Section: Discussionmentioning

confidence: 99%

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Janczuk-Richter

Gromadzka

Richter

et al. 2020

Sensors

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Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensitive, and selective optical fiber biosensor for the detection of norovirus virus-like particles (VLPs) is reported. The sensor is based on highly sensitive long-period fiber gratings (LPFGs) coated with antibodies against the main coat protein of the norovirus. Several modification methods were verified to obtain reliable immobilization of protein receptors on the LPFG surface. We were able to detect 1 ng/mL norovirus VLPs in a 40-min assay in a label-free manner. Thanks to the application of an optical fiber as the sensor, there is a possibility to increase the user’s safety by separating the measurement point from the signal processing setup. Moreover, our sensor is small and light, and the proposed assay is straightforward. The designed LPFG-based biosensor could be applied in both fast norovirus detection and in vaccine testing.

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“…Next work utilizing the adhesin gp37 as a bioreceptor was reported by Piestrzynska et al [51]. Here, a label-free biosensing application of LPGs optimized in RI sensitivity by deposition of thin tantalum oxide (TaO x ) overlays was discussed.…”

Section: Adhesins-receptor Binding Proteinsmentioning

confidence: 99%

Long-Period Gratings and Microcavity In-Line Mach Zehnder Interferometers as Highly Sensitive Optical Fiber Platforms for Bacteria Sensing

Eftimov

Janik

Koba

et al. 2020

Sensors

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Selected optical fiber sensors offer extraordinary sensitivity to changes in external refractive (RI), which make them promising for label-free biosensing. In this work the most sensitive ones, namely long-period gratings working at (DTP-LPG) and micro-cavity in-line Mach-Zehnder interferometers (µIMZI) are discussed for application in bacteria sensing. We describe their working principles and RI sensitivity when operating in water environments, which is as high as 20,000 nm/RIU (Refractive index unit) for DTP-LPGs and 27,000 nm/RIU for µIMZIs. Special attention is paid to the methods to enhance the sensitivity by etching and nano-coatings. While the DTP-LPGs offer a greater interaction length and sensitivity to changes taking place at their surface, the µIMZIs are best suited for investigations of sub-nanoliter and picoliter volumes. The capabilities of both the platforms for bacteria sensing are presented and compared for strains of Escherichia coli, lipopolysaccharide E. coli, outer membrane proteins of E. coli, and Staphylococcus aureus. While DTP-LPGs have been more explored for bacteria detection in 102–106 Colony Forming Unit (CFU)/mL for S. aureus and 103–109 CFU/mL for E. coli, the µIMZIs reached 102–108 CFU/mL for E. coli and have a potential for becoming picoliter bacteria sensors.

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Ultrasensitive tantalum oxide nano-coated long-period gratings for detection of various biological targets

Cited by 59 publications

References 39 publications

Employing Higher Order Cladding Modes of Fiber Bragg Grating for Analysis of Refractive Index Change in Volume and at the Surface

Employing Higher Order Cladding Modes of Fiber Bragg Grating for Analysis of Refractive Index Change in Volume and at the Surface

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Long-Period Gratings and Microcavity In-Line Mach Zehnder Interferometers as Highly Sensitive Optical Fiber Platforms for Bacteria Sensing

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