Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

Robinson, Joshua T.; Tabakman, Scott M.; Liang, Yongye; Wang, Hailiang; Casalongue, Hernan Sanchez; Vinh, Daniel; Dai, Hongjie

doi:10.1021/ja2010175

Cited by 1,947 publications

(1,391 citation statements)

References 35 publications

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“…As shown in Figure 1g, the BP nanosheets exhibit a typical broad absorption band spanning the ultraviolet and NIR regions similar to other 2D layered materials 53, 54. The extinction coefficient of the BP nanosheets is 31.4 Lg −1 cm −1 according to Beer's law,55 which is larger than those of most reported photothermal nanomaterials such as Au nanorods, GO nanosheets, WS 2 nanosheets, and BP quantum dots 56, 57, 58, 59…”

Section: Resultsmentioning

confidence: 78%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

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Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

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Section: Resultsmentioning

confidence: 78%

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

et al. 2018

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“…Upon exposure to IR irradiation, light is absorbed by the RGOs within the PDMS matrix and the optical energy is efficiently transduced into thermal energy through phonons in the sp 2 graphene sheets 22. Owing to the high thermal conductivity of graphene films and the intimate dispersion of RGOs within the PDMS matrix, heat is percolated through the matrix.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, graphene, which also possesses a high photothermal conversion efficiency,22 inspired us with a feasible way to realize photomechanical actuators with excellent performance 23. Herein, we present a feasible and scalable method for the fabrication of light‐driven polymeric composites based on reduced graphene oxides (RGOs) and thermally expanding microspheres (TEMs) that takes advantage of these materials' highly intriguing photothermal properties and large volume expansivity, respectively.…”

Section: Introductionmentioning

confidence: 99%

Graphene‐Based Polymer Bilayers with Superior Light‐Driven Properties for Remote Construction of 3D Structures

et al. 2017

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3D structure assembly in advanced functional materials is important for many areas of technology. Here, a new strategy exploits IR light‐driven bilayer polymeric composites for autonomic origami assembly of 3D structures. The bilayer sheet comprises a passive layer of poly(dimethylsiloxane) (PDMS) and an active layer comprising reduced graphene oxides (RGOs), thermally expanding microspheres (TEMs), and PDMS. The corresponding fabrication method is versatile and simple. Owing to the large volume expansion of the TEMs, the two layers exhibit large differences in their coefficients of thermal expansion. The RGO‐TEM‐PDMS/PDMS bilayers can deflect toward the PDMS side upon IR irradiation via the cooperative effect of the photothermal effect of the RGOs and the expansion of the TEMs, and exhibit excellent light‐driven, a large bending deformation, and rapid responsive properties. The proposed RGO‐TEM‐PDMS/PDMS composites with excellent light‐driven bending properties are demonstrated as active hinges for building 3D geometries such as bidirectionally folded columns, boxes, pyramids, and cars. The folding angle (ranging from 0° to 180°) is well‐controlled by tuning the active hinge length. Furthermore, the folded 3D architectures can permanently preserve the deformed shape without energy supply. The presented approach has potential in biomedical devices, aerospace applications, microfluidic devices, and 4D printing.

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“…Especially, the ultrathin Ti 3 C 2 nanosheets exhibit an especially high extinction coefficient (ε) of 25.2 L g −1 cm −1 , which is remarkably higher than that of GO nanosheets (3.6 L g −1 cm −1 ),85 and also notably larger than that of traditional Au nanorods (13.9 L g −1 cm −1 ),86 indicating a favorable NIR laser‐absorption property of Ti 3 C 2 nanosheets (Figure 4b). The photothermal conversion efficiency (η) was calculated to be 30.6%, higher than that of Au nanorods (21%),87 and Cu 9 S 5 nanocrystals (25.7%) 88.…”

Section: Therapeutic Applications Of Mxenesmentioning

confidence: 96%

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

2018

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Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because of their unique planar structure and prominent physiochemical properties. Generally, ceramic‐based biomaterials, fabricated by high‐temperature solid‐phase reactions, are preferred as bone scaffolds in hard tissue engineering because of their controllable biocompatibility and satisfactory mechanical property, but their potential biomedical applications in disease theranostics are paid much less attention, mainly due to their lack of related material functionalities for possibly entering and circulating within the vascular system. The emerging 2D MXenes, a family of ultrathin atomic nanosheet materials derived from MAX phase ceramics, are currently booming as novel inorganic nanosystems for biologic and biomedical applications. The metallic conductivity, hydrophilic nature, and other unique physiochemical performances make it possible for the 2D MXenes to meet the strict requirements of biomedicine. This work introduces the very recent progress and novel paradigms of 2D MXenes for state‐of‐the‐art biomedical applications, focusing on the design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, and biosafety issues. It is highly expected that the elaborately engineered ultrathin MXenes nanosheets will become one of the most attractive biocompatible inorganic nanoplatforms for multiple and extensive biomedical applications to profit the clinical translation of nanomedicine.

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Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy

Cited by 1,947 publications

References 35 publications

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Black‐Phosphorus‐Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer

Graphene‐Based Polymer Bilayers with Superior Light‐Driven Properties for Remote Construction of 3D Structures

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

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