Ultrasonic Characterization (Integrated Backscatter) of Myocardial Tissue in Patients with Autosomal Dominant Polycystic Kidney Disease

Jin, Xiucai; Shu, Rong; Mei, Changlin; Chen, Jiabin; Ye, Chaoyang; Chen, Xiaoyu

doi:10.1159/000276581

Cited by 3 publications

(5 citation statements)

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“…The results obtained from patients with dilated cardiomyopathy 39,41 and aortic stenosis 42 suggest, however, that ultrasonic tissue characterization may be a reliable indicator of the degree of myocardial fibrosis. We studied cardiac fibrosis in ADPKD patients with IBS, 8 and the echo protocol performed in our study was the same as that we used previously.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasonic characterization of the myocardium was performed using a special software package on the HP Son-os5500 after conventional echocardiography, as described previously. 8 Integrated backscatter values were measured from an operator-defined region of interest (ROI), and IBS images were calibrated in decibels within a range of 0 to 64 dB. Transmit power, log compression, and time-gain compensation settings were adjusted to the same values on examination of each subject.…”

Section: Ultrasonic Tissue Characterizationmentioning

confidence: 99%

“…Ultrasonic tissue characterization with integrated backscatter (IBS) offers a promising method for noninvasive assessment of myocardial fibrosis and contractile performance 5,6 . Integrated backscatter has been used to study myocardial changes in patients with hypertension, 7 autosomal dominant polycystic kidney disease (ADPKD), 8 and pheochromocytoma 9 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 Ultrasonic tissue characterization with integrated backscatter (IBS) offers a promising method for noninvasive assessment of myocardial fibrosis and contractile performance. 5,6 Integrated backscatter has been used to study myocardial changes in patients with hypertension, 7 Correspondence to: S. Rong autosomal dominant polycystic kidney disease (AD-PKD), 8 and pheochromocytoma. 9 Conventional hemodialysis (CHD) (4 hours per session and 3 sessions per week) is the most widely used modality of renal replacement therapy, but a treatment with an annual mortality rate of up to 25% 10 can hardly be considered an ideal one.…”

Section: Introductionmentioning

confidence: 99%

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Effects of thrice-weekly in-center nocturnal vs. conventional hemodialysis on integrated backscatter of myocardial tissue

Jin¹,

Shu

Mei

et al. 2011

Hemodialysis International

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Ultrasonic tissue characterization with integrated backscatter (IBS) offers a promising method for the noninvasive assessment of myocardial fibrosis and contractile performance. The aim of this study was to investigate the effect of thrice-weekly in-center nocturnal hemodialysis (INHD) and conventional hemodialysis (CHD) on myocardial fibrosis and left ventricular function in end-stage renal disease patients. Thirty-two INHD and 58 matched CHD patients were enrolled; baseline and 12-month measures of blood pressure (BP), serum calcium and phosphorus, echocardiographic left ventricular mass index (LVMI) and left ventricular function, the myocardial calibrated IBS (C-IBS), and systodiastolic cyclical variations in IBS (CV-IBS) were collected. The baseline characteristics were similar between groups, except that serum phosphorus and calcium × phosphorus were higher in the INHD group. At 12-month follow-up, there was a significant decrease in the mean C-IBS (-20.2 ± 3.7 to -28.1 ± 4.0 dB, P<0.01) and a significant increase in CV-IBS (5.0 ± 1.5 to 7.1 ± 1.6 dB, P<0.01) in INHD patients. Multivariate analysis showed that the mean C-IBS was positively related to SBP, DBP, LVMI, serum phosphorus, and left atrial volume index and inversely related to midwall fractional shortening, transmitral E/A ratio, and E(m) . The mean CV-IBS was positively correlated with left ventricular midwall fractional shortening, E/A ratio, E(m) and inversely correlated with SBP, DBP, LVMI, serum phosphorus, E/E(m) , and left atrial volume index. There was no significant change in the mean C-IBS, mean CV-IBS, and LVMI in the CHD group. Compared with CHD, INHD improves myocardial fibrosis and left ventricular function, and control of serum phosphorus is associated with the improvement of myocardial fibrosis. Improvement of myocardial fibrosis contributes to the reduction of left ventricle hypertrophy.

