2014
DOI: 10.1016/j.biomaterials.2014.02.047
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Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds

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Cited by 169 publications
(151 citation statements)
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“…Furthermore, the amyloid hydrogels effected earlier onset and completion of autolytic debridement compared to the control, used as a standard-of-care. 166 The ultrashort aliphatic amyloid peptides were further explored for localized injectable anticancer therapy. The peptides were functionalized with platinum anti-cancer drugs and oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy in a mouse model.…”
Section: -151mentioning
confidence: 99%
“…Furthermore, the amyloid hydrogels effected earlier onset and completion of autolytic debridement compared to the control, used as a standard-of-care. 166 The ultrashort aliphatic amyloid peptides were further explored for localized injectable anticancer therapy. The peptides were functionalized with platinum anti-cancer drugs and oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy in a mouse model.…”
Section: -151mentioning
confidence: 99%
“…Drugs-eluting nanofibers provide a sustained release of antibiotics, and analgesics and growth factors/peptides enhance the healing of burn wounds [154][155][156]. Recent studies have incorporated proteins, particularly enzymes and growth factors, into treating various medical conditions (Figure 4).…”
Section: Multibiofunctional Nanofibersmentioning
confidence: 98%
“…The use of synthetic peptide hydrogels may minimize the risk of biological contamination. Previous studies examined synthetic self-assembling peptide-based gels [5,[6][7][8][9] and their applications, such as 3D cell culture scaffolds, [10][11][12][13] hemostats, [14,15] lubricants for osteoarthritis, [16] regenerative medicine, [17] wound healing, [18] and drug delivery systems. [19,20] The efficacy of these self-assembled materials may be affected by various factors, including pH, temperature, and the concentrations of salt and peptides.…”
Section: Introductionmentioning
confidence: 99%