Ultrasonic Approach in Clitoria ternatea (Butterfly Pea) Extraction in Water and Extract Sterilization by Ultrafiltration for Eye Drop Active Ingredient

Anthika, Bea; Kusumocahyo, Samuel P.; Sutanto, Hery

doi:10.1016/j.proche.2015.12.046

Cited by 21 publications

(16 citation statements)

References 6 publications

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“…(Shahid et al, 2009). Furthermore, a recent study reported that the ultrasound-assisted aqueous extract of C. ternatea leaves and petals inhibited the growth of Staphylococcus aureus (Anthika et al, 2015). C. ternatea petals extracted for 30 min using ultrasound yielded the highest anthocyanin content and also displayed the highest antibacterial activity (Anthika et al, 2015).…”

Section: Historical and Current Applicationsmentioning

confidence: 99%

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

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The perennial leguminous herb Clitoria ternatea (butterfly pea) has attracted significant interest based on its agricultural and medical applications, which range from use as a fodder and nitrogen fixing crop, to applications in food coloring and cosmetics, traditional medicine and as a source of an eco-friendly insecticide. In this article we provide a broad multidisciplinary review that includes descriptions of the physical appearance, distribution, taxonomy, habitat, growth and propagation, phytochemical composition and applications of this plant. Notable amongst its repertoire of chemical components are anthocyanins which give C. ternatea flowers their characteristic blue color, and cyclotides, ultra-stable macrocyclic peptides that are present in all tissues of this plant. The latter are potent insecticidal molecules and are implicated as the bioactive agents in a plant extract used commercially as an insecticide. We include a description of the genetic origin of these peptides, which interestingly involve the co-option of an ancestral albumin gene to produce the cyclotide precursor protein. The biosynthesis step in which the cyclic peptide backbone is formed involves an asparaginyl endopeptidase, of which in C. ternatea is known as butelase-1. This enzyme is highly efficient in peptide ligation and has been the focus of many recent studies on peptide ligation and cyclization for biotechnological applications. The article concludes with some suggestions for future studies on this plant, including the need to explore possible synergies between the various peptidic and non-peptidic phytochemicals.

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Section: Historical and Current Applicationsmentioning

confidence: 99%

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

et al. 2019

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“…The blue ternate leaf extract with the addition of 50% ethanol has the same effectiveness as the pure extract because the addition of ethanol makes it more insecticidal activity due to an increase in the high anthocyanin content. Besides, the high anthocyanin content makes for good antimicrobial activity as well (Shahid et al, 2009;Anthika et al, 2015;Ajesh & Sreejith, 2014).…”

Section: Discussionmentioning

confidence: 99%

Insecticidal Effects of Blue Ternate (Clitoria Ternatea) Leaf Extract Against Mosquito Wrigglers

Valdez¹,

Abusama²,

Lapuz³

et al. 2021

ASEAN J. Sci. Eng.

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The purpose of conducting this research is to determine the effectiveness of blue ternate (Clitoria Ternatea) leaf extracts for terminating mosquito wrigglers by making a mosquito larvae insecticide. To determine the effectiveness of the leaf extract to terminate mosquito wrigglers, a mortality test was conducted. The numbers of the dead mosquito wrigglers were checked every 5 min. The results showed that the blue ternate leaf is effective to eliminate mosquito wriggler and the amount of leaf extract in the ethanol brings different effectiveness. The present study showed that both ethanolic extract and pure leaf extract of Clitoria Ternatea are effective as insecticidal against mosquito wrigglers. The insecticidal effects of Clitoria Ternatea against mosquito wrigglers will contribute largely to the people, to help those people who cannot afford to buy insecticide and to lessen the number of people who encounter diseases caused by mosquitoes.

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“…The total anthocyanin content (TAC) was determined using a pH difference method (Anthika et al, 2015; Escher et al, 2020; Pasukamonset, Kwon, & Adisakwattana, 2016). The sample was diluted with 1 M hydrochloric acid solution (pH 1.0) and 1 M sodium hydroxide solution (pH 4.5) and equilibrated for 20 min.…”

Section: Methodsmentioning

confidence: 99%

“…Butterfly pea (scientific name: Clitoria ternatea ) is a plant species belonging to the Fabaceae family; it has a bright blue color and is rich in phenolic compounds, mainly flavonol glycosides, anthocyanins, and proanthocyanidins. The authors proposed that Clitoria ternatea could play a variety of roles: as an antioxidant (Escher et al, 2020; Verma, Itankar, & Arora, 2013), antibacterial agent (Anthika, Kusumocahyo, & Sutanto, 2015), in scavenging free radicals, and preventing cardiovascular diseases (Verma et al, 2013). Recent studies have demonstrated the health‐promoting effects of Clitoria ternatea petals, including antiasthma (Singh, Garabadu, Sharma, Shrivastava, & Mishra, 2018), antidiabetes (Verma et al, 2013), and anti‐inflammatory activities (Adhikary, Sultana, & Bishayi, 2018; Singh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Clitoria ternatea extract in liposomes by synergistic combination of probe‐type ultrasonication and high‐pressure processing

Chen

Chang

2020

Journal of Food Safety

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Clitoria ternatea petals are commonly used in health drinks and natural food colorants due to their antioxidant and antibacterial effects, as well as preventing cardiovascular diseases. In this study, the extract of Clitoria ternatea petals obtained under different temperature conditions was analyzed for their antioxidant components (polyphenols, flavonoids, anthocyanins) and their antioxidant capacity (DPPH free-radical scavenging rate). The effects of the homogenization mode, ratio of lecithin to cholesterol, extract concentration of Clitoria ternatea petals, and extraction temperature on the diameter and uniform of liposome were also investigated to protect their active biological activities. Furthermore, the objective of this study was to improve the homogeneous size distribution of liposomes by probe-type ultrasonication and highpressure processing (HPP) under the effect of pressure through hydrostatic pressure. The results showed that the extract of Clitoria ternatea petals for the best antioxidant effect was obtained at 50 C. According to the results of the Taguchi method, the optimal liposome particle size was the 1:0.15 ratio of lecithin to cholesterol, extract concentration was 0.7%, using the homogenization mode of the probe-type ultrasonication. As a result, HPP was first employed as a useful method for the preparation of liposome and the improvement of particle size and polydispersity index via the preprocessing of probe sonication and showed considerable promise for use in encapsulation in the dairy beverage, pharmaceutical, and cosmetic industries.

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Ultrasonic Approach in Clitoria ternatea (Butterfly Pea) Extraction in Water and Extract Sterilization by Ultrafiltration for Eye Drop Active Ingredient

Cited by 21 publications

References 6 publications

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Butterfly Pea (Clitoria ternatea), a Cyclotide-Bearing Plant With Applications in Agriculture and Medicine

Insecticidal Effects of Blue Ternate (Clitoria Ternatea) Leaf Extract Against Mosquito Wrigglers

Encapsulation of Clitoria ternatea extract in liposomes by synergistic combination of probe‐type ultrasonication and high‐pressure processing

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