2007
DOI: 10.1016/j.ultrasmedbio.2006.07.037
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Ultrasonic Characterization of Whole Cells and Isolated Nuclei

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Cited by 106 publications
(91 citation statements)
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References 36 publications
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“…The previous studies include those investigations where apoptosis was induced in cells and normal tissues using a variety of modalities and were analyzed using ultrasound data (7)(8)(9)(10)(11)(12)(13)(14). It was shown that nuclear condensation by the induction of apoptotic death can result in increases in ultrasonic backscatter signal intensity, which is consistent with observations in this study.…”
Section: Discussionsupporting
confidence: 87%
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“…The previous studies include those investigations where apoptosis was induced in cells and normal tissues using a variety of modalities and were analyzed using ultrasound data (7)(8)(9)(10)(11)(12)(13)(14). It was shown that nuclear condensation by the induction of apoptotic death can result in increases in ultrasonic backscatter signal intensity, which is consistent with observations in this study.…”
Section: Discussionsupporting
confidence: 87%
“…Ultrasound radiofrequency data analysis was conducted using linear regression analysis of the normalized power spectrum (7)(8)(9)(10)(11)(12)(13)(14)(15)(17)(18)(19)(20). Ultrasound data was analyzed across all acquired planes through the scan volume which included identifiable tumor regions.…”
Section: Discussionmentioning
confidence: 99%
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“…6). These histologic observations and evidence from previous work (12,13,31,34,35) suggested that the main changes in the ultrasound backscatter after radiotherapy were related to changes in nuclear size and properties.…”
Section: Discussionsupporting
confidence: 65%
“…37 Currently, it is difficult to determine the cell structures responsible for this observation. However, other studies have indicated that cells undergoing apoptosis feature changes in the elastic and viscous moduli, 8,38 which may have an impact on the sound speed.…”
Section: Discussionmentioning
confidence: 99%