I am pleased to present the FY 2000 Annual Report on Laboratory Directed Research and Development (LDRD) at the Pacific Northwest National Laboratory. From our LDRD program springs a renewed vitality of science and technology, a test bed for promising research, and most importantly, a strengthened ability to address complex problems of national importance.The LDRD program provides an opportunity for our staff to conduct experimental research on advanced scientific areas that have the potential for important new discoveries and innovative solutions to difficult technical problems. These projects span a broad range of topics-from subsurface microbes to atmospheric processes, and from nanoscale atom clusters to geologic oil reserves.Perhaps one of the most exciting LDRD projects described in this year's report is one in the life sciences where we have extended previous work in genomics into the new frontier area of proteomics. Using mass spectrometry to catalogue and characterize proteins on a large scale, we can now rapidly identify proteins that are made in response to a change in the cellular environment. Many of these proteins have never been described. This advance in fundamental biology could greatly improve our understanding of how cells respond to toxic insults and could lead to new techniques for bioremediation and environmental cleanup as well as early diagnosis and treatment of diseases.As we head into the next century, we will be relying on the LDRD program to form the foundation for a new generation of products and processes that will benefit the U.S. Department of Energy, the nation, and the taxpayers. For example, LDRD-funded research on fuel cells promises to yield important new advances in powering energy-efficient, low-polluting automobiles and trucks. The increasing importance of computer information and network security also is being addressed through LDRD research, where we are developing technologies that could prevent destructive intrusions on national energy, transportation, and communication centers.Keeping us at the cutting edge of science and technology, the LDRD program fosters an innovative work environment that helps us recruit and retain the best and brightest staff. Here, our scientists and engineers are encouraged to turn their discoveries into practical solutions.The LDRD program has proven essential to the outstanding record of achievement at Pacific Northwest National Laboratory, and we expect it to remain a cornerstone of our success in the 21 st century.