Ultrasmall and customizable multichannel electrodes for extracellular recordings

Piironen, Arto; Weckström, Matti; Vähäsöyrinki, Mikko

doi:10.1152/jn.00790.2010

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Finally, it is controlled with a standard computer and software that provides flexible stimulus generation and control possibilities. These technical features coupled with demonstrable success in both behavioural and electrophysiological experiments (see also 37 ) allow us to conclude that the system is suitable for presenting animals with the behaviourally relevant and naturalistic stimuli. Further details of the design, including manufacturing instructions, are available from authors upon request to enable system replication.…”

Section: Discussionmentioning

confidence: 92%

A fast and flexible panoramic virtual reality system for behavioural and electrophysiological experiments

Takalo

Piironen

Honkanen

et al. 2012

Sci Rep

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Ideally, neuronal functions would be studied by performing experiments with unconstrained animals whilst they behave in their natural environment. Although this is not feasible currently for most animal models, one can mimic the natural environment in the laboratory by using a virtual reality (VR) environment. Here we present a novel VR system based upon a spherical projection of computer generated images using a modified commercial data projector with an add-on fish-eye lens. This system provides equidistant visual stimulation with extensive coverage of the visual field, high spatio-temporal resolution and flexible stimulus generation using a standard computer. It also includes a track-ball system for closed-loop behavioural experiments with walking animals. We present a detailed description of the system and characterize it thoroughly. Finally, we demonstrate the VR system’s performance whilst operating in closed-loop conditions by showing the movement trajectories of the cockroaches during exploratory behaviour in a VR forest.

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Section: Discussionmentioning

confidence: 92%

A fast and flexible panoramic virtual reality system for behavioural and electrophysiological experiments

Takalo

Piironen

Honkanen

et al. 2012

Sci Rep

Self Cite

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“…Moreover, the functionality of microcapillary could be increased by pulling a multibarrel capillary to provide independent control of different fluid flows for microfluidic applications, such as the creation of droplets with complex content . Multifunctional micropipettes can also be accomplished by jointly pulling glass capillaries with other materials such as carbon fibers, or metal nanoparticles . However, the electrical properties, such as the electrical conductivity of the pulled wires, are not easy to control, and the postprocessing of the composite pipettes before they can be used could be complicated …”

Section: Introductionmentioning

confidence: 99%

Liquid Metal‐Based Multifunctional Micropipette for 4D Single Cell Manipulation

et al. 2018

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A novel manufacturing approach to fabricate liquid metal‐based, multifunctional microcapillary pipettes able to provide electrodes with high electrical conductivity for high‐frequency electrical stimulation and measurement is proposed. 4D single cell manipulation is realized by applying multifrequency, multiamplitude, and multiphase electrical signals to the microelectrodes near the pipette tip to create 3D dielectrophoretic trap and 1D electrorotation, simultaneously. Functions such as single cell trapping, patterning, transfer, and rotation are accomplished. Cell viability and multiday proliferation characterization has confirmed the biocompatibility of this approach. This is a simple, low‐cost, and fast fabrication process that requires no cleanroom and photolithography step to manufacture 3D microelectrodes and microchannels for easy access to a wide user base for broad applications.

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“…These devices are built placing the electrode in the inner core surrounded by the other capillaries. Alternately, McCarthy et al employed titanium-based multi-channel electrodes for recording neural signals [18], whereas Piironen et al developed carbon microtetrodes for neuroanalytical applications [19]. The neurons vary in size and morphology, thus this electrode with multiple recording sites was a powerful tool for the detection of extracellular voltage signals.…”

Section: Introductionmentioning

confidence: 99%

Improved potentiometric SECM imaging of galvanic corrosion reactions

et al. 2017

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The galvanic corrosion of Zn-Cu systems has been monitored in situ using scanning electrochemical microscopy in the potentiometric mode. Here, the initial studies performed using double-barrel microelectrodes for the simultaneous detection of local pH and Zn ion concentration changes in single lines scans, have been extended to the obtention of 2-D maps of Cu 2+ and Zn 2+ ions. The construction and calibration of a novel Cu 2+ ion selective microelectrode is reported. New scanning algorithms and data evaluation tools have been explored for faster acquisition rates than those limited by the time constants associated to potentiometric response.

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Ultrasmall and customizable multichannel electrodes for extracellular recordings

Cited by 8 publications

References 31 publications

A fast and flexible panoramic virtual reality system for behavioural and electrophysiological experiments

A fast and flexible panoramic virtual reality system for behavioural and electrophysiological experiments

Liquid Metal‐Based Multifunctional Micropipette for 4D Single Cell Manipulation

Improved potentiometric SECM imaging of galvanic corrosion reactions

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