Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase

Hao, Ran; Zhang, Gangwan; Zhang, Jiahe; Zeng, Leyong

doi:10.1016/j.jcis.2023.10.037

Cited by 13 publications

(4 citation statements)

References 59 publications

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“…These findings were in agreement with the reported literature based on Au/Pt nanoparticles for cancer therapy . The UV–vis spectral scanning before and after loading Pt nanoparticles indicated a slight rise in temperature after loading Pt nanoparticles, presenting their photothermal performance . In another instance, an increase in the UV absorption intensity of Pt nanoparticles at 808 nm was observed with the rise in their concentration .…”

supporting

confidence: 92%

“…50 The UV−vis spectral scanning before and after loading Pt nanoparticles indicated a slight rise in temperature after loading Pt nanoparticles, presenting their photothermal performance. 51 In another instance, an increase in the UV absorption intensity of Pt nanoparticles at 808 nm was observed with the rise in their concentration. 52 Therefore, these findings suggested that Ptmodified MoSe 2 -PEG constructs would synergistically improve the photothermal effect of the designed photosensitizer.…”

mentioning

confidence: 91%

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2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

Meng,

Zhao,

Xia

et al. 2024

ACS Materials Lett.

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The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. The enormous potential of intelligent materials that can act as drugs themselves results in the development of smart drugless or drug-like architectures, offering synergistic therapeutic effects. In this study, we demonstrate the generation of transition metalbased dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics for synergistic trimodal therapies against breast carcinoma. Initially, the progressive transformation of two-dimensional (2D) molybdenum selenide (MoSe 2 )-based nanosheets into nanoflower-like architectures by the thermal injection method is observed with time. Further, these flowers are subsequently decorated with an optimal amount of platinum (Pt) nanoparticles for nanocatalytic efficacy and surface-modified with polyethylene glycol (PEG) for improved biocompatibility, shortly denoted as Pt-MoSe 2 -PEG for light-assisted photothermal (PTT) and photodynamic (PDT), as well as light-augmented chemodynamic (CDT) modalities. A series of physicochemical characterizations and performance validations successfully demonstrated the generation of tumor (pH/GSH)-responsive degradable nanoflower-like structures, substantially improving their ability of reactive oxygen species generation, MoSe 2 -based PTT/PDT capability, and light-augmented CDT efficacy of the Pt nanoenzymes. Finally, in vitro and in vivo investigations in the 4T1 cell line and its xenograft tumor model in BALB/C mice, respectively, validated the synergistic trimodal therapies of Pt-MoSe 2 -PEG toward ablating breast carcinoma.

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supporting

confidence: 92%

mentioning

confidence: 91%

2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

Meng,

Zhao,

Xia

et al. 2024

ACS Materials Lett.

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“…In addition, AuNPs have superior photothermal conversion capacity to develop a PTT effect, which could be incorporated with photodynamic therapy and CDT for tumor therapy. 30…”

Section: Classification Of H2o2-supplying Materialsmentioning

confidence: 99%

“…26 The carboxyl group can be oxidised by H 2 O 2 to form a peroxycarboxylic group, which in turn is catalyzed by metal ions to form 1 O 2 . 27 In addition, H 2 O 2 could be catalyzed to generate oxygen under the action of catalysts such as MnO 2 , 28,29 hydrogen peroxidase catalase, 30,31 and iridium oxide. 32 Then the supply of oxygen could adjust the type and differentiation of immune cells and further reconstruct the tumor environment.…”

Section: Introductionmentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

Wu,

Wang,

et al. 2024

Adv Healthcare Materials

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Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers in generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF3@BiOI is synthesized via a co‐precipitation method, followed by in‐situ reduction to decorate it with Pt nanoparticles, resulting in BiF3@BiOI@Pt‐PVP (BBP) nanocomposite for enhancing SDT efficacy. The formation of the BiF3@BiOI heterojunction enhances charge separation ability. The decoration of Pt nanoparticles narrows the bandgap and alters the band positions and Fermi level of BBP, which can effectively mitigate the rapid recombination of electron‐hole pairs and facilitate a cascade reaction of ROS, thereby improving ROS generation efficiency with ultrasound excitation. Additionally, bismuth ions in BBP and the generated holes consume glutathione, exacerbating cellular oxidative damage, and triggering PANoptosis and ferroptosis. Furthermore, Pt nanoparticles demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide to oxygen. These functions are helpful against tumors for alleviating hypoxic conditions, reshaping the microenvironment, modulating immune cell infiltration capacity, and enhancing the efficacy of immunotherapy. The dual strategy of forming heterojunctions and sensitization with noble metals effectively enhances the efficacy of sono‐catalytic therapy‐induced immune activation in tumor treatment.

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Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase

Cited by 13 publications

References 59 publications

2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

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Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase

Cited by 13 publications

References 59 publications

2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Bi‐Pt Heterojunction Cascade Reaction Platform for Sono‐Immunotherapy of Tumors via PANoptosis and Ferroptosis

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Product

Resources

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Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications