2014
DOI: 10.1038/nmat4066
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Ultrasoft microgels displaying emergent platelet-like behaviours

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Cited by 189 publications
(241 citation statements)
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References 28 publications
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“…We find that for equivalent ϕ, the resultant colloidal network is identical compared with that obtained with ULC μgels (Fig. 2I), illustrating that the formation of percolated colloidal networks is not specific to the ULC μgels, but rather driven by fibrin polymerization in the absence of any known or observed specific fiber-μgel and μgel-μgel interactions (18). Furthermore, the observed μgel domain organization also enables the fibrin in the μgel-free regions to essentially remain free of distortions due to the particles, a fact that is expected to be favorable given the rigid character of the fibrin fibers.…”
Section: Resultsmentioning
confidence: 52%
See 1 more Smart Citation
“…We find that for equivalent ϕ, the resultant colloidal network is identical compared with that obtained with ULC μgels (Fig. 2I), illustrating that the formation of percolated colloidal networks is not specific to the ULC μgels, but rather driven by fibrin polymerization in the absence of any known or observed specific fiber-μgel and μgel-μgel interactions (18). Furthermore, the observed μgel domain organization also enables the fibrin in the μgel-free regions to essentially remain free of distortions due to the particles, a fact that is expected to be favorable given the rigid character of the fibrin fibers.…”
Section: Resultsmentioning
confidence: 52%
“…The long migration distances also suggest that the cells rather exploit the long-time viscous behavior of the μgel suspension. of 2 mol % N,N'-methylene(bisacrylamide) (BIS) (16)(17)(18)22). Purified μgels were labeled with AlexaFluor dyes and lyophilized for future use.…”
Section: Methodsmentioning
confidence: 99%
“…[36][37][38] Current research in the field of platelet-mimetic technologies utilizes a wide variety of strategies including both naturally derived platelet derivatives and synthetic platelet strategies. In subsequent sections, we review various strategies that encompass a large range of approaches to achieve various goals such as wound targeting, drug delivery, and immune system evasion through platelet membrane cloaking.…”
Section: Platelets In Coagulation and Hemostasismentioning
confidence: 99%
“…A study performed by Ravikumar et al 54,55 also involved particles surface-decorated with VWF and collagen-binding ligands, with the purpose of promoting binding to VWF under shear flow and binding to collagen independent of shear flow in order to imitate the dual-binding adhesion and aggregation capability of natural platelets. The platelet-like particles developed by Brown et al 38 use sdFvs, identified through phage display techniques, to obtain a high specificity for fibrin, allowing the particles to target fibrin clots, and therefore secondary hemostasis (Figure 3). These platelet-like particles were found to spread within the fibrin network, and induce collapse of the fibrin network, without binding fibrinogen present in the blood stream or in areas without injured vasculature.…”
Section: Artificial Plateletsmentioning
confidence: 99%
“…[3][4][5]. These microgels can be environmentally sensitive, and are called "Smart Gels" or "Intelligent Gels", having the ability to sense changes of pH, temperature, humidity, intensity of light, salt concentration, osmotic pressure, surfactants or co-solvents or an electrical or magnetic field [6].…”
Section: Introductionmentioning
confidence: 99%