Ultrasmall Chitosan–Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice

Song, Xiaojie; Wu, Hao; Shen, Li; Wang, Yanfang; Ma, Xiaojun; Tan, Mingqian

doi:10.1021/acs.biomac.5b00511

Cited by 45 publications

(36 citation statements)

References 38 publications

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“…Additionally, Cs/Gel MPs also displayed intensity change around 1540 cm ‐1 compared with Cs/Gel mixture. The intensity of representative absorption peak around 1540 cm −1 decreased when the amount of genipin increased among Cs/Gel MPs, which might result from the reaction between NH 2 and genipin, thus decreasing the intensity of NH in plane bending vibration …”

Section: Resultsmentioning

confidence: 99%

Genipin crosslinked microspheres as an effective hemostatic agent

Xiao

et al. 2018

Polymers for Advanced Techs

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Efficient hemorrhage control is of extreme importance to decrease mortality rates arising from traumatic bleeding. However, traditional hemostatic agents are limited to unsatisfied biocompatibility, inconvenient usage, and high cost. To this end, we have devised a novel hemostatic microsphere from chitosan and gelatin by using appropriate amount of genipin as a crosslinker. The performance of these Cs/GelMPs was evaluated with experiments in vitro and in vivo. Results in vitro showed that the best hemostatic efficacy was achieved by Cs/Gel-0.75 MPs (the mass fraction of genipin in Cs/Gel mixture is 8.6 × 10 −6 ). Skin laceration model indicated that the hemostatic time of Cs/Gel-0.75 MPs was within 12 seconds, which has been significantly shortened in comparison with commercial available products. Moreover, cytocompatibility results displayed that Cs/Gel-0.75 MPs caused no obvious cytotoxicity even at the high concentration of 40 μg/ml. Cs/Gel-0.75 MPs also possess satisfactory fluid absorption ratio and low hemolysis. Therefore, these Cs/Gel-0.75 MPs are promising candidates for further surgical wound hemostatic agent.

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Section: Resultsmentioning

confidence: 99%

Genipin crosslinked microspheres as an effective hemostatic agent

Xiao

et al. 2018

Polymers for Advanced Techs

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“…An ideal cancer PTT should kill the treated tumors, induce a systemic antitumor immunity, control metastatic tumors, and promote tumor resistance [ 130 ]. Indocyanine green (ICG) is a NIR dye that has been approved by the United States Federal Drug Administration (FDA) for clinical imaging agents due to its advantageous photochemical, photobiological, and pharmacokinetic properties [ 76 , 129 ]. ICG absorbs at approximately 780 nm and emits around 800 nm, making it highly suitable for bio-imaging applications with high signal-to-background ratio [ 76 ].…”

Section: Chitosan Polymer For Photonic Applicationsmentioning

confidence: 99%

“…Indocyanine green (ICG) is a NIR dye that has been approved by the United States Federal Drug Administration (FDA) for clinical imaging agents due to its advantageous photochemical, photobiological, and pharmacokinetic properties [ 76 , 129 ]. ICG absorbs at approximately 780 nm and emits around 800 nm, making it highly suitable for bio-imaging applications with high signal-to-background ratio [ 76 ]. Moreover, it can convert the absorbed light energy to produce heat for PTT treatment [ 76 ].…”

Section: Chitosan Polymer For Photonic Applicationsmentioning

confidence: 99%

“…ICG absorbs at approximately 780 nm and emits around 800 nm, making it highly suitable for bio-imaging applications with high signal-to-background ratio [ 76 ]. Moreover, it can convert the absorbed light energy to produce heat for PTT treatment [ 76 ]. However, the use of ICG for imaging and PTT is limited, because ICG is photo-degraded in aqueous solution [ 76 ] and unstable at high temperature, resulting in loss of absorption and fluorescence.…”

Section: Chitosan Polymer For Photonic Applicationsmentioning

confidence: 99%

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Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

