Ultrasomics for Early Evaluation of the Tumor Response to MicroRNA‐122 in a Nude Mouse Hepatocellular Carcinoma Model

Guo, Huanling; Chen, Li‐da; Li, Wei; Liang, Jin-Yu; Zhang, Jian‐chao; Li, Xin; Xie, Xiaoyan; Lü, Ming-De; Kuang, Ming; Wang, Wei

doi:10.1002/jum.15071

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Furthermore, miRNA expression profiles differ between different stages of cancer and healthy tissues, and previous studies have used miRNAs as diagnostic markers, either alone or in combination with other known biomarkers ( 14 – 16 ). Preliminary studies examining miRNA expression also used tissues to determine the functional and diagnostic roles of miRNAs ( 13 , 17 , 18 ), which have been reported to regulate the development and progression of cancer ( 19 , 20 ). It has also been revealed that miRNAs (miRs) can promote or inhibit the EMT process in cancer types ( 21 – 23 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression

Wang

Wen

et al. 2020

Mol Med Rep

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Melanoma is a malignant skin cancer type associated with a high mortality rate, but its treatment is currently not ideal. Both microrna (mir)-214 and cell adhesion molecule 1 (cadM1) are differentially expressed in melanoma, but their role in this cancer type remains unknown. Therefore, the aim of the present study was to investigate the role of cadM1 and mir-214 in melanoma to identify novel targets for its treatment. The expression levels of cadM1 and mir-214 in cells were detected by reverse transcription-quantitative Pcr (rT-qPcr). Moreover, cell viability, migration and invasion were measured by MTT, wound healing and Transwell assays, respectively. in addition, the relative expression levels of epithelial-mesenchymal transition (eMT)-related proteins in cells were detected by rT-qPcr and western blotting. it was found that the expression of cadM1 was inhibited in melanoma cells, while mir-214 expression was increased during melanoma tumorigenesis. Furthermore, mir-214 mimics promoted the viability, migration and invasion of melanoma cells. it was also demonstrated that the downregulation of cadM1 reversed the inhibitory effect of the mir-214 inhibitor in melanoma. Moreover, overexpression of cadM1 inhibited the eMT process in melanoma, while the mir-214 inhibitor suppressed the eMT process. The results also indicated that mir-214 promoted the eMT process by downregulating cadM1, which may represent a novel mechanism for the progression of melanoma.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression

Wang

Wen

et al. 2020

Mol Med Rep

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Contrast-enhanced ultrasound–based ultrasomics score: a potential biomarker for predicting early recurrence of hepatocellular carcinoma after resection or ablation

Huang

Ruan

Xian

et al. 2021

The British Journal of Radiology

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Objectives: This study aimed to construct a prediction model based on contrast-enhanced ultrasound (CEUS) ultrasomics features and investigate its efficacy in predicting early recurrence (ER) of primary hepatocellular carcinoma (HCC) after resection or ablation. Methods: This study retrospectively included 215 patients with primary HCC, who were divided into a developmental cohort (n = 139) and a test cohort (n = 76). Four representative images—grayscale ultrasound, arterial phase, portal venous phase and delayed phase—were extracted from each CEUS video. Ultrasomics features were extracted from tumoral and peritumoral area inside the region of interest. Logistic regression was used to establish models, including a tumoral model, a peritumoral model and a combined model with additional clinical risk factors. The performance of the three models in predicting recurrence within 2 years was verified. Results: The combined model performed best in predicting recurrence within 2 years, with an area under the curve (AUC) of 0.845, while the tumoral model had an AUC of 0.810 and the peritumoral model one of 0.808. For prediction of recurrence-free survival, the 2-year cumulative recurrence rate was significant higher in the high-risk group (76.5%) than in the low-risk group (9.5%; p < 0.0001). Conclusion: These CEUS ultrasomics models, especially the combined model, had good efficacy in predicting early recurrence of HCC. The combined model has potential for individual survival assessment for HCC patients undergoing resection or ablation. Advances in knowledge: CEUS ultrasomics had high sensitivity, specificity and PPV in diagnosing early recurrence of HCC, and high efficacy in predicting early recurrence of HCC (AUC > 0.8). The combined model performed better than the tumoral ultrasomics model and peritumoral ultrasomics model in predicting recurrence within 2 years. Recurrence was more likely to occur in the high-risk group than in the low-risk group, with 2-year cumulative recurrence rates, respectively, 76.5% and 9.5% (p < 0.0001).

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Ultrasomics for Early Evaluation of the Tumor Response to MicroRNA‐122 in a Nude Mouse Hepatocellular Carcinoma Model

Cited by 2 publications

References 31 publications

MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression

MicroRNA‑214 promotes the EMT process in melanoma by downregulating CADM1 expression

Contrast-enhanced ultrasound–based ultrasomics score: a potential biomarker for predicting early recurrence of hepatocellular carcinoma after resection or ablation

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