Ultrasmall iron oxide nanoparticles with MRgFUS for enhanced magnetic resonance imaging of orthotopic glioblastoma

Chen, Jingwen; Yang, Rui; Yu, Hongwei; Wu, Hao; Wu, Nan; Wang, Suhe; Yin, Xiaorui; Shi, Xiangyang; Wang, Han

doi:10.1039/d3tb02966b

J. Mater. Chem. B

2024

DOI: 10.1039/d3tb02966b

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Ultrasmall iron oxide nanoparticles with MRgFUS for enhanced magnetic resonance imaging of orthotopic glioblastoma

Jingwen Chen,

Rui Yang,

Hongwei Yu

et al.

Abstract: We report a zwitterionic USIO-based platform for tumor T1WI not only in a subcutaneous tumor, but also in an orthotopic GBM with MRgFUS-mediated BBB opening. The formed USIO NPs-1,3-PS may improve the precision imaging and therapeutic efficacy of GBM.

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Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs)

Salehirozveh,

Dehghani,

Mijakovic

2024

JFB

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Iron oxide nanoparticles (IONPs) have garnered significant attention in biomedical applications due to their unique magnetic properties, biocompatibility, and versatility. This review comprehensively examines the synthesis methods, surface functionalization techniques, and diverse biomedical applications of IONPs. Various chemical and physical synthesis techniques, including coprecipitation, sol–gel processes, thermal decomposition, hydrothermal synthesis, and sonochemical routes, are discussed in detail, highlighting their advantages and limitations. Surface functionalization strategies, such as ligand exchange, encapsulation, and silanization, are explored to enhance the biocompatibility and functionality of IONPs. Special emphasis is placed on the role of IONPs in biosensing technologies, where their magnetic and optical properties enable significant advancements, including in surface-enhanced Raman scattering (SERS)-based biosensors, fluorescence biosensors, and field-effect transistor (FET) biosensors. The review explores how IONPs enhance sensitivity and selectivity in detecting biomolecules, demonstrating their potential for point-of-care diagnostics. Additionally, biomedical applications such as magnetic resonance imaging (MRI), targeted drug delivery, tissue engineering, and stem cell tracking are discussed. The challenges and future perspectives in the clinical translation of IONPs are also addressed, emphasizing the need for further research to optimize their properties and ensure safety and efficacy in medical applications. This review aims to provide a comprehensive understanding of the current state and future potential of IONPs in both biosensing and broader biomedical fields.

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Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs)

Salehirozveh,

Dehghani,

Mijakovic

2024

JFB

View full text Add to dashboard Cite

show abstract

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Ultrasmall iron oxide nanoparticles with MRgFUS for enhanced magnetic resonance imaging of orthotopic glioblastoma

Abstract: We report a zwitterionic USIO-based platform for tumor T1WI not only in a subcutaneous tumor, but also in an orthotopic GBM with MRgFUS-mediated BBB opening. The formed USIO NPs-1,3-PS may improve the precision imaging and therapeutic efficacy of GBM.

Cited by 1 publication

References 55 publications

Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs)

Synthesis, Functionalization, and Biomedical Applications of Iron Oxide Nanoparticles (IONPs)

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