We report a solid-state passively Q-switched Nd:YVO4 laser adopting rhenium diselenide (ReSe2) as saturable absorber (SA) materials. ReSe2 belongs to a type of transition metal dichalcogenides (TMDs) materials and it has the weak-layered dependent feature beneficial for the preparation of few-layer materials. The few-layer ReSe2 was prepared by ultrasonic exfoliation method. Using a power-dependent transmission experiment, its modulation depth and saturation intensity were measured to be 1.89% and 6.37 MW/cm2. Pumped by diode laser and based on few-layer ReSe2 SA, the Q-switched Nd:YVO4 laser obtained the shortest Q-switched pulse width of 682 ns with the highest repetition rate of 84.16 kHz. The maximum average output power was 125 mW with the slope efficiency of 17.27%. Our experiment, to the best of our knowledge, is the first demonstration that used ReSe2 as SA materials in an all-solid-state laser. The results show that the few-layer ReSe2 owns the nonlinear saturable absorption properties and it has the capacity to act as SA in an all-solid-state laser.