Ultrasonic/electrical dual stimulation response nanocomposite bioelectret for controlled precision drug release

Li, Junfei; Xie, Yu; Zou, Xiaoran; Li, Zhengze; Liu, Wenbo; Liu, Guodong; Ma, Mengjiao; Zheng, Yudong

doi:10.1016/j.mtbio.2023.100665

Cited by 3 publications

(6 citation statements)

References 60 publications

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“…Similarly, when the biomaterial is polarized, polarized biomaterial can store charges in the body for a long time. In some cases, the change of charge can be driven by stimuli such as ultrasound and external forces, which can achieve local electrical stimulation of cells and tissues noninvasively, thus affecting each other in the biological environment. , To understand how this polarization density biomaterial interacts in the biological environment, we introduce an external electret state to compensate the microenvironment electret state of damaged tissue, thus affecting cell behaviors such as cytoskeleton and subcellular organ structure, proliferation, differentiation, and immune regulation, inducing and activating the corresponding tissue state, realizing self-regulation, and promoting healing and repair. , …”

Section: Endogenous Electric Fields and Biological Mechanismsmentioning

confidence: 99%

“…In recent years, polymeric bioelectret materials have made certain research progress in the fields of tissue repair such as bone repair, nerve repair, enhanced drug permeation, and wound healing, due to their advantages of being lightweight and having high quasi-piezoelectric sensitivity and good flexibility. ,, However, polymer electret materials still face significant challenges in terms of their charge storage capacity and charge stability. In order to optimize and improve the performance and function of polymer electret materials, it is an effective way to improve the electron charge storage capacity by doping nanofillers into the polymer matrix .…”

Section: Bioelectret Materials and Their Classificationmentioning

confidence: 99%

“…Immunohistological studies showed that after the use of a negative electret 5-FU patch, collegan type I, collegan type III, TGF-β1, and HSP47 were significantly lower than that of 5-FU patches (Figure B). Li reported a drug-loaded composite polymer electret that uses carnauba wax nanoparticles as a dipole, which is flexible and nontoxic and can stimulate change of electret surface charge through stress changes and ultrasound and can regulate drug release by ultrasonic electrical double stimulation response (Figure C).…”

Section: Application Of Bioelectret Materials In Regulating Tissue Re...mentioning

confidence: 99%

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Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

Li,

Xie,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Biophysical and clinical medical studies have confirmed that biological tissue lesions and trauma are related to the damage of an intrinsic electret (i.e., endogenous electric field), such as wound healing, embryonic development, the occurrence of various diseases, immune regulation, tissue regeneration, and cancer metastasis. As exogenous electrical signals, such as conductivity, piezoelectricity, ferroelectricity, and pyroelectricity, bioelectroactives can regulate the endogenous electric field, thus controlling the function of cells and promoting the repair and regeneration of tissues. Materials, once polarized, can harness their inherent polarized static electric fields to generate an electric field through direct stimulation or indirect interactions facilitated by physical signals, such as friction, ultrasound, or mechanical stimulation. The interaction with the biological microenvironment allows for the regulation and compensation of polarized electric signals in damaged tissue microenvironments, leading to tissue regeneration and repair. The technique shows great promise for applications in the field of tissue regeneration. In this paper, the generation and change of the endogenous electric field and the regulation of exogenous electroactive substances are expounded, and the latest research progress of the electret and its biological effects in the field of tissue repair include bone repair, nerve repair, drug penetration promotion, wound healing, etc. Finally, the opportunities and challenges of electret materials in tissue repair were summarized. Exploring the research and development of new polarized materials and the mechanism of regulating endogenous electric field changes may provide new insights and innovative methods for tissue repair and disease treatment in biological applications.

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Section: Endogenous Electric Fields and Biological Mechanismsmentioning

confidence: 99%

Section: Bioelectret Materials and Their Classificationmentioning

confidence: 99%

Section: Application Of Bioelectret Materials In Regulating Tissue Re...mentioning

confidence: 99%

See 1 more Smart Citation

Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

Li,

Xie,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

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“…The mechanism is shown in Figure 7 D. Corresponding experiments including in vitro skin penetration assays and anti-inflammatory effects were performed, which showed that transdermal delivery of protein drugs in TMC NPs was considerably improved in the presence of electrets. In addition, Li et al successfully prepared a flexible, biocompatible drug-laden composite electret (nCW) using thermal polarization [ 152 ]. nCW’s nano effects increased the charge density and the “locked” dipole structure of the polymer matrix improved the charge stability.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Electrets: Recent Advance and Future Perspectives

Zhang

Zhao

Xie

et al. 2023

JFB

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Recently, electrical stimulation, as a non-pharmacological physical stimulus, has been widely exploited in biomedical and clinical applications due to its ability to significantly enhance cell proliferation and differentiation. As a kind of dielectric material with permanent polarization characteristics, electrets have demonstrated tremendous potential in this field owing to their merits of low cost, stable performance, and excellent biocompatibility. This review provides a comprehensive summary of the recent advances in electrets and their biomedical applications. We first provide a brief introduction to the development of electrets, as well as typical materials and fabrication methods. Subsequently, we systematically describe the recent advances of electrets in biomedical applications, including bone regeneration, wound healing, nerve regeneration, drug delivery, and wearable electronics. Finally, the present challenges and opportunities have also been discussed in this emerging field. This review is anticipated to provide state-of-the-art insights on the electrical stimulation-related applications of electrets.

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“…In addition to the stretchable ultrasonic patch, numerous novel types of transducers have also been proposed very recently, such as fiber based transducer, [ 305 ] electret, [ 306 ] and 3D printed transducer. [ 152 ] Miniaturized ultrasound transducers with microscale focusing features have been printed by Zheng's group.…”

Section: Applications Of Conformable Ultrasound Electronicsmentioning

confidence: 99%

An Emerging Era: Conformable Ultrasound Electronics

Zhang,

Du,

Kim

et al. 2023

Advanced Materials

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Conformable electronics are regarded as the next generation of personal healthcare monitoring and remote diagnosis devices. In recent years, piezoelectric based conformable ultrasound electronics (cUSE) have been intensively studied due to their unique capabilities, including no‐radiative monitoring, soft tissue imaging, deep signal decoding, wireless power transfer, portability, and compatibility. This review provides a comprehensive understanding of cUSE for use in biomedical and healthcare monitoring systems and a summary of their recent advancements. Following an introduction to the fundamentals of piezoelectrics and ultrasound transducers, the critical parameters for transducer design are discussed. Next, five types of cUSE with their advantages and limitations are highlighted, and the fabrication of cUSE using advanced technologies is discussed. In addition, the working function, acoustic performance, and accomplishments in various applications are thoroughly summarized. We note that application considerations must be given to the tradeoffs between material selection, manufacturing processes, acoustic performance, mechanical integrity, and the entire integrated system. Finally, we highlight current challenges and directions for the development of cUSE, and provide research flow as the roadmap for future research. In conclusion, these advances in the fields of piezoelectric materials, ultrasound transducers, and conformable electronics spark an emerging era of biomedicine and personal healthcare.This article is protected by copyright. All rights reserved

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Ultrasonic/electrical dual stimulation response nanocomposite bioelectret for controlled precision drug release

Cited by 3 publications

References 60 publications

Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

Biomedical Applications of Electrets: Recent Advance and Future Perspectives

An Emerging Era: Conformable Ultrasound Electronics

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