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Section: Discussionmentioning

confidence: 99%

Section: Ultrasonic Tissue Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of thrice-weekly in-center nocturnal vs. conventional hemodialysis on integrated backscatter of myocardial tissue

Jin¹,

Shu

Mei

et al. 2011

Hemodialysis International

Self Cite

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“…In any case, PC1 and PC2 are involved in several intracellular signaling pathways, which can influence cardiac function. PC-1 regulates mammalian target of rapamycin (mTOR) and PC-2 can influence B-cell lymphoma-2 (Bcl-2), leading to a down-regulation of mitophagy and apoptosis; both include pathways which can trigger hypertrophy in cardiac muscle [24][25][26][27][28][29][30]. Based on this hypothesis, PC-1 or PC-2 abnormalities in the heart could lead to an impairment in cardiac structure and function independently of kidney function or blood pressure.…”

Section: Left Ventricular Hypertrophy and Molecular Mechanismsmentioning

confidence: 99%

Assessment of Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease

et al. 2023

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Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease which leads to progressive kidney failure. About 5–10% of patients requiring renal replacement therapy are affected by ADPKD. Cardiovascular diseases are the main causes of morbidity and mortality in these patients with ADPKD; arterial hypertension (AH) is the first symptom with a very early onset. Anyway, some other cardiovascular abnormalities have been reported in ADPKD regardless of the presence of AH. With this background, we conducted a systematic review, collecting all randomized controlled trials (RCTs) and quasi-RCTs found on the main databases; we evaluated the evidence about different imaging techniques to grade the cardiovascular risk in a very early stage of disease. This review aims to describe all cardiovascular assessments in ADPKD patients to improve clinicians’ ability to discover cardiovascular involvement early, allowing appropriate therapies promptly.

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Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease

Shang

Wang²,

Chen³

et al. 2023

Front. Cell Dev. Biol.

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Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Although next-generation sequencing (NGS) technology can be used to sequence tens of thousands of DNA molecules simultaneously. It has poor capture efficiency for the six PKD1 pseudogenes and GC-rich regions. Multiplex ligation-dependent probe amplification (MLPA) technology can detect consecutive deletions of exons, but it is less sensitive for single-base mutations. However, pathogenic genes might not be detected in some patients, even when using the above methods. Improving the detection rate of pathogenic genes is an important technical problem hindering clinical diagnosis of ADPKD. Four pedigrees of ADPKD patients with mutation sites not identified by NGS were examined by other methods. First, MLPA was performed. Then, pedigrees in which MLPA did not identify pathogenic genes were subjected to multiplex polymerase chain reaction (MPCR) and targeted region sequencing. Finally, the detected mutation sites were verified by Sanger sequencing. The results showed that MLPA detected the following PKD1 exonic deletion mutations in three pedigrees: PKD1-18 nt–290 nt, PKD1-up-257 nt, PKD1-up-444 nt and PKD1-3 nt–141 nt. A new mutation site was identified through targeted region sequencing in one pedigree: PKD1 NM_001009944: c.151T > C at the protein level, described as p. Cys51Arg. In summary, we established a system of genetic detection and analytical methods, from NGS to MLPA to targeted region sequencing and finally to Sanger sequencing. We combined MPCR and targeted region sequencing for the first time in ADPKD diagnosis, which further improved diagnosis accuracy. Moreover, we identified one new missense mutation and four new deletion mutations.

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Ultrasonic Characterization (Integrated Backscatter) of Myocardial Tissue in Patients with Autosomal Dominant Polycystic Kidney Disease

Cited by 3 publications

References 46 publications

Effects of thrice-weekly in-center nocturnal vs. conventional hemodialysis on integrated backscatter of myocardial tissue

Effects of thrice-weekly in-center nocturnal vs. conventional hemodialysis on integrated backscatter of myocardial tissue

Assessment of Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease

Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease

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