Ultrasmall superparamagnetic iron oxides enhanced MR imaging in rats with experimentally induced endometriosis

Hyaluronic Acid-Modified Magnetic Iron Oxide Nanoparticles for MR Imaging of Surgically Induced Endometriosis Model in Rats

“…The EUTs abutting the abdominal wall always appeared to have the tubular, cystic structure filled with clear fluid. Our findings were also in line with that reported in the literature [24], where about 4 weeks after establishing the animal model, the size of EUTs seemed to be the largest lesion volume and thereafter, it varied. Histologically, the EUTs in rats contain endometrial glands and stroma, which are likely the human endometriotic lesions.…”

“…They found that the contrast agents persisted longer in endometriotic tissues due to the extensive angiogenesis in induced lesions and thus achieving enhanced MR signal intensity on T 1 WI image. In another study, ultrasmall superparamagnetic iron oxides (USPIO)-enhanced T 2 WI was used to detect the EUT with a size larger than 3 cm [24]. Large-sized endometriosis might have high tissue concentrations of clumped USPIO particles, resulting in focal regions of hypointensity signal.…”

Diagnostic Value of ER, PR, FR and HER-2-Targeted Molecular Probes for Magnetic Resonance Imaging in Patients with Breast Cancer

“…The MRI of BT47 and SKBR3 breast cancer cells showed that Ab-HER-2-USPIO could effectively enhance the T1 weighted images in vivo, and hence may contribute to the early diagnosis of breast cancer. In addition, Ab-HER-2-USPIO was associated with favorable in vitro biocompatibility and low in vivo toxicity, making it a popular agent to achieve MRI enhancement during in vivo investigation of neuroinflammation [57,58]. Although previous data indicate that HER-2-targeted MRI molecular probes may be used in the clinical diagnosis of breast cancer and facilitate the development of promising strategies for breast cancer treatments [46,47], in our study, we further observed Ab-HER-2-USPIO can specifically bind to breast cancer cells BT47 and SKBR3, thus enhancing the quality of T1 weighted MRI images; also, we found that Ab-HER-2-USPIO not only possessed better in vitro biocompatibility, but also showed low in vivo toxicity, identifying its great potential in clinical applications.…”

Nanobiotechnology in reproduction – pros and cons. A review

“…For example, a theranostic approach uses nanostructures to treat ectopic pregnancy and trophoblastic diseases (Kaitu'u-Lino et al, 2013), endometriosis (Lee et al, 2012), as well as uterine fibroids .…”

“…Exposition of zebrafish larvae to AgNPs induces cardiac and eye deformities, yolk sac oedema, finfold and tail abnormalities, skeletal flexure, head oedema, cardiac malformation and often abnormal tail (Lee et al, 2012). The frequent adverse effects of AgNPs can be explained by the action of Ag + ions released in an aqueous environment (Powers et al, 2011).…”