Marpu

Benton

2018

IJMS

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Chitosan (CS) is a natural polymer derived from chitin that has found its usage both in research and commercial applications due to its unique solubility and chemical and biological attributes. The biocompatibility and biodegradability of CS have helped researchers identify its utility in the delivery of therapeutic agents, tissue engineering, wound healing, and more. Industrial applications include cosmetic and personal care products, wastewater treatment, and corrosion protection, to name a few. Many researchers have published numerous reviews outlining the physical and chemical properties of CS, as well as its use for many of the above-mentioned applications. Recently, the cationic polyelectrolyte nature of CS was found to be advantageous for stabilizing fascinating photonic materials including plasmonic nanoparticles (e.g., gold and silver), semiconductor nanoparticles (e.g., zinc oxide, cadmium sulfide), fluorescent organic dyes (e.g., fluorescein isothiocyanate (FITC)), luminescent transitional and lanthanide complexes (e.g., Au(I) and Ru(II), and Eu(III)). These photonic systems have been extensively investigated for their usage in antimicrobial, wound healing, diagnostics, sensing, and imaging applications. Highlighted in this review are the different works involving some of the above-mentioned molecular-nano systems that are prepared or stabilized using the CS polymer. The advantages and the role of the CS for synthesizing and stabilizing the above-mentioned optically active materials have been illustrated.

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“…The biochemical significance of genipin emerges in fact from a number of research projects in the areas of the therapies of vascular diseases, diabetes, hepatic dysfunctions, as well as biofabrication, dentistry, ophthalmology, wound healing and regeneration of nerve, tendon and other tissues, just to mention a few [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introduction and Scopementioning

confidence: 99%

Genipin-Crosslinked Chitosan Gels and Scaffolds for Tissue Engineering and Regeneration of Cartilage and Bone

et al. 2015

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The present review article intends to direct attention to the technological advances made since 2009 in the area of genipin-crosslinked chitosan (GEN-chitosan) hydrogels. After a concise introduction on the well recognized characteristics of medical grade chitosan and food grade genipin, the properties of GEN-chitosan obtained with a safe, spontaneous and irreversible chemical reaction, and the quality assessment of the gels are reviewed. The antibacterial activity of GEN-chitosan has been well assessed in the treatment of gastric infections supported by Helicobacter pylori. Therapies based on chitosan alginate crosslinked with genipin include stem cell transplantation, and development of contraction free biomaterials suitable for cartilage engineering. Collagen, gelatin and other proteins have been associated to said hydrogels in view of the regeneration of the cartilage. Viability and proliferation of fibroblasts were impressively enhanced upon addition of poly-l-lysine. The modulation of the osteocytes has been achieved in various ways by applying advanced technologies such as 3D-plotting and electrospinning of biomimetic scaffolds, with optional addition of nano hydroxyapatite to the formulations. A wealth of biotechnological advances and know-how has permitted reaching outstanding results in crucial areas such as cranio-facial surgery, orthopedics and dentistry. It is mandatory to use scaffolds fully characterized in terms of porosity, pore size, swelling, wettability, compressive strength, and degree of acetylation, if the osteogenic differentiation of human mesenchymal stem cells is sought: in fact, the novel characteristics imparted by GEN-chitosan must be simultaneously of physico-chemical and cytological nature. Owing to their high standard, the scientific publications dated 2010–2015 have met the expectations of an interdisciplinary audience.

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Ultrasmall Chitosan–Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice

Cited by 45 publications

References 38 publications

Genipin crosslinked microspheres as an effective hemostatic agent

Genipin crosslinked microspheres as an effective hemostatic agent

Shining Light on Chitosan: A Review on the Usage of Chitosan for Photonics and Nanomaterials Research

Genipin-Crosslinked Chitosan Gels and Scaffolds for Tissue Engineering and Regeneration of Cartilage and Bone

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